Clinical Trials Browser

Phase 2 × Valproic Acid × Clear all

NCT05694936 2026-05-08

Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05821556 2026-04-14

Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients

Phase 2 Recruiting

Neoplasm Metastasis

NCT02068586 2026-03-16

Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma

Phase 2 Active not recruiting

Uveal Melanoma

NCT06714357 2025-12-17

VICTORIA

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT03357757 2025-06-26

LATENT

Phase 2 Completed

GastrointestinalLymphoid

Cancer That is Associated With a Chronic Viral Infection

NCT01817751 2024-07-17

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Phase 2 Completed

47 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Glioma, Neurologic Manifestations

NCT02624128 2023-11-13

V-CHANCE

Phase 2 Unknown

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT04310176 2023-11-13

REVOLUTION

Phase 2 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT00879437 2021-07-21

Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma

Phase 2 Completed

38 enrolled 53 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neuroepithelial, Gliosarcoma

NCT02124174 2021-04-26

Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDS

Phase 2 Unknown

Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01900730 2020-02-25

Study of Valproic Acid (VPA) vs Placebo to Shorten Time of Indwelling Pleural Catheter

Phase 2 Terminated

3 enrolled 6 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00414310 2019-05-21

Decitabine (DAC) w/ or w/o Valproic Acid (VPA) in Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)

Phase 2 Completed

153 enrolled 8 charts

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00670046 2018-09-28

Valproic Acid in Treating Patients With Progressive, Non-Metastatic Prostate Cancer

Phase 2 Terminated

15 enrolled 11 charts

Prostatic Neoplasms

NCT01182285 2018-05-16

A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin

Phase 2 Completed

13 enrolled 11 charts

Thyroid Neoplasms

NCT00867672 2016-08-31

DECIDER

Phase 2 Completed

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT00302159 2016-08-18

Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors

Phase 2 Completed

43 enrolled 14 charts

Brain Neoplasms, Glioblastoma

NCT01695122 2016-02-23

Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00634205 2015-02-12

Phase II Study of Valproate and Doxorubicin in Malignant Mesothelioma

Phase 2 Completed

Other solid neoplasmThoracic

Mesothelioma, Malignant, Mesothelioma

NCT00759824 2015-02-12

A Phase II Study of Doxorubicin, Cyclophosphamide and Vindesine With Valproic Acid in Patients With Refractory or Relapsing Small Cell Lung Cancer After Platinum Derivatives and Etoposide

Phase 2 Completed

Small Cell Lung Carcinoma

NCT00525135 2015-02-03

Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer

Phase 2 Terminated

5 enrolled 2 charts

Head and Neck Neoplasms

NCT01016990 2014-01-10

Valproic Acid in Treating Patients With Previously Treated Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Chronic Lymphocytic Leukemia

Phase 2 Unknown

DermatologicLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00382590 2012-08-07

Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients

Phase 2 Completed

11 enrolled 6 charts

MyeloidOther hematologic neoplasm

Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00326170 2012-06-15

Phase II 5-Azacytidine Plus VPA Plus ATRA

Phase 2 Completed

34 enrolled 5 charts

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01011998 2011-09-27

A Study of Imatinib and Valproic Acid in Patients With Chronic Myelogenous Leukemia (CML)

Phase 2 Withdrawn

MyeloidOther hematologic neoplasm

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

NCT00524667 2011-07-20

HDAC Inhibitor Valproic Acid as an Effective Therapy for Chronic Lymphocytic Leukemia

Phase 2 Terminated

LymphoidOther hematologic neoplasm

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01333631 2011-04-12

Valproic Acid With Chemoradiotherapy for Pancreatic Cancer

Phase 2 Unknown

Gastrointestinal

Pancreatic Neoplasms

NCT00404326 2006-11-28

Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer

Phase 2 Completed

Uterine Cervical Neoplasms

NCT00404508 2006-11-28

A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors

Phase 2 Completed

Other solid neoplasm

Refractory Solid Tumors