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NCT02792582 2026-04-17

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

Phase 2 Active not recruiting

Brain Neoplasms, Craniopharyngioma

NCT01512589 2026-04-15

Proton Beam Therapy (PBT) Versus Intensity-Modulated Radiation Therapy (IMRT) Trial

Phase 2 Active not recruiting

Gastrointestinal

Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT03286335 2026-04-15

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Phase NA Recruiting

Brain Neoplasms

NCT07213934 2026-04-15

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

Phase 1/2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03323463 2026-04-13

Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07514819 2026-04-07

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

Phase NA Not yet recruiting

LymphoidSarcoma

Bone Neoplasms, Hodgkin Disease, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT03801876 2026-04-03

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Clinical Stage I Esophageal Adenocarcinoma AJCC v8

NCT03482791 2026-04-02

Proton Beam Therapy in the Treatment of Esophageal Cancer

Phase NA Active not recruiting

22 enrolled 29 charts

Gastrointestinal

Esophageal Neoplasms

NCT05655078 2026-03-30

HIT-Meso

Phase NA Recruiting

Other solid neoplasmThoracic

Mesothelioma, Malignant

NCT03164460 2026-03-20

Stereotactic Body Radiation Therapy or Intensity Modulated Radiation/Proton Therapy in Treating Patients With Recurrent Head and Neck Cancer

Phase 2 Suspended

Recurrent Head and Neck Carcinoma

NCT03281889 2026-03-19

Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation

Phase NA Active not recruiting

Brain Neoplasms

NCT04190446 2026-03-16

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Phase 2 Active not recruiting

Prostatic Neoplasms

NCT04219202 2026-03-10

Retro-Ion

Phase NA Recruiting

Sarcoma

NCT00496522 2026-03-09

Proton Beam Therapy for Chondrosarcoma

Phase 2 Active not recruiting

Chondrosarcoma

NCT01629498 2026-03-09

Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT07412314 2026-03-09

Proton Therapy for Recurrent Nasopharyngeal Carcinoma

Phase NA Recruiting

Nasopharyngeal Carcinoma

NCT04908709 2026-03-04

Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors

Phase NA Recruiting

Malignant Brain Glioma

NCT01893307 2026-02-24

Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

Phase 3 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT02125786 2026-02-24

A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

Phase 2 Active not recruiting

68 enrolled 11 charts

Ependymoma

NCT01946529 2026-02-23

Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

Phase 2 Active not recruiting

24 enrolled 11 charts

Neuroectodermal Tumors, Primitive, Peripheral, Desmoplastic Small Round Cell Tumor

NCT04278118 2026-02-17

HiPPI

Phase NA Recruiting

Brain Neoplasms, Meningioma, Neurilemmoma, Pituitary Neoplasms, Nerve Sheath Neoplasms

NCT04725903 2026-02-17

Proton Radiation Therapy for the Treatment of Patients With High Risk Prostate Cancer

Phase NA Recruiting

Prostatic Neoplasms

NCT05320406 2026-02-12

REVELUTION

Phase 2 Active not recruiting

94 enrolled 13 charts

Prostatic Neoplasms

NCT01049230 2026-02-11

Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors

Phase NA Active not recruiting

Neoplasms, Germ Cell and Embryonal

NCT03624660 2026-02-10

PR11

Phase 2 Active not recruiting

Prostatic Neoplasms

NCT06239272 2026-01-26

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Phase 1/2 Recruiting

Plasma cellSarcoma

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Glomus Tumor, Granuloma, Plasma Cell, Hemangiosarcoma, Liposarcoma, Myoepithelioma, Sarcoma, Osteosarcoma, Disorders of Sex Development, Granular Cell Tumor, Neoplasms, Adipose Tissue, Liposarcoma, Myxoid, Dermatofibrosarcoma, Sarcoma, Clear Cell, Smooth Muscle Tumor, Nerve Sheath Neoplasms, Neurofibrosarcoma, Hemangioendothelioma, Epithelioid, Vascular Neoplasms, Solitary Fibrous Tumors

NCT04968990 2026-01-23

Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

Phase 2 Recruiting

Wilms Tumor

NCT01617161 2026-01-22

PARTIQoL

Phase NA Active not recruiting

Prostatic Neoplasms

NCT04443413 2026-01-16

Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients

Phase 3 Active not recruiting

Anatomic Stage I Breast Cancer AJCC v8

NCT02179086 2026-01-14

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT03180268 2026-01-14

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Phase 3 Recruiting

Meningioma

NCT02112617 2025-12-30

Phase II Study of Proton Radiation Therapy for Neuroblastoma

Phase NA Recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT01950351 2025-12-22

Hypofractionated Proton Beam Therapy for Localized Prostate Cancer

Phase 1/2 Active not recruiting

Stage I Prostate Adenocarcinoma AJCC v7

NCT06200259 2025-12-18

Reduction of Gastrointestinal Toxicity in Prostate Cancer by Proton Spot Placement

Phase NA Recruiting

Prostatic Neoplasms

NCT01245712 2025-12-17

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

Phase 2 Active not recruiting

Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT01871766 2025-12-17

Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

Phase 2 Active not recruiting

Rhabdomyosarcoma

NCT00496119 2025-12-16

Proton Beam Therapy for Chordoma Patients

Phase 2 Active not recruiting

Chordoma

NCT01358058 2025-12-10

Proton Radiation Therapy for Gliomas

Phase NA Active not recruiting

Brain Neoplasms, Glioma

NCT01449149 2025-12-05

Proton Radiation for Chordomas and Chondrosarcomas

Phase NA Completed

54 enrolled 11 charts

Chondrosarcoma, Chordoma

NCT03132532 2025-11-25

Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

20 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT06008730 2025-11-10

Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Phase 2 Recruiting

Resectable Lung Non-Small Cell Carcinoma

NCT01419067 2025-10-20

A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection

Phase 2 Active not recruiting

Craniopharyngioma

NCT02444741 2025-10-09

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT06831461 2025-09-16

PRIDE

Phase NA Recruiting

Brain Neoplasms, Meningioma, Pituitary Neoplasms

NCT01063114 2025-08-13

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Phase NA Completed

90 enrolled 11 charts

Brain Neoplasms, Medulloblastoma, Pinealoma

NCT03180502 2025-07-11

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Phase 2 Active not recruiting

Astrocytoma, Glioma, Oligodendroglioma

NCT00592293 2025-07-03

Proton Radiation for the Treatment of Pediatric Bone and Non-Rhabdomyosarcoma Soft Tissue Sarcomas

Phase NA Completed

70 enrolled 9 charts

Bone Neoplasms, Sarcoma

NCT03778294 2025-07-03

18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy

Phase 2 Completed

43 enrolled 19 charts

Glioblastoma, Glioma

NCT00592592 2025-06-18

Proton Radiation Therapy (RT) for the Treatment of Pediatric Rhabdomyosarcoma

Phase NA Completed

115 enrolled 12 charts

Rhabdomyosarcoma

NCT01684904 2025-06-04

Proton Therapy for Esophageal Cancer

Phase NA Recruiting

Gastrointestinal

Esophageal Neoplasms