Clinical Trials Browser

Lymphadenopathy, Anemia, Fatigue, Fever, Lymphocytosis, Multiple Myeloma, Splenomegaly, Thrombocytopenia, Weight Loss, Leukemia, Lymphocytic, Chronic, B-Cell

NCT02244567 2021-02-02

U-C OC IN PCOS

Phase 1 Unknown

100 enrolled

Polycystic Ovary Syndrome

NCT01981525 2020-12-14

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Phase 1 Completed

26 enrolled

Li-Fraumeni Syndrome

NCT04621669 2020-11-09

Drug-durg Interaction of SHR3680 With Digoxin, Rosuvastatin Calcium and Metformin Hydrochloride

Phase 1 Unknown

18 enrolled

Drug-drug Interaction,SHR3680

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 1 Completed

20 enrolled 11 charts

Head & Neck

Head and Neck Neoplasms

NCT02050009 2019-02-20

Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 1 Withdrawn

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

NCT01849276 2019-01-31

Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Phase 1 Terminated

2 enrolled 9 charts

Other hematologic neoplasm

Congenital Abnormalities, Blast Crisis, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT03465345 2018-08-03

Study of Metformin Plus Oligomeric Procyanidin Complex for Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients

Phase 1 Withdrawn

Genitourinary

Prostatic Neoplasms

NCT02086526 2018-03-19

Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET)

Phase 1 Completed

68 enrolled

Polycystic Ovary Syndrome

NCT02149459 2017-10-27

SMC 0712-13

Phase 1 Unknown

18 enrolled

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Insulin Resistance, Ketosis

NCT01650506 2017-08-30

Study of Erlotinib and Metformin in Triple Negative Breast Cancer

Phase 1 Completed

8 enrolled

Breast

Breast Neoplasms

NCT01324180 2017-08-07

Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)

Phase 1 Completed

14 enrolled

LymphoidOther hematologic neoplasm

Recurrence, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01442870 2017-05-09

Evaluation of Clinical Safety of Combining Metformin With Anticancer Chemotherapy

Phase 1 Completed

105 enrolled

Tumor-Agnostic

Neoplasms

NCT00933309 2016-02-19

The Impact of Obesity and Obesity Treatments on Breast Cancer

Phase 1 Completed

25 enrolled

BreastOther

Breast Neoplasms, Obesity

NCT01816659 2015-11-18

An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin

Phase 1 Terminated

3 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT01087983 2015-11-11

Lapatinib With Sirolimus or Metformin

Phase 1 Completed

111 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT01954732 2015-07-15

Metformin Hydrochloride in Treating Patients With Pancreatic Cancer That Can be Removed by Surgery

Phase 1 Withdrawn

Gastrointestinal

Pancreatic Neoplasms

NCT01440127 2015-03-26

Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers

Phase 1 Terminated

9 enrolled

Gastrointestinal

Colonic Neoplasms

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Phase 1 Completed

28 enrolled

BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma

NCT01693289 2012-09-26

Study to Compare Between Combimed Metformin-letrozole and Ovarian Drilling in Pcos With Bilateral Ovarian Drilling in Clomiphene-resistant Infertile Women With Polycystic Ovarian Syndrome

Phase 1 Completed

146 enrolled

Polycystic Ovary Syndrome

Clinical Trials

NAE-PCOS

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study

PCOS

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

Enzalutamide and Metformin Hydrochloride in Treating Patients With Hormone-Resistant Prostate Cancer

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Temsirolimus in Combination With Metformin in Patients With Advanced Cancers

PCOS

Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myeloma

OVMET

Insulin Sensitizers Role in Control of PCOS Vicious Cycle.

Sapanisertib and Metformin in Treating Patients With Advanced or Metastatic Relapsed or Refractory Cancers

Metformin in Children With Relapsed or Refractory Solid Tumors

Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer

A Pharmacokinetic Interaction Study Between Apatinib and Rosuvastatin or Metformin in Solid Tumor Subjects.

A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer

Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia

U-C OC IN PCOS

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Drug-durg Interaction of SHR3680 With Digoxin, Rosuvastatin Calcium and Metformin Hydrochloride

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Study of Metformin Plus Oligomeric Procyanidin Complex for Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients

Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET)

SMC 0712-13

Study of Erlotinib and Metformin in Triple Negative Breast Cancer

Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)

Evaluation of Clinical Safety of Combining Metformin With Anticancer Chemotherapy

The Impact of Obesity and Obesity Treatments on Breast Cancer

An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin

Lapatinib With Sirolimus or Metformin

Metformin Hydrochloride in Treating Patients With Pancreatic Cancer That Can be Removed by Surgery

Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Study to Compare Between Combimed Metformin-letrozole and Ovarian Drilling in Pcos With Bilateral Ovarian Drilling in Clomiphene-resistant Infertile Women With Polycystic Ovarian Syndrome