Clinical Trials Browser

Completed × Interventional × aflibercept × Clear all

NCT02159989 2025-10-20

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Phase 1 Completed

83 enrolled 21 charts

GastrointestinalGynecologic

Fibrolamellar hepatocellular carcinoma, Adenoma, Islet Cell, Neoplasm Metastasis, Ovarian Neoplasms

NCT00532155 2025-09-10

VITAL

Phase 3 Completed

913 enrolled 16 charts

Carcinoma, Lung Neoplasms

NCT03186326 2025-06-29

SAMCO

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT03172299 2025-03-24

PROTECT

Phase 3 Completed

Uveal Melanoma

NCT01652196 2025-02-05

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

Phase 2 Completed

56 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02384759 2024-07-10

FOLFA

Phase 2 Completed

117 enrolled 12 charts

Gastrointestinal

Colorectal Neoplasms

NCT00407654 2024-03-04

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

Phase 2 Completed

75 enrolled 15 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03530267 2024-02-23

ELDERLY

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01782443 2023-08-14

Ziv-Aflibercept for Advanced Progressive Carcinoid Tumors

Phase 2 Completed

19 enrolled 11 charts

Carcinoid Tumor, Neoplasm Metastasis

NCT03279289 2023-04-13

AFEMA

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT03043729 2023-02-06

mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT02181556 2021-06-07

Efficacy and Safety of Aflibercept in Combination With FOLFIRI Chemotherapy as 1st Line Treatment for Patients With Metastatic Colorectal Cancer

Phase 2 Completed

41 enrolled 8 charts

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT02340949 2021-05-03

RIA

Phase 2 Completed

180 enrolled 15 charts

Gastrointestinal

Rectal Neoplasms

NCT02101918 2020-03-23

Ziv-Aflibercept in Treating and Computed Tomography Perfusion Imaging in Predicting Response in Patients With Pancreatic Neuroendocrine Tumors That Are Metastatic or Cannot Be Removed by Surgery

Phase 2 Completed

22 enrolled 10 charts

Somatostatinoma, Multiple Endocrine Neoplasia Type 1

NCT01747551 2020-02-10

FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer

Phase 2 Completed

64 enrolled 11 charts

Gastrointestinal

Esophageal Neoplasms, Stomach Neoplasms

NCT00462826 2019-07-23

VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer

Phase 2 Completed

49 enrolled 13 charts

Endometrial Neoplasms

NCT01258855 2019-05-10

Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Phase 2 Completed

84 enrolled 13 charts

Melanoma

NCT00436501 2019-02-26

VEGF Trap and Docetaxel in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Phase 1/2 Completed

58 enrolled 16 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

NCT01661972 2018-10-29

X-TRAP

Phase 1/2 Completed

63 enrolled 12 charts

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT00450255 2018-05-24

VEGF Trap in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Phase 2 Completed

41 enrolled 7 charts

Uveal Melanoma, Melanoma

NCT01571284 2018-04-17

Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen

Phase 3 Completed

781 enrolled 28 charts

Gastrointestinal

Colorectal Cancer Metastatic

NCT01843725 2018-01-31

MOMENTUM1

Phase 1 Completed

BreastGastrointestinal

Biliary Tract Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT02129257 2017-10-24

AMALTHEA

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT00828139 2017-08-21

S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase 2 Completed

189 enrolled 15 charts

Small Cell Lung Carcinoma

NCT00357760 2017-06-23

Ziv-Aflibercept in Treating Patients With Metastatic or Unresectable Kidney Cancer

Phase 2 Completed

94 enrolled 8 charts

Carcinoma, Renal Cell

NCT00729157 2017-03-15

Aflibercept in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy

Phase 2 Completed

41 enrolled 10 charts

EndocrineHead & Neck

Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT01882868 2017-03-14

A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan

Phase 2 Completed

62 enrolled 34 charts

Gastrointestinal

Colorectal Cancer Metastatic

NCT01802684 2017-03-01

VELVET

Phase 2 Completed

Neoplasm Metastasis, Neoplasms

NCT01749956 2017-02-07

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

Phase 2 Completed

39 enrolled 13 charts

Gastrointestinal

Rectal Neoplasms

NCT01670721 2016-11-28

AFEQT

Phase 3 Completed

175 enrolled 6 charts

Gastrointestinal

Colorectal Cancer Metastatic

NCT01661270 2016-10-18

AFLAME

Phase 3 Completed

332 enrolled 9 charts

Gastrointestinal

Colorectal Cancer Metastatic

NCT00519285 2016-07-22

VENICE

Phase 3 Completed

1,224 enrolled 21 charts

Neoplasm Metastasis, Neoplasms, Prostatic Neoplasms

NCT00327171 2016-06-07

Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer

Phase 2 Completed

218 enrolled 19 charts

Neoplasms, Ovarian Neoplasms

NCT00851084 2016-06-07

AFFIRM

Phase 2 Completed

268 enrolled 16 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00036946 2016-06-03

VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Completed

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00045266 2016-06-03

VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Completed

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00082823 2016-06-03

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Completed

GastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmSarcoma

Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Burkitt Lymphoma, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Sarcoma, Testicular Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Endometrial Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00083213 2016-06-03

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Completed

GastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmSarcoma

Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Burkitt Lymphoma, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Sarcoma, Testicular Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Endometrial Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00644124 2016-05-06

Aflibercept and Standard Chemotherapy (R-CHOP) in First Line of Non Hodgkin B-cell Lymphoma

Phase 1 Completed

Lymphoma, Non-Hodgkin

NCT00876044 2016-05-05

QUTIE

Phase 1 Completed

Neoplasms

NCT00390234 2015-12-07

Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma

Phase 2 Completed

63 enrolled 10 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

NCT00369590 2015-10-02

VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide

Phase 2 Completed

58 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT01688960 2015-03-17

Nesvacumab (REGN910/ SAR307746) and Aflibercept ("Ziv-aflibercept" in the U.S.) in Patients With Advanced Solid Malignancies

Phase 1 Completed

Other solid neoplasm

Solid Tumors

NCT01930552 2015-01-07

A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies

Phase 1 Completed

Neoplasms

NCT00407485 2014-10-20

VEGF Trap in Treating Patients With Recurrent, Locally Advanced, or Metastatic Cancer of the Urothelium

Phase 2 Completed

22 enrolled 7 charts

Urinary Bladder Neoplasms, Urethral Neoplasms

NCT00650923 2014-05-30

Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma

Phase 1 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00369655 2014-05-05

VEGF Trap in Treating Patients With Metastatic Breast Cancer

Phase 2 Completed

21 enrolled 22 charts

Breast Neoplasms

NCT00622414 2014-02-24

Aflibercept in Treating Young Patients With Relapsed or Refractory Solid Tumors

Phase 1 Completed

Other solid neoplasm

Unspecified Childhood Solid Tumor, Protocol Specific

NCT00545246 2013-10-16

A Phase I Study of Intravenous Aflibercept in Combination With Docetaxel in Japanese Cancer Patients

Phase 1 Completed

Neoplasms

NCT00396591 2013-01-10

AVE0005 (VEGF Trap) in Patients With Recurrent Symptomatic Malignant Ascites

Phase 2 Completed

16 enrolled 18 charts

Ovarian Neoplasms