Clinical Trials

25 enrolled

Melanoma

NCT03971409 2026-04-17

InCITe

145 enrolled

Breast

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT05026983 2026-04-16

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

35 enrolled

Melanoma

NCT04061980 2026-04-13

Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer

24 enrolled

Head & Neck

Thyroid Neoplasms

NCT05286788 2026-04-08

MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

38 enrolled

CNS

Craniopharyngioma

NCT05170334 2026-04-06

Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma

7 enrolled

Uveal Melanoma, Eye Neoplasms

NCT02910700 2025-12-17

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

52 enrolled

Brain Neoplasms, Melanoma

NCT04526782 2025-11-18

ENCO-BRAF

119 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT05510895 2025-10-01

NeoBRAF

2 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT06887088 2025-10-01

ENCEFALO

33 enrolled

Brain Neoplasms, Melanoma

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT03231306 2025-05-02

NF108-BINI

45 enrolled 8 charts

CNS

Neurofibroma, Neurofibromatosis 1, Peripheral Nervous System Neoplasms, Neurofibromatoses, Neurofibroma, Plexiform

NCT04735068 2025-04-01

Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer

9 enrolled 12 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT03839342 2025-02-03

BEAVER

26 enrolled

Other solid neoplasm

Solid Tumor

NCT04375527 2024-12-04

Binimetinib and Nivolumab for the Treatment of Locally Advanced Unresectable or Metastatic BRAF V600 Wildtype Melanoma

Phase 2 Terminated

3 enrolled

Melanoma

NCT03973918 2024-10-31

BRAF

Phase 2 Terminated

5 enrolled 15 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT03475004 2024-09-19

Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer

53 enrolled 14 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT03981614 2024-08-22

Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer

102 enrolled 11 charts

Colorectal Neoplasms

NCT02631447 2024-06-07

SECOMBIT

251 enrolled

Melanoma

NCT04390243 2024-05-06

Binimetinib and Encorafenib for the Treatment of Pancreatic Cancer in Patients With a Somatic BRAF V600E Mutation

Phase 2 Terminated

6 enrolled 16 charts

Pancreatic Neoplasms

NCT02834364 2023-11-24

GMMG-BIRMA

12 enrolled

Plasma cell

Multiple Myeloma, Recurrence

NCT03563729 2023-07-13

MEMBRAINS

80 enrolled

Brain Neoplasms, Melanoma

NCT05767879 2023-03-14

(Neo)Adjuvant BRAF/MEK Inhibition in pN1c Melanoma

Phase 2 Unknown

28 enrolled

Melanoma

NCT05097378 2021-10-28

PREMIUM

Phase 2 Unknown

45 enrolled

Melanoma, Neoplasms

NCT02263898 2020-07-27

Intermittent LGX818 and MEK162 in Treating Patients With Metastatic Melanoma Who Have BRAFV600 Mutations

Phase 2 Withdrawn