Clinical Trials

Leukemia, Lymphocytic, Chronic, B-Cell

NCT06705608 2024-11-26

MS; FTY720

Completed

4,000 enrolled

Dermatologic

Carcinoma, Basal Cell, Melanoma, Multiple Sclerosis, Skin Neoplasms, Multiple Sclerosis, Relapsing-Remitting

NCT03989466 2024-10-10

Itacitinib and Alemtuzumab in Treating Patients With T-Cell Prolymphocytic Leukemia

Phase 1 Completed

15 enrolled

Leukemia, Prolymphocytic, T-Cell

NCT02626715 2024-07-16

Reduced-Intensity Conditioning (RIC) and Myeloablative Conditioning (MAC) for HSCT in AML/MDS

MyeloidOther hematologic neoplasm

21 enrolled 24 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT02061800 2024-06-04

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Phase 1/2 Active not recruiting

14 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Neutropenia, Severe Congenital, Autosomal Recessive 3, Bone Marrow Failure Disorders, Shwachman-Diamond Syndrome, Primary Immunodeficiency Diseases, Acquired Immunodeficiency Syndrome, Anemia, Aplastic, Anemia, Sickle Cell, Hemoglobinopathies, Histiocytosis, Langerhans-Cell, Lymphoma, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Histiocytosis, Anemia, Diamond-Blackfan, Lymphohistiocytosis, Hemophagocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Macrophage Activation Syndrome

NCT03821610 2024-05-16

ALL-RIC

Phase 2 Active not recruiting

242 enrolled

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02385110 2024-01-17

Alemtuzumab or Tocilizumab in Combination With Etoposide and Dexamethasone for the Treatment of Adult Patients With Hemophagocytic Lymphohistiocytosis

MyeloidOther hematologic neoplasm

18 enrolled 10 charts

Leukemia, Lymphohistiocytosis, Hemophagocytic

NCT00199030 2023-03-20

Treatment of Relapsed T-cell Acute Lymphoblastic Leukemia or T-lymphoblastic Lymphoma With MabCampath

8 enrolled

Lymphoma, Recurrence, Neoplasm, Residual, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00951457 2022-03-03

Bendamustine Combined With Alemtuzumab in Pretreated Chronic Lymphocytic Leukemia (CLL)

20 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01186640 2022-01-05

Combined Immunochemotherapy in Patients With T-Prolymphocytic Leukemia (T-PLL)

16 enrolled

Leukemia, Prolymphocytic, T-Cell

NCT02497404 2021-09-22

Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR

MyeloidOther hematologic neoplasm

40 enrolled 21 charts

Leukemia, Erythroblastic, Acute, Myelodysplastic Syndromes

NCT02059239 2021-02-21

Bendamustine Bridge to Autologous or Allogeneic Transplant for Relapsed/Refractory Lymphoma

34 enrolled 22 charts

Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin

NCT00858117 2020-11-06

A Phase II Trial of Alemtuzumab and Rituximab in Patients With Previously Untreated CLL

30 enrolled 11 charts

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00536978 2020-09-24

Natural Killer (NK) Cell Adback After Allogeneic Stem Cell Transplant With Campath-IH Plus Chemorx for Patients With Lymphoid Malignancies

22 enrolled 5 charts

Burkitt Lymphoma, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT00983528 2020-08-12

Alemtuzumab and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia

6 enrolled 6 charts

Leukemia, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01269385 2020-06-23

Imprime PGG, Alemtuzumab, and Rituximab in Treating Patients With High Risk Chronic Lymphocytic Leukemia

22 enrolled 9 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00578292 2020-05-01

THALLO

Phase NA Terminated

10 enrolled 15 charts

Lymphoma, Follicular, Thalassemia

NCT00566696 2020-04-14

Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies

LymphoidMyeloidOther hematologic neoplasm

73 enrolled 16 charts

Hemoglobinuria, Hemoglobinuria, Paroxysmal, Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Juvenile

NCT00562328 2020-04-08

Rituximab, Alemtuzumab, and GM-CSF As First-Line Therapy in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia

33 enrolled 12 charts

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT01596699 2020-02-26

Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Phase 2 Terminated

16 enrolled 11 charts

Bone Marrow Failure Disorders, Metabolic Diseases

NCT00553098 2020-02-17

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders

29 enrolled 19 charts

Immunologic Deficiency Syndromes

NCT00040846 2020-01-29

Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies

DermatologicLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcoma

60 enrolled 10 charts

Congenital Abnormalities, Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Myeloproliferative Disorders, Recurrence, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Dendritic Cell Sarcoma, Interdigitating

NCT00368355 2020-01-21

MOHEL

LymphoidMyeloidOther hematologic neoplasm

46 enrolled 12 charts

Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Lymphohistiocytosis, Hemophagocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00048412 2020-01-18

Stem Cell Transplant for Patients With Blood Malignancy Using Donors and Less Toxic Chemotherapy With CAMPATH 1H

LymphoidOther hematologic neoplasmPlasma cell

40 enrolled

Leukemia, Lymphoproliferative Disorders, Multiple Myeloma, Paraproteinemias

NCT00057005 2020-01-18

ADVL

Phase 1 Completed

6 enrolled

Other hematologic neoplasm

Leukemia

NCT00085449 2019-11-27

Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

Phase 1/2 Withdrawn

LymphoidMyeloidOther hematologic neoplasmPlasma cell

Congenital Abnormalities, Burkitt Lymphoma, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms, Plasma Cell, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

NCT01392079 2019-10-24

Subcutaneous Alemtuzumab Combined With Oral Dexamethasone, Followed by Alemtuzumab Maintenance or Allo-SCT in CLL With 17p- or Refractory to Fludarabine

135 enrolled

Chromosome 17 deletion, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00997386 2019-09-09

ALBUM

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

16 enrolled 7 charts

Anemia, Aplastic, Hemoglobinuria, Paroxysmal, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Hematologic Neoplasms, Primary Myelofibrosis

NCT01875237 2019-07-16

Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

LymphoidMyeloidOther hematologic neoplasmPlasma cell

3 enrolled 15 charts

Hodgkin Disease, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Neoplasms, Plasma Cell

NCT00801931 2019-03-27

Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders

CNSClassical hematologyLymphoidOther hematologic neoplasm

1 enrolled 8 charts

Anemia, Immunologic Deficiency Syndromes, Leukemia, Lymphoma, Neuroblastoma

NCT00646854 2019-03-01

ACT-1

Phase 3 Completed

136 enrolled

Lymphoma, T-Cell, Lymphoma, T-Cell, Peripheral

NCT00057967 2019-02-06

Alemtuzumab in Treating Patients With Relapsed or Refractory Advanced Mycosis Fungoides or Sézary Syndrome

37 enrolled

DermatologicLymphoid

Lymphoma, Mycosis Fungoides, Sezary Syndrome, Lymphoma, T-Cell, Cutaneous

NCT00943319 2019-02-04

Busulfan-fludarabine Conditioning and T-cell Depleted Allogeneic Stem Cell Transplantation for Patients With Advanced Hematologic Malignancies

LymphoidOther hematologic neoplasmPlasma cell

50 enrolled 10 charts

Leukemia, Lymphoma, Neoplasms, Plasma Cell

NCT03132584 2019-01-14

Cyclophosphamide and Alemtuzumab In Lymphoma

Phase 1 Terminated

3 enrolled

Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse

NCT00129753 2018-11-08

Alemtuzumab (Campath-1H) Monoclonal Antibody in Patients With Relapsed and Resistant Classical Hodgkin's Disease

Phase 2 Withdrawn

Hodgkin Disease, Lymphoma, Recurrence

NCT00038883 2018-11-07

Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies

Phase NA Terminated

19 enrolled

Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Lymphoma, T-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01049854 2018-08-21

CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

20 enrolled

Bone Marrow Failure Disorders, Anemia, Sickle Cell, Immunologic Deficiency Syndromes, Leukemia, Lymphoma, Metabolism, Inborn Errors, Histiocytosis, beta-Thalassemia

NCT00278213 2018-05-11

Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia

17 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Prolymphocytic, Leukemia, Large Granular Lymphocytic

NCT00626626 2018-04-25

Clofarabine and Non-Myeloablative Allogeneic Hematopoietic Transplantation

LymphoidMyeloidOther hematologic neoplasmPlasma cell

8 enrolled 9 charts

Hodgkin Disease, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphoma, Mantle-Cell

NCT02701517 2017-12-29

Cyclosporine Plus Methotrexate or Alemtuzumab

Phase 2 Terminated

72 enrolled

LymphoidOther neoplasm

Unrecognized Condition: Mature B or T-cell Neoplasm

NCT00565981 2017-12-07

A Pilot Trial With Subcutaneous Alemtuzumab and Oral Fludarabinephosphate for the Determination of Safety, Efficacy and Molecular Profiling for the Prediction of Response

10 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00301834 2017-09-28

Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders

Classical hematologyMyeloidOther hematologic neoplasm

35 enrolled 11 charts

Congenital amegakaryocytic thrombocytopenia, Neutropenia, Severe Congenital, Autosomal Recessive 3, Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Chronic-Phase, Anemia, Diamond-Blackfan

NCT00416884 2017-09-27

Flu,Alemtuzumab,and TBI Followed By Donor Stem Cell Chronic Phase CML

Phase 2 Terminated

1 enrolled 3 charts

Other hematologic neoplasm

Leukemia, Leukemia, Myeloid, Chronic-Phase

NCT00935792 2017-09-26

Everolimus and Alemtuzumab in Treating Patients With Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Other hematologic neoplasm

28 enrolled 13 charts

Leukemia, Lymphoid, Hematologic Neoplasms

NCT02653196 2017-08-17

A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors

Phase EARLY_PHASE1 Terminated

1 enrolled

Neoplasms, Neuroepithelial

NCT00281983 2017-07-24

Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia

100 enrolled

Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00118352 2017-05-30

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

DermatologicLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcoma

12 enrolled 10 charts

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Myeloproliferative Disorders, Recurrence, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Leukemia, Myelomonocytic, Juvenile, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Dendritic Cell Sarcoma, Interdigitating, Intraocular Lymphoma

NCT00555048 2017-05-24

Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer