Clinical Trials Browser

Immunoblastic Lymphadenopathy, Waldenstrom Macroglobulinemia, Multiple Myeloma, Leukemia, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Enteropathy-Associated T-Cell Lymphoma

NCT01844583 2019-03-25

Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib

Phase 1 Completed

55 enrolled 29 charts

Lymphoid

Lymphoma

NCT00651664 2019-03-15

A Phase I Clinical and Pharmacodynamic Study of MLN8237, A Novel Aurora A Kinase Inhibitor, in Participants With Advanced Malignancies

Phase 1 Completed

59 enrolled 51 charts

Advanced Malignancies

NCT01512758 2019-03-15

A Study of Alisertib (MLN8237) in Adult East Asian Participants With Advanced Solid Tumors or Lymphomas

Phase 1 Completed

36 enrolled 24 charts

Lymphoid

Lymphoma

NCT00500903 2019-03-14

A Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Participants With Advanced Solid Tumors

Phase 1 Completed

87 enrolled 68 charts

Advanced Malignancies

NCT00962091 2019-03-12

Study of MLN8237 in Participants With Advanced Solid Tumors

Phase 1 Completed

53 enrolled 30 charts

Other solid neoplasm

Advanced Solid Tumors

NCT01094288 2019-02-15

A Phase 1 Study of Alisertib Participants With Advanced Solid Tumors Including Castration-Resistant Prostate Cancer Receiving a Standard Docetaxel Regimen

Phase 1 Completed

41 enrolled 31 charts

GenitourinaryOther solid neoplasm

Advanced Solid Tumors

NCT01897012 2019-01-28

Alisertib and Romidepsin in Treating Patients With Relapsed or Refractory B-Cell or T-Cell Lymphomas

Phase 1 Completed

26 enrolled

Lymphoid

Burkitt Lymphoma, Hodgkin Disease, Lymphoma, Follicular, Lymphoma, B-Cell, Lymphoma, T-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT01923337 2019-01-04

Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer

Phase 1 Completed

17 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02214147 2018-11-15

Pharmacokinetics of Alisertib in Adults With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Function

Phase 1 Completed

36 enrolled 26 charts

Lymphoid

Lymphoma

NCT01714947 2018-10-31

Mass Balance, Pharmacokinetics and Metabolism Study of Alisertib

Phase 1 Completed

3 enrolled 32 charts

Lymphoid

Lymphoma

NCT02319018 2018-10-09

Alisertib and Combination Chemotherapy in Treating Patients With Gastrointestinal Tumors

Phase 1 Completed

14 enrolled

Gastrointestinal

Gastrointestinal Neoplasms

NCT02219789 2018-10-03

Alisertib and Fulvestrant in Treating Patients With Hormone Receptor Positive Breast Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

Phase 1 Completed

10 enrolled

Breast

Breast Neoplasms

NCT01540682 2018-08-29

MLN8237 in Head and Neck Cancer

Phase 1 Completed

9 enrolled

Head & Neck

Head and Neck Neoplasms, Laryngeal Diseases

NCT01567709 2018-04-11

Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma

Phase 1 Completed

34 enrolled

DermatologicLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, T-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Intraocular Lymphoma

NCT01677559 2018-01-11