Clinical Trials Browser

Phase 1 × Completed × AZD 6244 × Clear all

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasms

Colorectal Neoplasms

Uveal Melanoma, Melanoma

Carcinoma, Non-Small-Cell Lung

Neoplasm Metastasis

Neurofibromatosis 1

Carcinoma, Non-Small-Cell Lung

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

Carcinoma, Non-Small-Cell Lung, Neoplasms

Advanced Cancer

Colonic Neoplasms, Colorectal Neoplasms

Biliary Tract Neoplasms, Breast Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms, Disease Progression

Locally Advanced or Metastatic Solid Tumors

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Neoplasms

Solid Tumors

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

Adult Solid Neoplasm

Solid Tumours

Solid Tumours

Renal Insufficiency

Solid Tumours

Solid Tumours

Healthy Volunteers Pharmacokinetic Study

Colonic Neoplasms, Rectal Neoplasms

Solid Tumours

Clinical Trials

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer

Intermittent Selumetinib for Uveal Melanoma

Study of Selumetinib in Patients With Previously Treated or Untreated Advanced/Metastatic NSCLC

MK-8353-014

Selumetinib Paediatric NF1 Japan Study

Selumetinib and Paclitaxel as Second-Line Treatment in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

MEKRT

A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)

A Study of ARRY-142886 in Patients With Advanced Cancer

AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer

A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours

A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010)

SELECT-3

Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer

A Study to Assess the Relative Bioavailability of Process Variants of Selumetinib in Healthy Male Volunteers

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Patients With Hepatic Impairment and Healthy Subjects

ABC-04

A Study to Assess the Absolute Bioavailability of Oral Selumetinib in Healthy Male Volunteers.

Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies

To Assess the Effects of Single Oral Dose of Selumetinib [AZD6244; ARRY-142886] [Hyd-Sulfate]), on QTc Interval in Healthy Male Volunteers

Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Renal Impaired Subjects and Healthy Subjects

To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

Study to Assess the Effect of Dosing AZD6244 HydSulfate in the Presence and Absence of Food in Patients With Advanced Solid Malignancies

To Assess the Effect of Food on the Pharmacokinetics of Selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in Healthy Male Volunteers

Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK

Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors

To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers