Announcements Trials
Browse Landscape

Phase

Phase 2 2Phase 1/2 2Phase 1 2

Status

Terminated 4Completed 1Active not recruiting 1

Sponsor Class

OTHER 13INDUSTRY 6NIH 2

Study Type

Interventional 6Expanded_access 1

Sponsor

Cancer Type

Other solid neoplasm 2Thoracic 1Gastrointestinal 1Dermatologic 1CNS 1Breast 1

Conditions

Solid Tumor, Adult 1Neurofibromatosis 1 1Neurofibromatoses 1Neurofibroma, Plexiform 1Neurofibroma 1Melanoma 1Colonic Neoplasms 1Carcinoma, Non-Small-Cell Lung 1Breast Neoplasms 1Advanced Solid Tumor 1Advanced Cancer 1

Interventions

pembrolizumab 1019Carboplatin 959Paclitaxel 932Gemcitabine 793Cisplatin 748Docetaxel 682Bevacizumab 610Pemetrexed 502Nivolumab 486Cyclophosphamide 466Capecitabine 461Fluorouracil 417Dexamethasone 402Rituximab 372Oxaliplatin 347Injections 342atezolizumab 297Trastuzumab 297Leucovorin 286Cetuximab 282Irinotecan 266130-nm albumin-bound paclitaxel 252Prednisone 244Doxorubicin 240Ipilimumab 226Lenalidomide 220Fulvestrant 217fludarabine 214durvalumab 205Erlotinib Hydrochloride 188

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
INDUSTRY × Interventional × mirdametinib × Clear all
NCT03962543 2026-05-06

ReNeu

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Phase 2 Active not recruiting
114 enrolled 25 charts 1 FDA
CNS

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT05580770 2026-05-01

Mirdametinib + BGB-3245 in Advanced Solid Tumors

SpringWorks Therapeutics, Inc.

Phase 1/2 Terminated
23 enrolled 22 charts
Other solid neoplasm

Advanced Solid Tumor

NCT03905148 2026-01-07

Study of the Safety and Pharmacokinetics of BGB-283 (Lifirafenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors

BeOne Medicines

Phase 1 Completed
91 enrolled
Other solid neoplasm

Solid Tumor, Adult

NCT01347866 2018-10-29

Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer

Pfizer

Phase 1 Terminated
105 enrolled 64 charts

Advanced Cancer

NCT00147550 2013-09-13

MEK Inhibitor PD-325901 To Treat Advanced Breast Cancer, Colon Cancer, And Melanoma.

Pfizer

Phase 1/2 Terminated
79 enrolled
BreastDermatologicGastrointestinal

Breast Neoplasms, Colonic Neoplasms, Melanoma

NCT00174369 2009-03-17

MEK Inhibitor PD-325901 To Treat Advanced Non-Small Cell Lung Cancer

Pfizer

Phase 2 Terminated
34 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

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