Clinical Trials Browser

Interventional × Vitamin B 12 × Clear all

NCT04150042 2026-01-29

SHARON

Phase 1 Recruiting

BreastGastrointestinal

Breast Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Recurrence

NCT06285357 2025-11-20

The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.

Phase NA Recruiting

Papillomavirus Infections

NCT05096663 2025-05-15

Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Phase 2/3 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05289908 2025-05-04

Intrathecal Pemetrexed for Leptomeningeal Metastasis

Phase 1/2 Completed

Meningeal Carcinomatosis

NCT04786964 2025-04-02

CONTERNO

Phase 3 Terminated

25 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT06661083 2025-03-19

The Effect of Natural Molecules on HPV Infection

Phase NA Completed

Papillomavirus Infections

NCT02578680 2024-09-20

MK-3475-189

Phase 3 Completed

616 enrolled 19 charts 2 FDA

Carcinoma, Non-Small-Cell Lung

NCT04205786 2024-08-21

Vitamin B12 for Aromatase Inhibitors Associated Musculoskeletal Symptoms in Breast Cancer

Phase NA Withdrawn

HR-positive Breast Cancer

NCT03950674 2024-06-10

MK-3475-189

Phase 3 Completed

40 enrolled 20 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung

NCT05625308 2022-12-22

Effect of Natural Compounds on the Severity of HPV-induced Cervical Lesions

Phase NA Completed

Papilloma

NCT04265534 2022-09-21

KEAPSAKE

Phase 2 Terminated

Carcinoma, Non-Small-Cell Lung

NCT05505006 2022-08-19

Management of Preoperative Anaemia in Surgical Oncology

Phase 4 Unknown

Classical hematology

Anemia, Neoplasms

NCT03626922 2022-06-10

Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients

Phase 1 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT00402883 2021-11-09

Chemotherapy, Radiotherapy and Bevacizumab in Patients With Unresectable Stage III Non-Small-Cell Lung Cancer

Phase 2 Terminated

5 enrolled 6 charts

Lung Neoplasms

NCT00998946 2021-11-05

Study of Pralatrexate to Treat Participants With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma

Phase 2 Completed

29 enrolled 8 charts

Recurrence, Lymphoma, B-Cell

NCT00606502 2021-03-05

Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment

Phase 2 Completed

201 enrolled 12 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Smoking

NCT03593304 2020-07-08

Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients

Phase 2/3 Completed

LymphoidOther hematologic neoplasm

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00481871 2020-01-07

Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies

Phase 1/2 Completed

119 enrolled 13 charts

LymphoidOther hematologic neoplasm

Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Recurrence, Lymphoma, B-Cell, Lymphoma, T-Cell, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, Extranodal NK-T-Cell

NCT01118624 2020-01-07

Study of Pralatrexate in Female Patients With Previously-treated Breast Cancer

Phase 2 Completed

22 enrolled 10 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00554827 2020-01-03

Study of Pralatrexate in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma

Phase 1 Completed

DermatologicLymphoid

Lymphoma, Mycosis Fungoides, Recurrence, Sezary Syndrome, Lymphoma, T-Cell, Lymphoma, T-Cell, Cutaneous

NCT01134341 2019-12-18

Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma

Phase 1 Completed

DermatologicLymphoid

Mycosis Fungoides, Recurrence, Sezary Syndrome, Lymphoma, T-Cell, Cutaneous, Lymphoma, Primary Cutaneous Anaplastic Large Cell

NCT00722553 2019-12-17

Study of Pralatrexate to Treat Advanced or Metastatic Relapsed Transitional Cell Carcinoma of the Urinary Bladder

Phase 2 Completed

30 enrolled 12 charts

Urinary Bladder Neoplasms, Carcinoma, Carcinoma, Transitional Cell, Neoplasm Metastasis, Recurrence

NCT00923273 2019-11-26

Sirolimus and Pemetrexed to Treat Non-Small Cell Lung Cancer

Phase 1/2 Terminated

42 enrolled 16 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02106650 2019-11-20

Phase II Study of Folotyn With Leucovorin to Prevent/Reduce Mucositis in Patients With Hematological Malignancies

Phase 2 Completed

Lymphoma, T-Cell, Peripheral

NCT03349333 2019-10-01

A Single Arm Study Evaluating the Efficacy and Safety of Pralatrexate in Subjects With Relapsed or Refractory PTCL

Phase 3 Completed

85 enrolled 26 charts

Lymphoma, T-Cell, Lymphoma, T-Cell, Peripheral

NCT01165021 2019-09-25

A Study of Pemetrexed/Cisplatin as Pre-operative Treatment of Early Stage Nonsquamous Non-Small Cell Lung Cancer

Phase 2 Completed

19 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung

NCT02795572 2019-07-05

CIPN

Phase 2 Terminated

Breast Neoplasms, Peripheral Nervous System Diseases

NCT00243022 2019-04-30

Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme

Phase 2 Terminated

12 enrolled 15 charts

Astrocytoma, Brain Edema, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT03903952 2019-04-05

Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?

Phase NA Completed

Atypical Squamous Cells of the Cervix

NCT03101579 2019-03-19

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Phase 1 Completed

Recurrence, Meningeal Carcinomatosis

NCT03778008 2018-12-27

Recombinant Bovine Basic Fibroblast Growth Factor for the Treatment of Radiation Induced Oral Mucositis

Phase 2 Unknown

Nasopharyngeal Carcinoma, Stomatitis

NCT03069313 2018-02-01

Vitamin B12 for Aromatase Inhibitors Musculoskeletal Symptoms

Phase NA Completed

41 enrolled 8 charts

Breast Neoplasms, Arthralgia

NCT01188876 2018-01-19

Carboplatin/Pralatrexate in Recurrent Platinum-Sensitive Ovarian, Fallopian or Primary Peritoneal Cancer

Phase 1/2 Completed

50 enrolled 15 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms, Recurrence

NCT02013362 2017-11-09

Phase I/II Clinical Study of Pralatrexate in Japanese Patients With Relapsed or Refractory Peripheral T-cell Lymphoma

Phase 1/2 Completed

Lymphoma, T-Cell, Peripheral

NCT03193788 2017-06-21

PREMIER

Phase 3 Unknown

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Ureteral Neoplasms

NCT02679443 2017-04-25

PEMVITASTART

Phase NA Completed

Classical hematologyThoracic

Adenocarcinoma of Lung, Cytopenia, Anemia, Neutropenia, Thrombocytopenia

NCT00227019 2017-03-06

Phase 2 Trial of Bevacizumab in Combination With Pemetrexed

Phase 2 Completed

16 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00806819 2017-02-02

Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC

Phase 3 Completed

718 enrolled 21 charts

Carcinoma, Non-Small-Cell Lung

NCT00216099 2016-07-29

Pemetrexed as Second-Line Therapy in Treating Patients With Hormone Refractory Prostate Cancer

Phase 2 Completed

49 enrolled 15 charts

Prostatic Neoplasms

NCT01194453 2016-06-16

AP/GP

Phase 2 Completed

288 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung

NCT02735317 2016-04-12

Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT

Phase 2 Unknown

Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms, Stomatitis

NCT00659269 2016-02-26

A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients

Phase 3 Completed

319 enrolled 7 charts

Neoplasms, Neuralgia

NCT01183065 2015-11-20

Study of Pralatrexate With Vitamin B12 and Folic Acid Supplementation for Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Cancer (HNSCC)

Phase 2 Completed

13 enrolled 6 charts

Head and Neck Neoplasms

NCT01057589 2013-09-18

A Study for Patients With Recurrent or Metastatic Squamous Cell Head and Neck Cancer

Phase 2 Completed

66 enrolled 11 charts

Head and Neck Neoplasms, Laryngeal Diseases, Thyroid Diseases

NCT01569919 2013-03-12

SKOPOS

Phase 2 Unknown

Other solid neoplasmThoracic

Mesothelioma

NCT00699478 2012-07-19

Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy

Phase 2 Completed

Gastrointestinal

Stomach Neoplasms, Vitamin B 12 Deficiency

NCT00541073 2011-05-17

Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery

Phase 2 Completed

Other solid neoplasmThoracic

Mesothelioma, Malignant

NCT00609518 2010-12-28

A Study for Patients With Non-Squamous Non-Small Cell Lung Cancer

Phase 2 Completed

111 enrolled 17 charts

Carcinoma, Non-Small-Cell Lung

NCT00106886 2005-09-20

HOPE-2 Study (Heart Outcomes Prevention Evaluation-2 Study)

Phase 4 Unknown

Cardiovascular Diseases, Myocardial Infarction, Neoplasms, Stroke