Clinical Trials Browser

Interventional × Methadone × Clear all

NCT06810336 2026-05-04

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

Phase EARLY_PHASE1 Recruiting

Brain Injuries, Brain Neoplasms, Pain

NCT03574792 2026-04-16

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Phase 2 Completed

62 enrolled 10 charts

DermatologicHead & Neck

Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

NCT06525740 2026-03-04

Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

Phase 4 Recruiting

Malignant Female Reproductive System Neoplasm

NCT05417100 2026-01-27

Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery

Phase 3 Active not recruiting

Spinal Surgery

NCT06536517 2026-01-12

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.

Phase 2 Recruiting

Leiomyoma

NCT07092475 2025-11-26

The Impact of Intraoperative Methadone on Postoperative Opioid Use

Phase 3 Withdrawn

Breast Neoplasms

NCT06940570 2025-10-23

MATCH

Phase 3 Suspended

Classical hematologyOtherOther hematologic neoplasm

Bone Marrow Failure Disorders, Anemia, Aplastic, Leukemia, Neoplasms, Pain, Intractable, Mucositis

NCT01793480 2024-10-31

EQUIMETH2

Phase 3 Completed

Pain Related to Cancer

NCT00930332 2024-02-12

Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain

Phase 1 Terminated

Nausea, Pain, Sleep Wake Disorders, Vomiting

NCT04475029 2023-09-13

METAMORF

Phase NA Completed

Urinary Bladder Neoplasms, Neurologic Manifestations, Pain, Pain, Postoperative, Pathologic Processes, Postoperative Complications, Signs and Symptoms

NCT05251376 2023-01-19

Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy

Phase 1 Withdrawn

Lymphoma, Follicular, Opioid-Related Disorders

NCT05325164 2022-12-05

METHADOPT

Phase 3 Withdrawn

Cancer Pain, Adenocarcinoma, Neoplasms

NCT02531906 2022-07-25

Gabapentin, Methadone Hydrochloride, and Oxycodone Hydrochloride in Improving Quality of Life in Patients With Stage II-IV Head and Neck Cancer During Chemoradiation

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck, Pain, Stomatitis

NCT00726830 2020-09-24

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Phase NA Terminated

1 enrolled 3 charts

CNSDermatologicLymphoidMyeloidOther hematologic neoplasmOther neoplasmPlasma cell

Pdgfra-Associated Chronic Eosinophilic Leukemia, Congenital Abnormalities, Immunoglobulin Light-chain Amyloidosis, Blast Crisis, Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, Mycosis Fungoides, Myelodysplastic Syndromes, Myeloproliferative Disorders, Pain, Polycythemia Vera, Precancerous Conditions, Sezary Syndrome, Thrombocythemia, Essential, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Prolymphocytic, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Central Nervous System Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms, Plasma Cell, Lymphoma, Extranodal NK-T-Cell, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis, Intraocular Lymphoma

NCT03324815 2017-10-30

Methadone Associated With Morphine for Cancer Pain

Phase NA Unknown

Neoplasms, Pain

NCT00125294 2017-09-25

Sublingual Methadone for the Management of Cancer Breakthrough Pain

Phase 1 Completed

Cancer Pain, Neoplasms, Pain, Breakthrough Pain

NCT02958566 2017-03-20

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Phase 4 Unknown

GastrointestinalOther

Agnosia, Colonic Neoplasms, Constipation, Diverticulitis, Colonic, Pain, Postoperative, Rectal Neoplasms, Diverticulosis, Colonic, Ileus

NCT02687347 2016-09-20

UDOME

Phase 3 Unknown

Pain, Intractable

NCT00634010 2016-05-09

Morphine Versus Methadone As First Line Strong Opioid for Cancer Pain

Phase 3 Terminated

36 enrolled 6 charts

Cancer Pain

NCT00558870 2016-04-05

Role of Methadone As Co-Opioid Analgesic

Phase 2 Terminated

5 enrolled 4 charts

Pain

NCT00573937 2016-02-19

Methadone Versus Morphine for Cancer-Related Pain

Phase 2 Terminated

1 enrolled 2 charts

Neoplasms, Pain

NCT01317589 2015-07-16

310111-4

Phase 4 Completed

Head and Neck Neoplasms, Pain

NCT02335398 2015-01-09

Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management

Phase 4 Completed

Cancer Pain, Chronic Pain

NCT00184496 2014-02-28

Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study

Phase 3 Completed

Neoplasms

NCT00525967 2007-09-06

Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain

Phase 2/3 Unknown

Cancer Pain, Neoplasms, Pain