Clinical Trials

Phase 2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT03944772 2025-01-30

ORCHARD

247 enrolled

Carcinoma, Non-Small-Cell Lung

NCT01610336 2021-04-08

A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment

161 enrolled 32 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01466660 2020-04-07

LUX-Lung 7: A Phase IIb Trial of Afatinib(BIBW2992) Versus Gefitinib for the Treatment of 1st Line EGFR Mutation Positive Adenocarcinoma of the Lung

319 enrolled 19 charts

Lung Neoplasms

NCT02976116 2019-11-15

A Phase II Study of Fruquintinib in Combination With Gefitinib in Patients With Advanced Non-small Cell Lung Cancer

50 enrolled

NSCLC

NCT01469000 2019-09-10

A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC)

195 enrolled 17 charts

Carcinoma, Non-Small-Cell Lung

NCT02179671 2019-08-02

Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

32 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00059722 2016-08-24

This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.

160 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT01530334 2016-02-23

ICARUS

61 enrolled 11 charts

Lung Neoplasms

NCT00229697 2015-10-05

Phase II Metastatic ER+/PgR+ Nolvadex +/- Iressa Study

317 enrolled

Breast Neoplasms

NCT00077025 2014-07-16

Comparing Anastrozole-Placebo to the Combination Anastrozole-ZD1839 in Postmenopausal Patients With Estrogen Receptor and/or Progesterone Receptor Metastatic Breast Cancer

174 enrolled

Breast Neoplasms

NCT00265070 2013-02-05

Trial of Iressa in Prostate Cancer Patients

80 enrolled

Prostatic Neoplasms

NCT00787410 2012-06-06

An Open-label, Phase II Trial of ZD1839 (IRESSA) in Patients With Malignant Mesothelioma

Other solid neoplasmThoracic

23 enrolled

Mesothelioma, Malignant, Mesothelioma

NCT01391260 2011-08-02

Radiotherapy Combined With Iressa for EGFR Mutation Positive Patients With Locally Advanced Non-small Cell Lung Cancer (NSCLC)

Phase 2 Unknown

30 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00252811 2011-01-28

A Study of ZD1839 Effects on Cell Proliferation in Breast Cancer

Phase 2 Withdrawn

60 enrolled

Breast Neoplasms

NCT00233623 2011-01-27

Irinotecan, 5-Fluorouracil and Leucovorin With or Without Iressa in the Treatment of Metastatic Colorectal Cancer

Phase 2 Withdrawn

190 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT00233636 2011-01-27

Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell Carcinoma of the Head and Neck

Phase 2 Withdrawn

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00239343 2011-01-27

Phase II Trial of Preoperative Therapy With Gefitinib and Chemotherapy in Patients With ERneg Breast Cancer

160 enrolled

Breast Neoplasms

NCT00242762 2011-01-27

ZD1839 (IRESSA™) in Combination With Docetaxel & Cisplatin in Subjects With Metastatic Head & Neck Cancer

36 enrolled

Head and Neck Neoplasms

NCT00319787 2011-01-25

Combination Casodex® and Iressa™ in Locally Advanced Prostate Cancer

102 enrolled

Locally Advanced Prostate Cancer

NCT00238797 2011-01-21

A Phase II Exploratory, Multicentre, Open-label, Non-comparative Study of ZD1839 (Iressa) and Radiotherapy in the Treatment of Patients With Glioblastoma Multiforme

36 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT00409006 2010-09-09

Chemotherapy for Patients With Non-Small Cell Lung Cancer Who Are Non-Smokers

70 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung

NCT00344773 2010-06-29

First-line Treatment for Adenocarcinoma Patients With Epidermal Growth Factor Receptor (EGFR) Mutation

46 enrolled 7 charts

Lung Neoplasms, Neoplasm Metastasis

NCT00229723 2009-08-04

IRESSA™ (Gefitinib) With Cisplatin Plus Radiotherapy for the Treatment of Previously Untreated Unresected Late Stage III/IV Non-Metastatic Head and Neck Squamous Cell Carcinoma

224 enrolled 21 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Neoplasms, Squamous Cell

NCT00264498 2009-08-03

Phase II Iressa & Carbo/Gem in NSCLC

38 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00234442 2009-06-30

Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer

Phase 2 Terminated

47 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT00234403 2009-04-23

A Trial to Evaluate the Combination of Iressa & Faslodex® in Patients With Advanced or Metastatic Breast Cancer

60 enrolled

Breast Neoplasms

NCT00241475 2009-04-23

Gefitinib in the Treatment of the First Relapse of Prostate Cancer Beyond Prostatectomy or Radiotherapy

30 enrolled

Prostatic Neoplasms

NCT00242749 2009-04-23

IRESSA in Combination With Cisplatin & Radiotherapy in Patients With Advanced Head & Neck Carcinoma

47 enrolled

Head and Neck Neoplasms

NCT00247481 2009-04-23

ZD1839 (Iressa™) In Combination With Docetaxel As First-Line Treatment In Patients With Metastatic Breast Cancer

77 enrolled

Breast Neoplasms

NCT00255463 2009-04-23

Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa Study

185 enrolled

Breast Neoplasms

NCT00255476 2009-04-23

The IRESSA Novel Head and Neck Chemotherapy Evaluation Study

64 enrolled

Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT00256711 2009-04-23

Phase II Iressa Versus Vinorelbine (INVITE)

192 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00635856 2009-04-23

Open Label Trial to Assess Iressa in Prostate Cancer Patients

100 enrolled

Prostatic Neoplasms

NCT00637026 2009-04-23

Ph II Early BC Pre-Surgical Biologic Study

65 enrolled

Breast Neoplasms

NCT00632723 2009-04-22

IRESSA™ (Gefitinib) in Breast Cancer Patients

54 enrolled

Breast Neoplasms

NCT00246974 2008-10-15

Phase II Gemcitabine + Cisplatin +/- Iressa Bladder CCT

125 enrolled

Urinary Bladder Neoplasms

NCT00298688 2008-06-12

A Study of IRESSA in Relapsed and Refractory Small Cell Lung Cancer

56 enrolled

Small Cell Lung Carcinoma

NCT00228488 2007-12-19

Effect of Iressa With/Without Concurrent Chemoradiotherapy on Tumor Gene Expression Profiles in Patients With Advanced Non-Nasopharyngeal Head and Neck Carcinoma

60 enrolled

Head and Neck Neoplasms

NCT00333294 2007-12-19

Phase II Iressa + Irradiation Followed by Chemo in NSCLC

50 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00319618 2007-12-18

Combination Weekly Taxotere™ With Iressa™ /Placebo in Metastatic Breast Cancer

66 enrolled