Clinical Trials Browser

Phase 2 × Terminated × Sirolimus × Clear all

NCT03246906 2026-05-14

Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation

Phase 2 Terminated

150 enrolled 18 charts

LymphoidMyeloidOther hematologic neoplasmPlasma cell

Blastic Plasmacytoid Dendritic Cell Neoplasm, Hematologic Diseases, Hodgkin Disease, Waldenstrom Macroglobulinemia, Multiple Myeloma, Myelodysplastic Syndromes, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Prolymphocytic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases

NCT03363763 2025-12-01

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Phase 2 Terminated

24 enrolled 11 charts

Erythema, Exanthema, Fibroma, Tuberous Sclerosis, Facies

NCT03456700 2025-05-08

Auranofin and Sirolimus in Treating Participants With Ovarian Cancer

Phase 2 Terminated

22 enrolled 9 charts

Ovarian Neoplasms

NCT04393454 2024-07-25

Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy

Phase 2 Terminated

6 enrolled 12 charts

Neoplasm Metastasis, Neoplasms

NCT02642094 2023-12-05

Aging Mammary Stem Cells and Breast Cancer Prevention

Phase 2 Terminated

58 enrolled 11 charts

Breast Neoplasms

NCT02110069 2023-09-21

A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors

Phase 2 Terminated

4 enrolled 8 charts

Tufted angioma, Kaposiform Hemangioendothelioma, Hemangioendothelioma, Vascular Malformations, Kasabach-Merritt Syndrome

NCT00506948 2020-09-24

Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute Graft-Versus-Host Disease (GVHD)

Phase 2 Terminated

13 enrolled 5 charts

LymphoidMyeloidOther hematologic neoplasm

Graft vs Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Hematologic Neoplasms

NCT01856101 2019-04-10

BEZ235

Phase 2 Terminated

Carcinoma, Transitional Cell

NCT01116232 2019-03-26

Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation

Phase 2 Terminated

4 enrolled 4 charts

DermatologicLymphoidMyeloidOther hematologic neoplasmPlasma cell

Pdgfra-Associated Chronic Eosinophilic Leukemia, Congenital Abnormalities, Blast Crisis, Burkitt Lymphoma, Graft vs Host Disease, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Leukemia, Hairy Cell, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Myelodysplastic Syndromes, Myeloproliferative Disorders, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Prolymphocytic, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms, Plasma Cell, Lymphoma, Extranodal NK-T-Cell, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis, Intraocular Lymphoma

NCT01962896 2019-02-26

A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell Tumors

Phase 2 Terminated

4 enrolled 6 charts

Neoplasms, Germ Cell and Embryonal

NCT00276744 2018-10-24

Individualized Drug Treatment for Treating Patients With Pancreatic Cancer

Phase 2 Terminated

249 enrolled 4 charts

Gastrointestinal

Pancreatic Neoplasms

NCT01220297 2017-06-05

Sirolimus & Mycophenolate Mofetil as GvHD Prophylaxis in Myeloablative, Matched Related Donor HCT

Phase 2 Terminated

3 enrolled 13 charts

LymphoidOther hematologic neoplasm

Hematologic Diseases, Hodgkin Disease, Leukemia, Lymphoma, Non-Hodgkin

NCT01534143 2017-04-05

High Dose Busulfan and Bortezomib in Treating Patients With High Risk Multiple Myeloma Undergoing Stem Cell Transplant

Phase 2 Terminated

1 enrolled 6 charts

Multiple Myeloma

NCT01061606 2016-11-09

Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus

Phase 2 Terminated

8 enrolled 6 charts

GynecologicSarcoma

Recurrent Uterine Sarcoma

NCT01842594 2015-11-03

A Phase II Trial of Combined Hydroxychloroquine and Sirolimus in Soft Tissue Sarcoma

Phase 2 Terminated

13 enrolled 4 charts

Sarcoma

NCT01488253 2015-04-03

Sirolimus/Tacrolimus Combination After HLA Matched Related Peripheral Blood Stem Cell Transplants

Phase 2 Terminated

MyeloidOther hematologic neoplasm

Graft vs Host Disease, Myelodysplastic Syndromes, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase

NCT01166126 2014-05-15

Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV

Phase 2 Terminated

4 enrolled 7 charts

Melanoma

NCT00086840 2013-01-24

CCI-779 in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Phase 2 Terminated

LymphoidOther hematologic neoplasm

Hodgkin Disease, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse