Clinical Trials Browser

Pancreatic cancer, adult, Digestive System Neoplasms, Endocrine Gland Neoplasms, Adenoma, Islet Cell, Pancreatic Diseases, Pancreatic Neoplasms, Carcinoma, Islet Cell, Carcinoma, Pancreatic Ductal

NCT03810742 2023-11-18

Nanoliposomal Irinotecan (Nal-IRI, ONIVYDE®) in Combination With TAS-102 (LONSURF®) in Refractory Solid Tumors

Phase 1 Completed

44 enrolled

Other solid neoplasm

Refractory Solid Tumors

NCT02022644 2023-06-29

Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma

Phase 1 Completed

18 enrolled

CNS

Glioma

NCT03086616 2023-04-06

CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)

Phase 1 Completed

6 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT03883919 2022-10-05

Liposomal Irinotecan Plus 5-FU / LV Combined With Paricalcitol in Patients With Advanced Pancreatic Cancer Progressed on Gemcitabine-based Therapy

Phase 1 Completed

20 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT04088786 2022-05-06

Phase I Trial HIPEC With Nal-irinotecan

Phase 1 Completed

18 enrolled

GastrointestinalOther solid neoplasmThoracic

Adenocarcinoma, Mucinous, Mesothelioma, Pseudomyxoma Peritonei, Stomach Neoplasms, Colorectal Neoplasms, Neoplasms, Cystic, Mucinous, and Serous

NCT02013336 2022-03-31

Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

Phase 1 Unknown

30 enrolled

CNSSarcoma

Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05086822 2021-10-21

A Study of Irinotecan Hydrochloride Liposome in Advanced Solid Tumors

Phase 1 Completed

32 enrolled

Other solid neoplasm

Advanced Solid Tumors

NCT03703063 2021-01-27

Alternative Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer

Phase 1 Unknown

30 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT03207724 2020-12-30

OnFX

Phase 1 Completed

16 enrolled

Gastrointestinal

Adenocarcinoma, Cachexia, Disease, Pancreatic Neoplasms, Weight Loss

NCT00062842 2020-03-04

Study of Irinotecan on a Weekly Schedule in Children

Phase 1 Completed

23 enrolled

Tumor-Agnostic

Neoplasms

NCT01770353 2019-11-27

MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment

Phase 1 Completed

45 enrolled 33 charts

BreastGastrointestinalGynecologicHead & Neck

Head and Neck Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT00364143 2019-07-05

Safety Study of IHL-305 (Irinotecan Liposome Injection) to Treat Advanced Solid Tumors

Phase 1 Completed

40 enrolled

Tumor-Agnostic

Neoplasms

NCT02640365 2017-01-31

DOUBLIRI

Phase 1 Completed

10 enrolled

Tumor-Agnostic

Neoplasms

NCT02884128 2016-08-30

A Study of PEP02 in Combination With 5-fluorouracil (5-FU) and Leucovorin (LV) in Advanced Solid Tumors

Phase 1 Completed

16 enrolled

Other solid neoplasm

Solid Tumor

NCT00734682 2015-01-07

A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas

Phase 1 Completed

34 enrolled

CNSSarcoma

Astrocytoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

Clinical Trials

A Study of ASP3082 in Adults With Advanced Solid Tumors

Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Toripalimab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement

NALIRIFOX (Nal-IRI Plus 5-FU/LV Plus Oxaliplatin) as First-Line Treatment for Patients With Advanced Small Intestine and Appendiceal Cancers

PIPAC-NAL-IRI

SIRACUSA

Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors

Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)

Irinotecan Liposomes Combined with Temozolomide and Vincristine in the Treatment of Pediatric Patients with Solid Tumors

Study of Irinotecan Liposome Injection in Patients With Advanced Breast Cance

Dose Escalation and Expansion Clinical Trial of Irinotecan Liposome Combined With Oxaliplatin and 5-FU/LV Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer

A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer

Nanoliposomal Irinotecan (Nal-IRI, ONIVYDE®) in Combination With TAS-102 (LONSURF®) in Refractory Solid Tumors

Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma

CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)

Liposomal Irinotecan Plus 5-FU / LV Combined With Paricalcitol in Patients With Advanced Pancreatic Cancer Progressed on Gemcitabine-based Therapy

Phase I Trial HIPEC With Nal-irinotecan

Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

A Study of Irinotecan Hydrochloride Liposome in Advanced Solid Tumors

Alternative Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer

OnFX

Study of Irinotecan on a Weekly Schedule in Children

MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment

Safety Study of IHL-305 (Irinotecan Liposome Injection) to Treat Advanced Solid Tumors

DOUBLIRI

A Study of PEP02 in Combination With 5-fluorouracil (5-FU) and Leucovorin (LV) in Advanced Solid Tumors

A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas