Clinical Trials Browser

NIH × Interventional × cixutumumab × Clear all

NCT01142388 2026-05-29

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Phase 2 Active not recruiting

94 enrolled 8 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00617708 2022-02-08

S0727 Gemcitabine Hydrochloride and Erlotinib Hydrochloride With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery

Phase 1/2 Completed

134 enrolled 12 charts

Gastrointestinal

Pancreatic Neoplasms

NCT00887159 2021-01-05

A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients With Extensive Stage

Phase 2 Completed

168 enrolled 11 charts

Small Cell Lung Carcinoma

NCT00684983 2020-03-24

Capecitabine and Lapatinib Ditosylate With or Without Cixutumumab in Treating Patients With Previously Treated HER2-Positive Stage IIIB-IV Breast Cancer

Phase 2 Completed

64 enrolled 13 charts

Insulin-Like Growth Factor I, Resistance To, Breast Neoplasms

NCT01413191 2020-02-19

Cixutumumab in Treating Patients With Metastatic Melanoma of the Eye

Phase 2 Completed

18 enrolled 9 charts

Uveal Melanoma

NCT01026623 2019-06-17

Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer

Phase 1/2 Completed

16 enrolled 12 charts

Prostatic Neoplasms

NCT01614795 2018-12-11

Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma

Phase 2 Completed

46 enrolled 13 charts

Fibrosarcoma, Hemangiosarcoma, Liposarcoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00699491 2018-06-13

Cixutumumab and Temsirolimus in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

Phase 1/2 Completed

48 enrolled 14 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT00955305 2018-06-06

Paclitaxel, Carboplatin, and Bevacizumab With or Without Cixutumumab in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer

Phase 2 Terminated

175 enrolled 8 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT01160458 2018-04-10

Phase II Study of IMC-A12 in Patients With Mesothelioma Who Have Been Previously Treated With Chemotherapy

Phase 2 Completed

20 enrolled 12 charts

Other solid neoplasmThoracic

Mesothelioma, Malignant

NCT01120236 2018-02-26

Bicalutamide and Goserelin or Leuprolide Acetate With or Without Cixutumumab in Treating Patients With Newly Diagnosed Metastatic Prostate Cancer

Phase 2 Completed

211 enrolled 17 charts

Prostatic Neoplasms

NCT01055314 2017-08-29

Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

Phase 2 Completed

175 enrolled 13 charts

Rhabdomyosarcoma, Sarcoma

NCT01182883 2017-07-02

A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors

Phase 1 Withdrawn

Glioma, Pinealoma, Brain Stem Neoplasms

NCT01204476 2016-07-15

Cixutumumab, Everolimus, and Octreotide Acetate in Treating Patients With Advanced Low to Intermediate Grade Neuroendocrine Carcinoma

Phase 1 Completed

CNSDermatologicEndocrine

Glucagonoma, Insulinoma, Paraganglioma, Somatostatinoma, Zollinger-Ellison Syndrome, Carcinoma, Merkel Cell, Carcinoma, Medullary

NCT00720174 2016-05-17

Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma

Phase 1 Completed

Malignant mesenchymal tumor, Hemangiopericytoma, Malignant, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous, Desmoplastic Small Round Cell Tumor

NCT01008566 2016-05-12

Cixutumumab and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer

Phase 1 Completed

Gastrointestinal

Carcinoma, Hepatocellular

NCT01061749 2016-01-25

Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies

Phase 1 Completed

Adult Solid Neoplasm

NCT00678769 2015-11-04

Cixutumumab and Temsirolimus in Treating Patients With Locally Advanced or Metastatic Cancer

Phase 1 Completed

Neoplasms

NCT01016015 2015-07-30

Temsirolimus and Cixutumumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Soft Tissue Sarcoma or Bone Sarcoma

Phase 2 Completed

178 enrolled 6 charts

Sarcoma, Osteosarcoma

NCT00831844 2015-03-30

Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors

Phase 2 Completed

116 enrolled 8 charts

CNSEndocrineGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Hepatoblastoma, Adrenocortical Carcinoma

NCT00986674 2014-09-26

Carboplatin and Paclitaxel Combined With Cetuximab and/or IMC-A12 in Patients With Advanced Non-Small Cell Lung Cancer

Phase 2 Completed

140 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung

NCT00609141 2014-06-19

IMC-A12 in Treating Young Patients With Relapsed or Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor or Other Solid Tumor

Phase 1 Completed

Neuroectodermal Tumors, Primitive, Peripheral

NCT00639509 2014-05-23

IMC-A12 in Treating Patients With Advanced Liver Cancer

Phase 2 Completed

24 enrolled 8 charts

Gastrointestinal

Carcinoma, Hepatocellular

NCT00778167 2014-05-21

Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

Phase 1/2 Completed

18 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung

NCT00778817 2014-04-29

IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery

Phase 2 Terminated

20 enrolled 17 charts

Adrenocortical Carcinoma

NCT00880282 2014-04-29

Cixutumumab and Temsirolimus in Treating Younger Patients With Solid Tumors That Have Recurred or Not Responded to Treatment

Phase 1 Completed

Other solid neoplasm

Unspecified Childhood Solid Tumor, Protocol Specific