Clinical Trials

47 enrolled 13 charts

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Glioblastoma, Glioma, Neurologic Manifestations

NCT01738815 2021-10-22

Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder Cancer

43 enrolled

Genitourinary

Urinary Bladder Neoplasms, Hematuria

NCT00879437 2021-07-21

Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma

38 enrolled 53 charts

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neuroepithelial, Gliosarcoma

NCT03885947 2021-05-24

VPA Expanded UCB Transplantation for Treatment of Patients With Hematological Malignancies

LymphoidMyeloidOther hematologic neoplasm

7 enrolled

Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Hematologic Neoplasms

NCT02520115 2019-08-14

Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer

50 enrolled

Gynecologic

Ovarian Neoplasms

NCT00414310 2019-05-21

Decitabine (DAC) w/ or w/o Valproic Acid (VPA) in Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)

153 enrolled 8 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00075010 2018-11-15

Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes

54 enrolled

Leukemia, Myelodysplastic Syndromes

NCT01106872 2018-08-10

Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas

47 enrolled

Sarcoma

NCT01182285 2018-05-16

A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin

13 enrolled 11 charts

Head & Neck

Thyroid Neoplasms

NCT01622439 2018-03-12

VALFRID

Phase EARLY_PHASE1 Completed

50 enrolled

Lymphoid

Lymphoma, Lymphoma, Large B-Cell, Diffuse

NCT02608736 2018-02-01

GAMA

42 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02144623 2017-03-03

PREVAIL

Phase EARLY_PHASE1 Completed

4 enrolled

LymphoidOther hematologic neoplasm

Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell

NCT00246103 2017-02-23

Phase I Trial of Valproic Acid and Epirubicin in Solid Tumor Malignancies

82 enrolled

Tumor-Agnostic

Neoplasms

NCT00867672 2016-08-31

DECIDER

Other hematologic neoplasm

204 enrolled

Leukemia, Myeloid, Acute

NCT00302159 2016-08-18

Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors

43 enrolled 14 charts

Brain Neoplasms, Glioblastoma

NCT01695122 2016-02-23

Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

14 enrolled

Head & Neck

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00996060 2016-01-18

Use of Hydralazine and Valproic Acid in Advanced Solid Tumor Malignancies

29 enrolled

Thoracic

Lung Neoplasms

NCT00175812 2015-06-24

Differentiation Induction in Acute Myelogenous Leukemia

Other hematologic neoplasm

24 enrolled

Leukemia, Myeloid, Acute

NCT00995332 2015-06-24

Disease Stabilization in AML by Treatment With ATRA, Valproic Acid and Low-dose Cytarabine

Other hematologic neoplasm

36 enrolled

Leukemia, Myeloid, Acute

NCT00634205 2015-02-12

Phase II Study of Valproate and Doxorubicin in Malignant Mesothelioma

Other solid neoplasmThoracic

45 enrolled

Mesothelioma, Malignant, Mesothelioma

NCT00759824 2015-02-12

A Phase II Study of Doxorubicin, Cyclophosphamide and Vindesine With Valproic Acid in Patients With Refractory or Relapsing Small Cell Lung Cancer After Platinum Derivatives and Etoposide

64 enrolled

Thoracic

Small Cell Lung Carcinoma

NCT00530907 2015-01-08

Valproic Acid and Bevacizumab in Patients With Advanced Cancer

71 enrolled

Advanced Cancer

NCT00075777 2014-08-29

Valproic Acid in Treating Patients With Kaposi's Sarcoma

Phase NA Completed

19 enrolled

Sarcoma

AIDS-related Kaposi sarcoma, Sarcoma, Sarcoma, Kaposi

NCT00107458 2014-08-07

Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors

26 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT00079378 2013-09-30

Decitabine and Valproic Acid in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

LymphoidOther hematologic neoplasm

84 enrolled

Congenital Abnormalities, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT00084981 2013-09-30

Decitabine and Valproic Acid in Treating Patients With Non-Small Cell Lung Cancer

25 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT00109824 2013-06-04

Decitabine With or Without Valproic Acid in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

42 enrolled

Lymphoid

Burkitt Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT00529022 2013-02-20

Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer

36 enrolled

Gynecologic

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00495872 2012-10-18

Valproic Acid-Based 2-Agent Oral Regimens for Patients With Advanced Solid Tumor

204 enrolled

Other solid neoplasm

Solid Tumors

NCT00513162 2012-09-19

Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases

8 enrolled

Brain Neoplasms, Neuroectodermal Tumors

NCT00382590 2012-08-07

Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients

11 enrolled 6 charts

Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00496444 2012-08-01

Azacytidine and Valproic Acid in Patients With Advanced Cancers

69 enrolled

Advanced Cancers

NCT00326170 2012-06-15

Phase II 5-Azacytidine Plus VPA Plus ATRA

34 enrolled 5 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00404326 2006-11-28

Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer

18 enrolled

Gynecologic

Uterine Cervical Neoplasms

NCT00404508 2006-11-28

A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors