Clinical Trials Browser

Phase 2 × NIH × Temozolomide × Clear all

NCT03581292 2026-05-27

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Phase 2 Active not recruiting

38 enrolled 13 charts

Astrocytoma, Glioblastoma, Glioma

NCT04394858 2026-05-13

Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer

Phase 2 Active not recruiting

Paraganglioma, Pheochromocytoma

NCT01638546 2026-04-29

Temozolomide With or Without Veliparib in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer

Phase 2 Active not recruiting

97 enrolled 12 charts

Small Cell Lung Carcinoma

NCT05142241 2025-11-18

Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trial

Phase 2 Active not recruiting

Paraganglioma, Pheochromocytoma

NCT03018288 2025-08-08

Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)

Phase 2 Terminated

90 enrolled 24 charts

Glioblastoma, Glioma

NCT01827384 2023-09-29

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

Phase 2 Completed

208 enrolled 27 charts

Other solid neoplasm

Advanced Malignant Solid Neoplasm

NCT01767194 2022-10-24

Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma

Phase 2 Completed

73 enrolled 12 charts

Neuroblastoma, Ganglioneuroblastoma

NCT01835145 2022-08-04

Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by Surgery

Phase 2 Completed

47 enrolled 12 charts

Uveal Melanoma

NCT01062425 2022-07-26

Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Completed

261 enrolled 10 charts

Glioblastoma, Gliosarcoma

NCT00275002 2022-02-11

O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors

Phase 2 Completed

41 enrolled 9 charts

Central Nervous System Neoplasms

NCT01217437 2021-07-23

Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors

Phase 2 Completed

108 enrolled 14 charts

Medulloblastoma, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive

NCT00826241 2019-03-22

Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma

Phase 2 Completed

58 enrolled 11 charts

Brain Neoplasms, Ependymoma, Spinal Cord Neoplasms

NCT00433381 2018-09-17

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

Phase 2 Completed

123 enrolled 16 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01055314 2017-08-29

Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

Phase 2 Completed

175 enrolled 13 charts

Rhabdomyosarcoma, Sarcoma

NCT01143402 2017-07-26

Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye

Phase 2 Completed

120 enrolled 8 charts

Uveal Melanoma

NCT00436436 2017-03-28

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Phase 2 Terminated

12 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00302159 2016-08-18

Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors

Phase 2 Completed

43 enrolled 14 charts

Brain Neoplasms, Glioblastoma

NCT00492687 2014-01-10

Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas

Phase 2 Unknown

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003718 2014-01-06

Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma

Phase 2 Unknown

GynecologicSarcoma

Malignant mesenchymal tumor, Hemangiopericytoma, Malignant, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Ovarian Neoplasms, Rhabdomyosarcoma, Sarcoma, Sarcoma, Synovial, Endometrial Neoplasms, Sarcoma, Endometrial Stromal, Sarcoma, Alveolar Soft Part, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT00004204 2014-01-06

Temozolomide in Treating Patients With Recurrent or Progressive Malignant Glioma

Phase 2 Unknown

Astrocytoma, Brain Neoplasms, Oligodendroglioma, Central Nervous System Neoplasms

NCT00033709 2014-01-06

Temozolomide and Thalidomide in Treating Patients With Metastatic, Locally Advanced, or Unresectable Leiomyosarcoma

Phase 2 Unknown

Leiomyosarcoma, Sarcoma

NCT00005054 2013-09-20

Temozolomide in Treating Women With Advanced Breast Cancer

Phase 2 Unknown

Breast Neoplasms

NCT00276679 2013-09-17

Temozolomide in Treating Young Patients With High-Risk Relapsed or Refractory Neuroblastoma

Phase 2 Completed

Neuroblastoma

NCT00360945 2013-09-17

Cisplatin and Temozolomide in Treating Young Patients With Malignant Glioma

Phase 2 Unknown

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms

NCT01217398 2013-08-26

Temozolomide and Bevacizumab in Treating Patients With Metastatic Melanoma of the Eye

Phase 2 Unknown

Uveal Melanoma

NCT00514397 2013-08-12

Temozolomide and Radiation Therapy in Treating Young Patients With Pontine Glioma

Phase 2 Unknown

Central Nervous System Neoplasms

NCT00039494 2013-08-02

Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors

Phase 2 Completed

Glioblastoma, Gliosarcoma

NCT00014092 2013-03-26

Chemotherapy Followed by Biological Therapy in Treating Patients With Stage IV Melanoma That Cannot be Treated With Surgery

Phase 2 Completed

Melanoma

NCT00072163 2013-01-17

Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma

Phase 2 Completed

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00875355 2009-08-26

Radiation Therapy With or Without Temozolomide in Treating Women With Brain Metastases and Breast Cancer

Phase 2 Unknown

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis