Clinical Trials

28 enrolled

Healthy Adult Participants

NCT05487235 2025-07-03

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

57 enrolled

Advanced Solid Tumors

NCT01585623 2025-03-05

Drug Interaction Study of SAR302503 in Patients With Solid Tumor

16 enrolled

Solid Tumor

NCT03864042 2024-09-27

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

56 enrolled 158 charts

Dermatologic

Melanoma

NCT02609386 2024-01-30

INSPIRE

Phase 2 Completed

105 enrolled 17 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT04718740 2023-08-14

A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer

33 enrolled

Gynecologic

Ovarian Neoplasms

NCT03531762 2023-07-28

Effect of a Proton Pump Inhibitor on the PK of Tepotinib

12 enrolled 16 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT03028103 2023-06-26

Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients

32 enrolled 30 charts

Lymphoid

Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT02740712 2023-06-09

DDI

17 enrolled

Neoplasms

NCT04676035 2023-02-09

The DDI Study Had Been Designed to Investigate the Effect of SHR3680 on the Pharmacokinetics of Midazolam, S-Warfarin and Omeprazole

18 enrolled

Genitourinary

Prostate Cancer Patients

NCT05438303 2023-01-12

Study to Assess the Effect of Co-Administration of AZD9833 on the Pharmacokinetics of Midazolam, of Omeprazole, of Celecoxib and of Dabigatran Etexilate in Healthy Postmenopausal Female Volunteers

59 enrolled

Breast

Breast Neoplasms

NCT04959266 2022-09-16

A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib

Phase 1 Terminated

5 enrolled

Advanced Solid Tumours

NCT04108676 2022-07-29

Effect of Omeprazole on PK of Fluzoparib in Healthy Male Subjects

16 enrolled

Advanced Solid Tumor

NCT01596647 2020-12-21

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

39 enrolled

Neoplasms

NCT00210470 2020-12-11

A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer

Phase 2 Completed

27 enrolled 16 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT00420615 2020-12-08

Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies

34 enrolled

Neoplasms

NCT01287598 2019-07-10

BAY73-4506 Probe Substrate Study

41 enrolled

Neoplasms

NCT02500641 2019-06-21

FORWARD

Phase 4 Completed

196 enrolled 9 charts

Arthritis, Cardiovascular Diseases, Gout, Inflammation, Hyperuricemia

NCT03333824 2019-03-25

Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer

33 enrolled

Solid Tumours

NCT01517399 2019-02-12

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

28 enrolled

Neoplasms

NCT01911728 2017-06-26

Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates

14 enrolled

Genitourinary

Pharmacokinetics of MDV3100

NCT01539655 2017-05-02

Vandetanib

34 enrolled

Carcinoma, Medullary

NCT02518373 2015-08-07

CC5

Phase 2 Completed

22 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT00442741 2012-04-25

Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)

Phase 1 Withdrawn

Neoplasms

NCT00942175 2012-02-03

A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.

160 enrolled 16 charts

Gastrointestinal

Esophagitis, Peptic, Stomach Ulcer, Zollinger-Ellison Syndrome

NCT00298779 2008-06-06

Open-Label Study to Assess the Effect of Omeprazole on the Pharmacokinetics of VELCADE in Patients With Either Advanced Solid Tumors or Non-Hodgkin's Lymphoma.

20 enrolled