Clinical Trials Browser

Phase 1 × Lapatinib × Clear all

NCT01947023 2025-11-05

Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery

Phase 1 Active not recruiting

Thyroid Neoplasms

NCT04608409 2025-06-29

Dose Escalation of Lapatinib With Paclitaxel in Ovarian Cancer

Phase 1 Completed

16 enrolled 14 charts

Ovarian Neoplasms

NCT02101905 2024-11-06

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Phase 1 Completed

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00963547 2024-06-04

MK-2206-015

Phase 1 Terminated

33 enrolled 13 charts

Breast Neoplasms

NCT01199367 2024-04-25

Safety, Tolerability, and Efficacy Study in Subjects With Advanced or Metastatic Breast Cancer

Phase 1 Terminated

Breast Neoplasms

NCT00424164 2024-03-08

LAPATAM

Phase 1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT01300962 2023-12-04

Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis

NCT00251433 2023-03-31

GW572016 With Docetaxel and Trastuzumab for the Treatment Of Untreated ErbB2 Over-Expressing Metastatic Breast Cancer

Phase 1 Terminated

Breast Neoplasms

NCT00807859 2022-11-08

Safety Study of AMG 386 to Treat HER2-positive Locally Recurrent or Metastatic Breast Cancer

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00447122 2022-03-08

BrUOG-PA-209: Lapatinib and Gemcitabine for Metastatic Pancreaticobiliary Cancer

Phase 1 Terminated

25 enrolled 9 charts

Gastrointestinal

Pancreatic Neoplasms

NCT02650752 2021-01-26

Intermittent High-Dose Lapatinib in Tandem With Capecitabine for HER2 Overexpressed/Amplified Metastatic Breast Cancer With Central Nervous System (CNS) Metastases

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis

NCT01471847 2020-12-09

A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis

NCT00367471 2020-09-09

Combination Of Lapatinib With Carboplatin, Paclitaxel, and With or Without Trastuzumab In Metastatic Breast Cancer.

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis

NCT00085020 2020-08-03

GW572016 and Trastuzumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER2/Neu

Phase 1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT00543504 2020-06-30

Bevacizumab in Multiple Phase I Combinations

Phase 1 Completed

Advanced Cancer

NCT01434303 2019-05-20

Entinostat, Lapatinib Ditosylate and Trastuzumab in Treating Patients With Locally Recurrent or Distant Relapsed Metastatic Breast Cancer Previously Treated With Trastuzumab Only

Phase 1 Completed

Breast Neoplasms

NCT02073916 2019-04-16

STELA

Phase 1 Completed

Breast Neoplasms

NCT00371488 2018-08-31

GW572016 Combined With Trastuzumab For The Treatment Of Previously Trastuzumab-Treated Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00462956 2018-08-31

GW572016 In Patients With Advanced Or Metastatic Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00790816 2018-02-28

Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents

Phase 1 Completed

Breast Neoplasms, Neoplasms

NCT00536809 2017-12-18

Phase I/II Study of Lapatinib in Combination With Oxaliplatin and Capecitabine in Subjects With Advanced Colorectal Cancer

Phase 1 Completed

12 enrolled 6 charts

Gastrointestinal

Colorectal Neoplasms

NCT00148902 2017-12-06

Effects Of GW572016 In Combination With Docetaxel (TAXOTERE)

Phase 1 Completed

Breast Neoplasms, Neoplasms

NCT00258050 2017-12-06

To Examine The Effects Of Lapatinib On Orally And Intravenously Administered Midazolam In Cancer Patients

Phase 1 Completed

Breast Neoplasms

NCT00158782 2017-11-17

Study Of Safety And Tolerability Of GW786034 Given With Lapatinib In Cancer Patients

Phase 1 Completed

Carcinoma, Renal Cell

NCT00169533 2017-11-17

Rollover Study Of Lapatinib In Cancer Patients

Phase 1 Completed

Breast Neoplasms

NCT00388076 2017-11-17

Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)

Phase 1 Completed

Breast Neoplasms

NCT00528281 2017-11-17

A Phase II Trial of Lapatinib (TYKERB) + Pemetrexed (ALIMTA) in Advanced Non Small Cell Lung Cancer With an Initial Dose Finding Phase

