Clinical Trials Browser

Terminated × INDUSTRY × Irinotecan × Clear all

NCT04924192 2026-04-13

A Clinical Study of TQB3616 Capsules Combined With Anlotinib Hydrochloride Capsules or Standard Chemotherapy Second-line and Above in the Treatment of Advanced Lung Cancer

Phase 2 Terminated

Advanced Lung Carcinoma

NCT06509906 2025-12-18

M9466 in Combination With Topoisomerase 1 Inhibitors-based Regimens in Advanced Solid Tumors and Colorectal Cancer (DDRiver 511)

Phase 1 Terminated

Other solid neoplasm

Advanced Solid Tumor

NCT04239092 2025-07-17

9-ING-41 in Pediatric Patients With Refractory Malignancies.

Phase 1 Terminated

Diffuse Intrinsic Pontine Glioma, Meningioma, Neoplasms, Neuroblastoma

NCT05330429 2025-07-01

ELEVATE CRC

Phase 2 Terminated

77 enrolled 22 charts

Gastrointestinal

Colorectal Neoplasms

NCT05461794 2025-06-13

Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma

Phase 2 Terminated

96 enrolled 17 charts

Gastrointestinal

Esophageal Squamous Cell Carcinoma

NCT04553692 2025-03-28

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

Phase 1 Terminated

GastrointestinalLymphoidOther hematologic neoplasmSarcoma

Chondrosarcoma, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT04492033 2025-01-27

A Study of CTX-009 (ABL001) in Combination With Irinotecan or Paclitaxel in Advanced or Metastatic Solid Tumor Patients

Phase 1/2 Terminated

GastrointestinalOther solid neoplasm

P1b: Advanced Solid Tumors

NCT03009058 2024-11-25

MODULATE

Phase 1/2 Terminated

2 enrolled 7 charts

DermatologicSarcoma

Melanoma, Neoplasm Metastasis, Sarcoma

NCT04525014 2024-10-31

PIRATE

Phase 1 Terminated

Brain Neoplasms, Neoplasms, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT05824455 2024-09-05

A Clinical Study of IMP4297 Capsule (JS109) Combined With Irinotecan in the Treatment of Advanced Malignant Solid Tumors

Phase 1/2 Terminated

Other solid neoplasm

Advanced Solid Tumors

NCT05039944 2024-07-18

SI-B001 as a Single Agent or in Combination With Chemotherapy in the Treatment of Digestive System Malignancies

Phase 2 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT00838578 2024-04-26

Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer

Phase 1/2 Terminated

65 enrolled 7 charts

Gastrointestinal

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT05148195 2024-03-13

A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors

Phase 2 Terminated

Other solid neoplasm

Advanced Solid Tumor

NCT01133990 2023-11-07

FOLFIRI Alone Versus FOLFIRI Plus Bevacizumab Versus FOLFIRI Plus E7820 as Second-Line Therapy in Patients With Locally Advanced or Metastatic Colorectal Cancer

Phase 1/2 Terminated

5 enrolled 12 charts

Gastrointestinal

Colorectal Neoplasms

NCT03495921 2023-04-26

VITA

Phase 3 Terminated

32 enrolled 13 charts

Neoplasms, Neoplasms by Histologic Type, Neoplasms, Connective Tissue, Sarcoma, Sarcoma, Ewing, Neoplasms, Connective and Soft Tissue, Neoplasms, Bone Tissue, Neuroectodermal Tumors, Primitive, Peripheral, Rare Diseases

NCT02801097 2022-05-17

PAYLOAD

Phase 1 Terminated

Neoplasm Metastasis

NCT04627142 2022-04-20

A Study to Test Different Doses of BI 1701963 in Combination With Irinotecan in People With Advanced Bowel Cancer With Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Mutation

Phase 1 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT03368859 2021-02-09

A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab

Phase 2 Terminated

70 enrolled 12 charts

Gastrointestinal

Intestinal Neoplasms, Neoplasms, Colorectal Neoplasms

NCT03096340 2020-12-22

Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer

Phase 1 Terminated

Neoplasms

NCT01836432 2020-05-28

PILLAR

Phase 3 Terminated

Gastrointestinal

Pancreatic Neoplasms

NCT02405585 2020-05-28

Immunotherapy and SBRT Study in Borderline Resectable Pancreatic Cancer

Phase 2 Terminated

Gastrointestinal

Pancreatic Neoplasms

NCT01609231 2020-05-04

MK-0646-025

Phase 2 Terminated

11 enrolled 8 charts

Gastrointestinal

Rectal Neoplasms

NCT01479465 2019-04-17

Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma

Phase 2 Terminated

266 enrolled 15 charts

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT02568046 2019-03-26

Sym004 in Combination With FOLFIRI in Metastatic Colorectal Cancer Patients

Phase 1/2 Terminated

10 enrolled 14 charts

Gastrointestinal

Colorectal Neoplasms

NCT01925274 2019-01-08

A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal Cancer

Phase 2 Terminated

19 enrolled 32 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT01347866 2018-10-29

Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer

Phase 1 Terminated

105 enrolled 64 charts

Advanced Cancer

NCT00816777 2018-09-07

PARAGON

Phase 1/2 Terminated

4 enrolled 5 charts

Gastrointestinal

Carcinoma, Colonic Neoplasms, Gastrointestinal Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT00960063 2018-08-27

A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

Phase 1 Terminated

4 enrolled 8 charts

CNSGenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Neoplasms, Neuroblastoma

NCT00954512 2018-08-24

Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Participants With Advanced Solid Tumors (P04722, MK-7454-004)

Phase 1/2 Terminated

15 enrolled 11 charts

Neoplasms

NCT00845039 2018-07-02

FC-4

Phase 2 Terminated

4 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00642603 2018-03-29

A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal Cancer

Phase 2 Terminated

41 enrolled 6 charts

Gastrointestinal

Colorectal Neoplasms

NCT01813253 2018-03-26

Phase 3 Study of Nimotuzumab and Irinotecan as Second Line With Advanced or Recurrect Gastric and Gastroesophageal Junction Cancer

Phase 3 Terminated

Gastrointestinal

Stomach Neoplasms

NCT01765582 2017-09-18

STEAM

Phase 2 Terminated

280 enrolled 15 charts

Gastrointestinal

Colorectal Neoplasms

NCT00040391 2016-12-01

A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer

Phase 2 Terminated

Gastrointestinal

Diarrhea, Colorectal Neoplasms

NCT00811993 2016-11-02

A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors

Phase 1 Terminated

Neoplasms

NCT02060955 2016-06-06

Randomized Phase 2 Study to Investigate Efficacy of ALECSAT in Patients With GBM Measured Compared to Avastin/Irinotecan

Phase 2 Terminated

Glioblastoma, Recurrence

NCT00006269 2012-05-25

Octreotide in the Prevention of Diarrhea in Patients Receiving Irinotecan for Metastatic Colon Cancer

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Diarrhea, Rectal Neoplasms, Colorectal Neoplasms

NCT00969033 2012-01-31

CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic Colorectal Carcinoma Who Failed First-line Treatment With Oxaliplatin

Phase 2 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT00473616 2011-02-11

Phase I Single Ascending Dose/Multiple Ascending Dose in Patients Treated With AZD7762 and Irinotecan

Phase 1 Terminated

Neoplasms

NCT00037180 2008-09-29

For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With Chemotherapy

Phase 2 Terminated

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT00044785 2005-06-24

Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors

Phase 1 Terminated

BreastGastrointestinal

Breast Neoplasms, Stomach Neoplasms, Colorectal Neoplasms