Clinical Trials Browser

Phase 1 × Completed × adavosertib × Clear all

NCT02617277 2026-03-04

Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours

Phase 1 Completed

Other solid neoplasm

Advanced Solid Tumours

NCT01849146 2025-01-09

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

Phase 1 Completed

Glioblastoma

NCT03028766 2024-09-19

WISTERIA

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms

NCT01922076 2024-01-31

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Phase 1 Completed

46 enrolled 20 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Gliosarcoma

NCT00648648 2023-09-21

MK-1775-001

Phase 1 Completed

206 enrolled 40 charts

Other solid neoplasm

Solid Tumors

NCT02482311 2023-07-03

Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours

Phase 1 Completed

BreastGynecologicThoracic

Ovarian Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT02610075 2023-07-03

Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.

Phase 1 Completed

Ovarian Neoplasms

NCT04462952 2022-07-25

Study of Adavosertib(AZD1775) in Japanese Patients With Advanced Solid Tumours

Phase 1 Completed

Other solid neoplasm

Advanced Solid Tumours

NCT01748825 2021-07-26

AZD1775 for Advanced Solid Tumors

Phase 1 Completed

67 enrolled 24 charts

Other solid neoplasm

Solid Tumors

NCT02585973 2021-06-29

Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT02906059 2020-10-12

Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer

Phase 1 Completed

Gastrointestinal

Colorectal Neoplasms

NCT02511795 2019-11-07

AZD1775 Combined With Olaparib in Patients With Refractory Solid Tumors

Phase 1 Completed

Small Cell Lung Carcinoma

NCT02341456 2019-03-25

Phase Ib Study AZD1775 in Combination With Carboplatin and Paclitaxel in Adult Asian Patients With Solid Tumours

Phase 1 Completed

19 enrolled 53 charts

Other solid neoplasm

Advanced Solid Tumours

NCT02508246 2019-03-13

WEE1 Inhibitor MK-1775, Docetaxel, and Cisplatin Before Surgery in Treating Patients With Borderline Resectable Stage III-IVB Squamous Cell Carcinoma of the Head and Neck

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck