Clinical Trials Browser

OTHER × Interventional × Acetylcysteine × Clear all

NCT07117630 2026-05-19

An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy

Phase 2 Recruiting

Breast Neoplasms

NCT04520139 2026-04-29

Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

Phase 1/2 Not yet recruiting

Chemotherapy-Related Cognitive Impairment, Ovarian Neoplasms, Cognitive Dysfunction

NCT04481035 2026-04-21

NF1NAC

Phase 2 Completed

5 enrolled 10 charts

Neurofibromatosis 1

NCT05123365 2026-03-10

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

Phase 1/2 Recruiting

Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Primary Myelofibrosis

NCT05986318 2026-03-09

RESPIRE-ILD

Phase 2 Recruiting

Lung Neoplasms, Lung Diseases, Interstitial, Radiation Pneumonitis

NCT07391163 2026-02-10

Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer

Phase NA Completed

Gastrointestinal

Peripheral Nervous System Diseases, Colorectal Neoplasms

NCT07387666 2026-02-06

Imaging Acetadote Metabolism in Glioblastoma

Phase EARLY_PHASE1 Not yet recruiting

Glioblastoma

NCT07245095 2025-11-24

NACSIMET

Phase 2 Recruiting

Gastrointestinal

Stomach Neoplasms

NCT05081479 2025-11-04

A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma

Phase 1 Active not recruiting

Lymphoma

NCT07156786 2025-09-19

N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial

Phase 2/3 Not yet recruiting

Neoplasms, Acute Kidney Injury

NCT07082621 2025-07-24

N Acetylcystene in Treatment of Radiotherapy Induced Oral Mucositis in Oral Cancer Patients

Phase NA Completed

Stomatitis

NCT06836128 2025-07-09

PCOS

Phase 3 Recruiting

Polycystic Ovary Syndrome

NCT02569957 2025-05-04

Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Phase 2 Terminated

1 enrolled 5 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT06354712 2025-01-15

Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

Phase 2 Recruiting

Stomatitis, Ulcer

NCT06482034 2024-12-31

Effect of N-acetyl Cysteine and Zinc in Management of Head and Neck Cancer Radiotherapy Induced Oral Mucositis

Phase 2 Completed

Radiation-Induced Mucositis

NCT06115408 2024-12-16

Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma

Phase 2/3 Completed

Myofibroma

NCT06024031 2024-11-07

NAC for Promoting Hematopoietic Recovery in Patients With Acute Myeloid Leukemia After Chemotherapy

Phase 2 Active not recruiting

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT04481048 2024-10-09

DoDNAC

Phase 2 Active not recruiting

Neurofibromatosis 1

NCT04460521 2024-08-23

ACTS

Phase 4 Recruiting

Tomaculous neuropathy, Carpal Tunnel Syndrome, Disease, Hand Injuries, Neuroma, Median Neuropathy

NCT06122311 2024-07-05

Drug Nephrotoxicity Amelioration by N-acetylcysteine

Phase NA Completed

Drug-Induced Nephropathy

NCT06297369 2024-03-07

Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients

Phase 2 Unknown

Ototoxicity, Peripheral Nervous System Diseases

NCT06039280 2023-09-15

Comparison of Dexamethasone and N Acetylcysteine (NAC) Versus N Acetylcysteine (NAC) Alone in the Prevention of Post Embolization Syndrome in Patients With Hepatocellular Carcinoma Following Transarterial Chemoembolization.

Phase NA Unknown

Gastrointestinal

Carcinoma, Hepatocellular

NCT04291209 2023-09-06

Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.

Phase 1/2 Unknown

Deafness, Ear Diseases, Hearing Loss, Sensorineural, Hearing Loss

NCT02094625 2023-04-18

NAC to Prevent Cisplatin-induced Hearing Loss

Phase 1 Completed

GastrointestinalSarcoma

Liver Neoplasms, Osteosarcoma, Neuroectodermal Tumors, Primitive, Hearing Loss

NCT03982537 2022-12-19

Effect of N-Acetyl Cysteine (NAC) on the Oral Microbiome

Phase 2 Withdrawn

Head and Neck Neoplasms

NCT05611086 2022-11-09

N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia

Phase 4 Terminated

LymphoidOther hematologic neoplasm

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00637624 2022-08-25

NAC-PNP

Phase NA Terminated

Other solid neoplasmThoracic

Carcinoma, Non-Small-Cell Lung, Mesothelioma, Small Cell Lung Carcinoma

NCT04982146 2022-06-02

Intratumoral Bromelain + Acetylcysteine in Relapsed and Unresectable Pseudomyxoma Peritonei

Phase 1 Unknown

Pseudomyxoma Peritonei

NCT03492047 2020-02-27

N-acetyl Cysteine Effect in Peripheral Neuropathy in Cancer Patients

Phase 1/2 Completed

Peripheral Nervous System Diseases

NCT02123511 2019-04-30

Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

Phase 2 Completed

34 enrolled 16 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms, Mucositis

NCT01653171 2018-04-10

PRUE

Phase 4 Completed

Gastrointestinal

Stomach Neoplasms

NCT03400709 2018-01-17

Protective Role of N-acetylcisteine From Cisplatin-induced Ototoxicity in Patients With Head and Neck Cancer

Phase NA Completed

Ototoxicity

NCT02775734 2017-05-02

NAC

Phase 2/3 Completed

Polycystic Ovary Syndrome

NCT00238173 2017-04-21

Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors

Phase 1 Terminated

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Optic Nerve Glioma, Drug-Related Side Effects and Adverse Reactions

NCT01138137 2017-04-21

N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer

Phase 1 Withdrawn

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms

NCT02241876 2014-09-16

THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS

Phase 4 Unknown

Head and Neck Neoplasms

NCT02239107 2014-09-12

N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Phase 4 Completed

Insulin Resistance, Polycystic Ovary Syndrome

NCT01726465 2013-11-13

MENHIR

Phase 2 Terminated

Gastrointestinal

Carcinoma, Hepatocellular

NCT00512265 2013-08-28

Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer

Phase 4 Completed

Inflammation

NCT00003346 2013-06-25

Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma

Phase 2 Completed

Melanoma

NCT01394497 2013-02-18

Use of N-Acetylcysteine During Liver Procurement

Phase 2 Completed

Gastrointestinal

Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Liver Failure, Liver Failure, Acute, Primary Graft Dysfunction

NCT00196885 2008-06-20

Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training

Phase 2 Completed

GastrointestinalLymphoid

Carcinoma, Bronchogenic, Gastrointestinal Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Muscular Atrophy, Weight Loss