Clinical Trials

845 enrolled

Tumor-Agnostic

Neoplasms

NCT06704724 2026-05-22

A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.

Phase 1 Terminated

30 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06806852 2026-05-20

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

85 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT07535112 2026-05-18

A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

130 enrolled

Gastrointestinal

Advanced/Metastatic Colorectal Adenocarcinoma

NCT05355701 2026-05-14

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

CNSDermatologicHead & NeckThoracic

267 enrolled

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Thyroid Neoplasms

NCT07247110 2026-05-14

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

250 enrolled

Tumor-Agnostic

Neoplasms

NCT07318805 2026-05-08

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

260 enrolled

BreastGastrointestinal

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT07300150 2026-05-07

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

195 enrolled

Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Colorectal Neoplasms

NCT06835569 2026-05-06

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

188 enrolled

Carcinoma, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Pancreatic Neoplasms, Colorectal Neoplasms

NCT06179160 2026-05-04

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

710 enrolled

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT06227377 2026-04-27

QTX3034 in Patients With KRAS G12D Mutation

250 enrolled

Phase 1 Not yet recruiting

Solid Tumors

NCT07543471 2026-04-24

PK similarity

387 enrolled

mCRC

NCT06720987 2026-04-23

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

140 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT07204340 2026-04-21

TLN-372 in Advanced KRAS Mutant Solid Tumors

240 enrolled

KRAS Mutant Solid Tumors

NCT06447662 2026-04-20

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

330 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06586515 2026-04-20

MOONRAY-01

630 enrolled

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT05382559 2026-04-14

A Study of ASP3082 in Adults With Advanced Solid Tumors

681 enrolled

Tumor-Agnostic

Neoplasm Metastasis, Neoplasms

NCT07216105 2026-04-07

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & NeckThoracic

113 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Ovarian Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04670679 2026-03-25

FLAGSHP-1

GastrointestinalHead & NeckSarcoma

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Chordoma, Neoplasm Metastasis, Neoplasms, Noonan Syndrome, Colorectal Neoplasms

NCT06818812 2026-03-23

A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

30 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT06917079 2026-03-23

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

387 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Colorectal Neoplasms

NCT06585488 2026-03-18

A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification

GastrointestinalOther solid neoplasmThoracic

514 enrolled

Metastatic Solid Tumors

NCT06599502 2026-03-18

ALAFOSS-01

Phase 1 Terminated

17 enrolled

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT06715124 2026-03-02

QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations

237 enrolled

Advanced Solid Tumors

NCT07435311 2026-02-27

A Phase I Comparative Study of Pharmacokinetics, Safety, and Efficacy of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma

Phase 1 Completed

118 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT07030959 2026-02-25

Study of AUBE00 in Patients With Solid Tumors

130 enrolled

Solid Tumors

NCT04485013 2026-02-18

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers