Clinical Trials Browser

Advanced Solid Tumours

Lung Neoplasms

Glioblastoma

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms

Platinum Refractory Extensive-Stage Small Cell Lung Carcinoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Gliosarcoma

Advanced Malignant Solid Neoplasm

Ovarian, Fallopian Tube, Peritoneal Cancer, P53 Mutation

Advanced Malignant Solid Neoplasm

Medulloblastoma, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive

Solid Tumors

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Ovarian Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

Ovarian Neoplasms

Metastatic Pancreatic Adenocarcinoma

Advanced Solid Tumours

Triple-negative Metastatic Breast Cancer

Solid Tumors

Squamous Cell Carcinoma of Head and Neck

Small Cell Lung Carcinoma

Glioblastoma

Colorectal Neoplasms

Small Cell Lung Carcinoma

Chromosome 5q Deletion Syndrome, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Myelodysplastic-Myeloproliferative Diseases

Advanced Solid Tumours

Squamous Cell Carcinoma of Head and Neck

Clinical Trials

Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours

AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

WISTERIA

A Phase II, Study to Determine the Preliminary Efficacy of Novel Combinations of Treatment in Patients With Platinum Refractory Extensive-Stage Small-Cell Lung Cancer

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification

Adavosertib Plus Chemotherapy in Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors

MK-1775-001

A Study of Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

M10MKO

Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours

Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride With or Without WEE1 Inhibitor AZD1775 in Treating Patients With Previously Untreated Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery

Study of Adavosertib(AZD1775) in Japanese Patients With Advanced Solid Tumours

CISPLATIN + AZD-1775 In Breast Cancer

AZD1775 for Advanced Solid Tumors

Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients

A Phase 0 Study of AZD1775 in Recurrent GBM Patients

Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer

AZD1775 Combined With Olaparib in Patients With Refractory Solid Tumors

WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome

Phase Ib Study AZD1775 in Combination With Carboplatin and Paclitaxel in Adult Asian Patients With Solid Tumours

WEE1 Inhibitor MK-1775, Docetaxel, and Cisplatin Before Surgery in Treating Patients With Borderline Resectable Stage III-IVB Squamous Cell Carcinoma of the Head and Neck