Clinical Trials Browser

Phase 1 × Completed × Alpelisib × Clear all

NCT01870505 2024-12-09

BYL719 Plus Letrozole or Exemestane for Patients With Hormone-Receptor Positive Locally-Advanced Unresectable or Metastatic Breast Cancer

Phase 1 Completed

52 enrolled 19 charts

Tumor-Agnostic

Neoplasm Metastasis

NCT03207529 2024-10-10

Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer

Phase 1 Completed

18 enrolled

Breast

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT01300962 2023-12-04

Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer

Phase 1 Completed

47 enrolled

Breast

Breast Neoplasms, Neoplasm Metastasis

NCT02273219 2023-08-15

Trial of AEB071 in Combination With BYL719 in Patients With Melanoma

Phase 1 Completed

30 enrolled

Dermatologic

Uveal Melanoma, Melanoma

NCT02282371 2021-10-26

Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)

Phase 1 Completed

16 enrolled

Head & Neck

Head and Neck Squamous Cell Cancer

NCT02167854 2021-07-09

Open-Label Study Evaluating the Safety and Tolerability of LJM716, BYL719 and Trastuzumab in Patients With Metastatic HER2+ Breast Cancer

Phase 1 Completed

23 enrolled

Breast

Breast Neoplasms

NCT02537223 2021-04-19

Phase I Study of BYL719 in Combination With Cisplatin and Radiotherapy in Patients With Squamous Cell Head and Neck Cancer

Phase 1 Completed

9 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02155088 2021-04-08

BYL719 in Combination With Gemcitabine and (Nab)-Paclitaxel in Locally Advanced and Metastatic Pancreatic Cancer

Phase 1 Completed

15 enrolled

Gastrointestinal

Neoplasm Metastasis, Pancreatic Neoplasms, Recurrence

NCT01623349 2021-02-10

Phase I Study of the Oral PI3kinase Inhibitor BKM120 or BYL719 and the Oral PARP Inhibitor Olaparib in Patients With Recurrent Triple Negative Breast Cancer or High Grade Serous Ovarian Cancer

Phase 1 Completed

118 enrolled

BreastGynecologic

Breast Neoplasms, Ovarian Neoplasms, Recurrence

NCT01735968 2020-12-21

A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients

Phase 1 Completed

56 enrolled

Sarcoma

3rd Line GIST

NCT01822613 2020-12-19

Study of Safety & Efficacy of the Combination of LJM716 & BYL719 in Patients With Previously Treated Esophageal Squamous Cell Carcinoma (ESCC)

Phase 1 Completed

48 enrolled

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT02088684 2020-12-17

Study of LEE011 With Fulvestrant and BYL719 or BKM120 in Advanced Breast Cancer

Phase 1 Completed

70 enrolled

Breast

Breast Neoplasms

NCT02144038 2020-12-17

Study of the Safety and Effectiveness of LGH447 and BYL719 in Patients With Relapsed and Refractory Multiple Myeloma

Phase 1 Completed

20 enrolled

Plasma cell

Multiple Myeloma, Recurrence

NCT01613950 2020-12-09

PI3K Inhibitor BYL719 in Combination With the HSP90 Inhibitor AUY922 in Patients With Advanced or Metastatic Gastric Cancer

Phase 1 Completed

18 enrolled

Gastrointestinal

Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein

NCT01928459 2020-12-09

Phase 1b Trial of BGJ398/BYL719 in Solid Tumors

Phase 1 Completed

62 enrolled

Breast

Acrocephalosyndactylia, Breast Neoplasms

NCT01387321 2020-12-08

A Study of BYL719 in Adult Patients With Advanced Solid Malignancies

Phase 1 Completed

33 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT02051751 2020-12-08

A Study to Evaluate the Potential Benefit of the Addition of BYL719 to Paclitaxel in the Treatment of Breast Cancer and Head-and-neck Cancer

Phase 1 Completed

19 enrolled

BreastHead & Neck

Breast Neoplasms, Head and Neck Neoplasms, Neoplasms

NCT02077933 2020-12-08

Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors

Phase 1 Completed

79 enrolled

BreastGenitourinary

Breast Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Neoplasms

NCT01219699 2020-09-22

A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene

Phase 1 Completed

221 enrolled

BreastOther solid neoplasm

Advanced Solid Tumors With an Alteration of the PIK3CA Gene

NCT02038010 2020-06-29

BYL719 + T-DM1 in HER2(+) Metastatic Breast Cancer Pts Who Progress on Prior Trastuzumab & Taxane Tx

Phase 1 Completed

17 enrolled 17 charts

Breast

Breast Neoplasms

NCT02058381 2020-03-09

B-YOND

Phase 1 Completed

40 enrolled

Breast

Pre-menopausal Breast Cancer

NCT01449058 2017-10-02

A Phase Ib Study of MEK162 Plus BYL719 in Adult Patients With Selected Advanced Solid Tumors

Phase 1 Completed

139 enrolled

Other solid neoplasm

Advanced and Selected Solid Tumors