Clinical Trials

24 enrolled

Other solid neoplasm

Solid Tumors

NCT01517399 2019-02-12

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

28 enrolled

Neoplasms

NCT01699061 2019-02-12

Effect of Tivantinib on the QTC Interval in Cancer Subjects

38 enrolled

Other solid neoplasm

Solid Tumors

NCT02150733 2019-02-12

Pharmacokinetics of Tivantinib in Subjects With Advanced Solid Tumors and Hepatic Impairment

29 enrolled

Neoplasms

NCT01688973 2019-01-03

Tivantinib With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Locally Advanced Kidney Cancer That Cannot Be Removed by Surgery

55 enrolled 16 charts

Genitourinary

Carcinoma, Renal Cell

NCT01696955 2018-12-19

Cetuximab With or Without Tivantinib in Treating Patients With Head and Neck Cancer That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery

81 enrolled 14 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT01519414 2018-09-12

Tivantinib in Treating Patients With Metastatic Prostate Cancer

78 enrolled 12 charts

Genitourinary

Prostatic Neoplasms

NCT01395758 2018-04-03

Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

96 enrolled 19 charts

Carcinoma, Non-Small-Cell Lung

NCT01654965 2018-04-03

Tivantinib and Topotecan Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors

17 enrolled

Adult Solid Neoplasm

NCT01749384 2017-10-12

Tivantinib and Bevacizumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

12 enrolled

Solid Neoplasm

NCT02029157 2017-10-09

JET-HCC

Phase 3 Completed

386 enrolled

Liver Neoplasms

NCT01069757 2017-03-15

A Study of ARQ 197 in Combination With Erlotinib

16 enrolled

Carcinoma, Non-Small-Cell Lung

NCT01152645 2017-03-15

ARQ 197-004

31 enrolled

Stomach Neoplasms

NCT01251796 2017-03-15

A Study of ARQ 197 in Combination With Erlotinib

9 enrolled

GastrointestinalOther solid neoplasm

Carcinoma, Non-Small-Cell Lung

NCT01611857 2016-11-23

Phase I/II Trial of Tivantinib With FOLFOX for the Treatment of Advanced Solid Tumors and Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction or Stomach

Phase 1/2 Completed

49 enrolled 12 charts

Malignant Solid Tumour

NCT01575522 2016-03-21

Tivantinib in Treating Patients With Recurrent or Metastatic Breast Cancer

22 enrolled 10 charts

Breast

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT01625156 2015-10-20

Tivantinib and Temsirolimus in Treating Patients With Solid Tumors That is Metastatic or Cannot be Removed by Surgery

11 enrolled

Adult Solid Neoplasm

NCT01580735 2015-08-18

ARQ 197 Plus Erlotinib in Patient With Locally Advanced or Metastatic EGFR Mutation-positive Non-small-cell Lung Cancer

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT01725191 2015-07-02

Tivantinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors

36 enrolled

Childhood Solid Neoplasm

NCT00827177 2014-01-24

Dose Escalation Study of ARQ 197 in Combination With Sorafenib in Adult Patients With Advanced Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryThoracic

87 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Melanoma, Neoplasms

NCT00777309 2013-02-28

A Randomized Phase 2 Study of Erlotinib + ARQ 197 Versus Erlotinib + Placebo in Previously Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

167 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00988741 2013-02-28

Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapy

107 enrolled

Carcinoma

NCT00558207 2013-02-25

A Randomized Phase 2 Study of ARQ 197 Versus Gemcitabine in Treatment-Naïve Patients With Unresectable Locally Advanced or Metastatic Pancreatic Adenocarcinoma

43 enrolled

Pancreatic Neoplasms

NCT00557609 2013-02-08

Phase 2 Study in Patients With MiT Tumors

47 enrolled

GenitourinarySarcoma

Carcinoma, Renal Cell, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part

NCT00609921 2012-09-07

A Phase 1 Study of ARQ 197 in Patients With Solid Tumors

42 enrolled

Neoplasms

NCT00612209 2012-07-23

ARQ 197

51 enrolled

Neoplasms

NCT00612703 2012-07-23

A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors

32 enrolled

Neoplasms

NCT00874042 2012-07-23

Dose Escalation Study of ARQ 197 in Combination With Gemcitabine in Adult Patients With Advanced Solid Tumors

74 enrolled

Neoplasms

NCT00802555 2012-07-12

Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)

21 enrolled

Fibrosis, Carcinoma, Hepatocellular

NCT00302172 2009-08-26

ARQ 197 in Subjects With Metastatic Solid Tumors

78 enrolled