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Phase

Phase 2 21Phase 4 5Phase 1 5Phase 1/2 4Phase 3 3Phase EARLY_PHASE1 1

Status

Completed 2Active not recruiting 2Not yet recruiting 1

Sponsor Class

INDUSTRY 3OTHER 2

Study Type

Interventional 5

Sponsor

Cancer Type

Thoracic 4Tumor-Agnostic 1CNS 1

Conditions

Carcinoma, Non-Small-Cell Lung 2NSCLC 1Meningeal Carcinomatosis 1Carcinoma 1Brain Neoplasms 1Advanced Non-Small Cell Lung Cancer 1

Interventions

Dexamethasone 56Metformin 50Cyclophosphamide 47Saline Solution 39Cytarabine 37Cisplatin 36Zoledronic Acid 34Letrozole 34Carboplatin 33Sodium Chloride 32Bupivacaine 31Docetaxel 30Bevacizumab 30Vincristine 29Methotrexate 29Fluorouracil 28Propofol 27Capecitabine 27Fentanyl 26Doxorubicin 26Rituximab 25Drug Therapy 25Dexmedetomidine 25Prednisone 23Paclitaxel 23Oxaliplatin 21Morphine 21Gemcitabine 21Radiotherapy 19Prednisolone 19

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 4 × Interventional × lorlatinib × Clear all
NCT06282874 2026-04-09

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

Guangdong Association of Clinical Trials

Phase 4 Active not recruiting
41 enrolled
CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05144997 2025-12-17

Lorlatinib Continuation Study

Pfizer

Phase 4 Active not recruiting
76 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT04362072 2025-06-11

Study of Lorlatinib In People With ALK-positive Non-small Cell Lung Cancer

Pfizer

Phase 4 Completed
71 enrolled 26 charts
Tumor-Agnostic

Carcinoma

NCT06893354 2025-03-25

Explore the Mechanisms Underlying Disease Resistance and Potential Primary Resistance Mechanism of Induction Therapy Lorlatinib in Resectable Non-small Cell Lung Cancer (NSCLC) Harboring ALK Positive Mutation Revealed by Single-cell RNA Sequencing and Spatial Transcriptomics

The First Affiliated Hospital of Guangzhou Medical University

Phase 4 Not yet recruiting
20 enrolled
Thoracic

NSCLC

NCT04541706 2024-12-20

Lorlatinib in ALK Inhibitor Treated Unresectable Advanced/Recurrent ALK-Positive Non Small Cell Lung Cancer Patients in India

Pfizer

Phase 4 Completed
100 enrolled 10 charts
Thoracic

Advanced Non-Small Cell Lung Cancer

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