Clinical Trials

240 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT05586360 2026-03-04

T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer

36 enrolled

Genitourinary

Prostatic Neoplasms

NCT03400826 2025-07-14

Effects of Simvastatin on Uterine Leiomyoma Size

Phase 2 Not yet recruiting

60 enrolled

Leiomyoma

NCT07003815 2025-06-04

Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer

62 enrolled

Phase 2 Active not recruiting

Biliary Tract Neoplasms

NCT03324425 2025-02-27

SIMPHONY

5 enrolled

Breast Neoplasms

NCT05550415 2024-10-03

The Role of Simvastatin in the Epithelial-Mesenchymal Transition Process of Breast Cancer

26 enrolled

Triple Negative Breast Neoplasms

NCT02096588 2024-07-09

Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin

Phase 2 Terminated

34 enrolled 11 charts

Breast Neoplasms

NCT03454529 2023-08-01

The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer

24 enrolled 13 charts

Breast Neoplasms

NCT04985201 2021-08-09

Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

40 enrolled

Thoracic

Small Cell Lung Carcinoma

NCT04698941 2021-07-29

Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

40 enrolled

Thoracic

Small Cell Lung Carcinoma

NCT04418089 2020-06-05

Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer

60 enrolled

Margins of Excision, Breast Neoplasms

NCT02161822 2020-03-25

Capecitabine Plus Simvastatin in Locally Advanced Rectal Cancer Patients

60 enrolled

Rectal Neoplasms

NCT00334542 2019-04-03

Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer

50 enrolled 6 charts

Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT02026583 2018-01-17

A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients

43 enrolled

Colorectal Neoplasms

NCT01332617 2017-12-29

Phase II Study of Simvastatin for Relapsed/Refractory Myeloma

Phase 2 Withdrawn

Plasma cell

Multiple Myeloma, Neoplasms, Plasma Cell

NCT00944463 2017-02-17

Trial of Simvastatin and Gemcitabine in Pancreatic Cancer Patients

106 enrolled

Pancreatic Neoplasms

NCT02360618 2016-07-11

Metformin and Simvastatin Use in Bladder Cancer

44 enrolled

Genitourinary

Urinary Bladder Neoplasms

NCT02104193 2016-02-17

Simvastatin Effect on Radiation Therapy of Brain Metastases

50 enrolled

CNS

Brain Neoplasms

NCT00575965 2015-12-16

Simvastatin in Waldenstrom's Macroglobulinemia

Phase 2 Terminated

18 enrolled 5 charts

Lymphoid

Waldenstrom Macroglobulinemia

NCT01561482 2015-07-22

Study of Metformin With Simvastatin for Men With Prostate Carcinoma

Phase 2 Withdrawn

Genitourinary

Prostatic Neoplasms

NCT00503763 2015-04-16

PSMMSS

Phase 2 Withdrawn

Plasma cell

Smoldering Multiple Myeloma

NCT01500577 2014-06-18

A Prevention Trial in Subjects at High Risk for Breast Cancer

150 enrolled

Breast Neoplasms

NCT00807950 2014-01-22

Phase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast Cancer

100 enrolled

Breast Neoplasms

NCT00354640 2013-06-24

Simvastatin and Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ or Invasive Breast Cancer

11 enrolled 5 charts

Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT00313859 2012-02-02

Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC

50 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT00399867 2006-12-20

Simvastatin as Inhibitor of Cell Adhesion Mediated Drug Resistance in Patients With Refractory Multiple Myeloma.