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung

NCT00650910 2017-11-17

Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00849329 2017-11-14

A Study to Examine the Effects of Esomeprazole on the Pharmacokinetics of Orally Administered Lapatinib in Subjects With Metastatic ErbB2 Positive Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00359190 2017-11-13

Pharmacokinetics And Pharmacodynamics Of Lapatinib In Two Dosing Regimens In Treatment-naive Patients With Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00516672 2017-11-13

Phase I Study of Pazopanib Alone and In Combination With Lapatinib in Japanese Patients With Solid Tumors

Phase 1 Completed

Carcinoma, Renal Cell, Neoplasms

NCT00821054 2017-11-13

A Study to Examine the Effects of Low and High-fat Meals on Orally Administered Lapatinib in Metastatic ErbB2 Positive Breast Cancer Patients

Phase 1 Completed

Breast Neoplasms

NCT00996762 2017-11-13

A Study in Cancer Patients to Evaluate the Bioequivalence of Alternative Formulations of Lapatinib

Phase 1 Completed

Breast Neoplasms

NCT01290354 2017-11-13

Exploratory Lapatinib (Positron Emission Tomography) PET Study in Subjects With Breast Cancer

Phase 1 Completed

Neoplasms

NCT00662636 2017-03-23

Dasatinib and Lapatinib Ditolsylate in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery

Phase 1 Completed

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00379509 2017-03-21

Lapatinib and Radiation Therapy in Treating Patients With Locally Recurrent or Chemotherapy-Refractory Locally Advanced or Metastatic Breast Cancer

Phase 1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT01454804 2016-04-13

Pazopanib, Lapatinib or Trastuzumab in Subjects With Solid Tumors

Phase 1 Completed

Advanced Cancers

NCT00634088 2016-03-10

Phase I Study of Ixabepilone Plus Lapatinib With or Without Capecitabine in the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Phase 1 Terminated

13 enrolled 13 charts

Breast Neoplasms

NCT01497626 2016-02-17

Lapatinib and Bortezomib in Patients With Advanced Malignancies

Phase 1 Terminated

Other solid neoplasm

Advanced Solid Tumors

NCT00753207 2016-02-15

Lapatinib and Epirubicin in Treating Patients With Metastatic Breast Cancer. ICORG 06-30

Phase 1 Completed

Breast Neoplasms

NCT02131506 2016-02-02

CAELYX

Phase 1 Terminated

Breast Neoplasms

NCT01304784 2015-12-16

A Study of MM-111 in Combination With Multiple Treatments in Patients With HER2 Positive Cancer

Phase 1 Completed

HER-2 Gene Amplification

NCT01087983 2015-11-11

Lapatinib With Sirolimus or Metformin

Phase 1 Completed

Neoplasm Metastasis

NCT01281163 2015-08-27

Lapatinib Ditosylate and Akt Inhibitor MK2206 in Treating Women With Metastatic Breast Cancer

Phase 1 Terminated

Breast Neoplasms

NCT00632489 2015-06-08

LBH589 in Combination With Capecitabine Plus/Minus (±) Lapatinib in Breast Cancer Patients

Phase 1 Completed

20 enrolled 5 charts

Breast Neoplasms, Neoplasms

NCT00682279 2015-04-17

A Phase I Study Of Oral Topotecan And Lapatinib In Subjects With Advanced Solid Tumors

Phase 1 Withdrawn

Other solid neoplasm

Advanced Solid Tumors

NCT00352443 2015-03-06

S0528 Lapatinib and Everolimus in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Completed

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Immunoblastic Lymphadenopathy, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell

NCT00984425 2014-12-02

The Treatment of Lapatinib in Combination With Sorafenib in Patients With Advanced Refractory Solid Tumors

Phase 1 Completed

Other solid neoplasm

Solid Tumors

NCT01238029 2014-11-21

CELAVIE

Phase 1 Terminated

Breast Neoplasms

NCT01245205 2014-10-23

Akt Inhibitor MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast Cancer

Phase 1 Completed

Breast Neoplasms, Breast Neoplasms, Male