Clinical Trials Browser

Phase 2 × INDUSTRY × Denosumab × Clear all

NCT04907539 2025-04-16

A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)

Phase 2 Completed

25 enrolled 22 charts

Gastrointestinal

Colorectal Neoplasms

NCT04907851 2025-03-17

KEYNOTE-E86

Phase 2 Completed

45 enrolled 25 charts

Gastrointestinal

Biliary Tract Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT00396279 2022-11-08

Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone

Phase 2 Completed

37 enrolled 13 charts

Giant Cell Tumor of Bone

NCT00680992 2022-09-22

Study of Denosumab in Subjects With Giant Cell Tumor of Bone

Phase 2 Completed

535 enrolled 16 charts

Giant Cell Tumors, Neoplasms, Giant Cell Tumor of Bone

NCT01951586 2021-10-25

Denosumab in Combination With Chemotherapy as First-line Treatment of Metastatic Non-small Cell Lung Cancer

Phase 2 Completed

226 enrolled 24 charts

Carcinoma, Non-Small-Cell Lung

NCT00896454 2018-10-17

Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

Phase 2 Completed

33 enrolled 22 charts

BreastGastrointestinalGenitourinaryHead & NeckLymphoidPlasma cellThoracic

Humoral Hypercalcemia Of Malignancy, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Hypercalcemia, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Parathyroid Neoplasms, Thyroid Neoplasms

NCT00259740 2017-03-15

Open-Label, Phase 2, Proof of Concept Study in Multiple Myeloma - Denosumab

Phase 2 Completed

96 enrolled 7 charts

Multiple Myeloma, Recurrence

NCT00091832 2014-01-28

Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer

Phase 2 Completed

255 enrolled 34 charts

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00104650 2011-01-24

Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates

Phase 2 Completed

111 enrolled 20 charts

Multiple Myeloma