Announcements Trials
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Phase

Phase 1 5Phase 2 3Phase 3 2Phase 2/3 1

Status

Completed 5

Sponsor Class

INDUSTRY 5

Study Type

Interventional 5

Sponsor

Cancer Type

Tumor-Agnostic 2Other solid neoplasm 2CNS 1

Conditions

Solid Tumors 2Neoplasms 2Glioblastoma 1

Interventions

Cyclophosphamide 624pembrolizumab 500Paclitaxel 456Gemcitabine 438Carboplatin 435Cisplatin 418Radiotherapy 380fludarabine 365Nivolumab 340Docetaxel 277Bevacizumab 276Irinotecan 257Magnetic Resonance Spectroscopy 242Fluorouracil 228Dexamethasone 225Specimen Handling 221Capecitabine 218Rituximab 205Cytarabine 201Oxaliplatin 200Ipilimumab 199Temozolomide 197Biopsy 196fludarabine phosphate 194Etoposide 181Lenalidomide 176Doxorubicin 175Leucovorin 173Cetuximab 171Injections 170

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1 × brigimadlin × Clear all
NCT03449381 2026-03-31

This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors)

Boehringer Ingelheim

Phase 1 Completed
266 enrolled
Tumor-Agnostic

Neoplasms

NCT03964233 2026-02-18

A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab) and BI 754111 or BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab)

Boehringer Ingelheim

Phase 1 Completed
119 enrolled
Tumor-Agnostic

Neoplasms

NCT05372367 2026-02-03

A Study in People With Advanced Cancer to Test Whether the Amount of BI 907828 in the Blood is Influenced by Taking an OATP Inhibitor or a CYP3 Inhibitor

Boehringer Ingelheim

Phase 1 Completed
33 enrolled
Other solid neoplasm

Solid Tumors

NCT05376800 2025-08-24

A Study to Determine How BI 907828 (Brigimadlin) is Taken up in the Tumor (Phase 0) and to Determine the Highest Dose of BI 907828 (Brigimadlin) That Could be Tolerated (Phase 1a) in Combination With Radiation Therapy in People With a Brain Tumor Called Glioblastoma

Boehringer Ingelheim

Phase 1 Completed
24 enrolled
CNS

Glioblastoma

NCT05613036 2025-01-22

A Study in People With Advanced Cancer to Test How BI 907828 is Processed in the Body

Boehringer Ingelheim

Phase 1 Completed
13 enrolled
Other solid neoplasm

Solid Tumors

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