Clinical Trials

23 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Nasopharyngeal Neoplasms

NCT01397877 2023-09-06

ENDOPIK

24 enrolled

Gynecologic

Neoplasm Metastasis, Endometrial Neoplasms

NCT01971489 2023-04-27

Buparlisib, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Advanced Solid Tumors

Phase 1 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT01570296 2023-03-29

BKM120

38 enrolled

Carcinoma, Non-Small-Cell Lung

NCT02756247 2022-10-10

A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma

37 enrolled

Lymphoma, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT02117817 2022-07-28

Phase I BKM120/Abraxane in Solid Tumors, Expansion Phase Recurrent Endometrial or Ovarian Cancer

Phase 1 Withdrawn

Gynecologic

Ovarian Neoplasms, Endometrial Neoplasms

NCT01540253 2022-07-22

PI3K Inhibitor BKM120 and Docetaxel in Treating Patients With Advanced Solid Tumor That is Locally Advanced, Cannot Be Removed By Surgery, or Metastatic

38 enrolled

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT02049541 2022-06-30

Study of BKM120 & Rituximab in Patients With Relapsed or Refractory Indolent B-Cell Lymphoma

18 enrolled

Lymphoma, Follicular, Waldenstrom Macroglobulinemia, Lymphoma, B-Cell, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT02220855 2022-04-11

A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas

14 enrolled 14 charts

Thymoma

NCT01806649 2021-10-11

BKM120 in Esophageal Squamous Cell Carcinoma After Failure of First Line Chemotherapy

5 enrolled

Gastrointestinal

Esophageal Neoplasms

NCT01816984 2021-10-05

PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Phase 1/2 Completed

12 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01623349 2021-02-10

Phase I Study of the Oral PI3kinase Inhibitor BKM120 or BYL719 and the Oral PARP Inhibitor Olaparib in Patients With Recurrent Triple Negative Breast Cancer or High Grade Serous Ovarian Cancer

118 enrolled

BreastGynecologic

Breast Neoplasms, Ovarian Neoplasms, Recurrence

NCT01695473 2021-01-13

Neoadjuvant BKM120 in High-risk Prostate Cancer

11 enrolled 8 charts

Prostatic Neoplasms

NCT01629615 2020-10-28

A Trial of BKM120 (a PI3K Inhibitor) in Patients With Triple Negative Metastatic Breast Cancer

50 enrolled 10 charts

LymphoidOther hematologic neoplasm

Breast Neoplasms, Neoplasm Metastasis, Triple Negative Breast Neoplasms

NCT01349660 2020-06-17

Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme

Phase 1/2 Completed

88 enrolled 13 charts

CNS

Glioblastoma

NCT02614508 2019-09-03

Buparlisib and Ofatumumab or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Phase 1 Terminated

1 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02128724 2019-08-01

BKM120

21 enrolled 23 charts

Hypoxia, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01737450 2019-06-24

PIK-ORL

58 enrolled

Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence, Disease Progression

NCT01339052 2019-03-19

Phase II Study of BKM120 for Subjects With Recurrent Glioblastoma

65 enrolled 30 charts

CNS

Brain Neoplasms, Glioblastoma

NCT01487265 2019-03-06

Trial of Erlotinib and BKM120 in Patients With Advanced Non Small Cell Lung Cancer Previously Sensitive to Erlotinib

37 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT01741753 2019-02-05

BKM120+Abiraterone Acetate for Metastatic CRPC

Phase 1 Terminated

4 enrolled

Neoplasm Metastasis, Prostatic Neoplasms

NCT02303041 2019-01-29

Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma

10 enrolled 11 charts

Dermatologic

Basal Cell Nevus Syndrome, Carcinoma, Basal Cell, Skin Neoplasms

NCT01790932 2019-01-23

BKM120 For Triple Negative Breast Cancer

50 enrolled 8 charts

Phase EARLY_PHASE1 Completed

Breast Neoplasms, Neoplasm Metastasis

NCT01719250 2018-10-09

Buparlisib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

7 enrolled

Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT02439489 2018-06-20

Study of the Combination of BKM120 and Cisplatin or Carboplatin in Patients With Advanced Solid Tumors

34 enrolled

Other solid neoplasm

Solid Tumors

NCT02404844 2018-04-20

PIKTAM

48 enrolled

Breast Neoplasms

NCT01470209 2018-03-19

A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies

43 enrolled

Lung Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT02194049 2018-01-09

Cisplatin, Etoposide and PI3K Inhibitor BKM120 in Treating Patients With Advanced Solid Tumors or Small Cell Lung Cancer

Other solid neoplasmThoracic

3 enrolled

Extensive Stage Small Cell Lung Cancer

NCT02487823 2017-11-17

NCMPC-BKM

Phase 1 Terminated

6 enrolled

Non Castrate Metastatic Prostate Cancer

NCT02301364 2017-10-19

Buparlisib (BKM120) In Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Recurrent/Refractory Secondary Central Nervous System Lymphoma (SCNSL)

4 enrolled 11 charts

Lymphoma, Recurrence

NCT01385293 2017-05-19

BKM120 in Metastatic Castration-resistant Prostate Cancer

30 enrolled 11 charts

Neoplasm Metastasis, Prostatic Neoplasms

NCT02452294 2017-05-03

BUMPER

Phase 2 Unknown

22 enrolled

Dermatologic

Melanoma, Neoplasm Metastasis

NCT01571024 2017-04-26

BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer

17 enrolled

Gastrointestinal

Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT01297452 2017-03-31

BKM120 + Carboplatin + Paclitaxel for Patients With Advanced Solid Tumors

45 enrolled

Other solid neoplasm

Solid Tumors

NCT01589861 2017-03-28

PIKHER2

Phase 1/2 Suspended

106 enrolled

Breast Neoplasms

NCT01339442 2017-01-25

BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancer

31 enrolled

Breast Neoplasms

NCT01304602 2017-01-06

A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer

20 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT01396499 2016-11-01

Study to Assess Safety, Tolerability and Preliminary Efficacy of BKM120, PI3K Kinase Inhibitor, With Advanced Leukemias

LymphoidOther hematologic neoplasm

16 enrolled

Leukemia, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01830504 2016-10-05

BKM120

Phase 2 Unknown

47 enrolled

Thyroid Neoplasms

NCT01723800 2016-09-20

PI3K Inhibitor BKM120, Carboplatin, and Pemetrexed Disodium in Treating Patients With Stage IV Non-Small Cell Lung Cancer

9 enrolled

Carcinoma, Non-Small-Cell Lung

NCT01248494 2016-07-25

PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast Cancer

72 enrolled

Breast Neoplasms

NCT02035124 2016-02-11

Cabazitaxel and BKM120 in Patients With Metastatic Castrate-Resistant Prostate Cancer (mCRPC) Previously Treated With Docetaxel

Tumor-Agnostic

Neoplasm Metastasis

NCT01501604 2015-09-17

BKM120 in Cancers With PIK3CA Activating Mutations

BreastGastrointestinalThoracic

Breast Neoplasms, Lung Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT01953445 2014-12-08

Paclitaxel and BKM120 Before Surgery in Treating Patients With Stage II or III Estrogen Receptor-Positive and HER2-Negative Breast Cancer

Breast Neoplasms

NCT01550380 2014-07-29

BKM120

Phase EARLY_PHASE1 Completed

Gynecologic

Endometrial Neoplasms

NCT01513356 2014-04-02

Pharmacodynamic Study of BKM120 in Breast Cancer

20 enrolled

Breast Neoplasms, Neoplasms

NCT01527877 2012-10-08

Study of BKM120 in Advanced Squamous Cell Carcinoma of Head and Neck

Phase 2 Unknown

53 enrolled