Clinical Trials Browser

Phase 1 × neratinib × Clear all

NCT05372614 2026-05-18

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Phase 1 Suspended

Neoplasm Metastasis

NCT04502602 2026-05-11

iNNOVATE

Phase 1 Active not recruiting

Ovarian Neoplasms

NCT03065387 2026-01-12

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Phase 1 Active not recruiting

Neoplasm Metastasis

NCT05274048 2025-10-29

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

Phase 1 Recruiting

Gastrointestinal

Gastrointestinal Neoplasms, Stomach Neoplasms

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT01128842 2018-12-19

A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid Tumor

Phase 1 Completed

7 enrolled 13 charts

Other solid neoplasm

Advanced Malignant Solid Tumors

NCT00768469 2018-11-19

Study Evaluating Safety And Tolerability, Solid Tumor

Phase 1 Completed

10 enrolled 11 charts

Other solid neoplasm

Advanced Malignant Solid Tumors

NCT00838539 2018-09-18

Study Evaluating Neratinib In Combination With Temsirolimus In Subjects With Solid Tumors

Phase 1 Completed

63 enrolled 26 charts

Neoplasms

NCT00146172 2018-09-17

Study Evaluating HKI-272 in Tumors

Phase 1 Completed

73 enrolled 20 charts

Breast Neoplasms, Neoplasms

NCT00397046 2018-09-14

A Study Of The Safety And Tolerability Of HKI-272 Administered Orally To Japanese Subjects With Advanced Solid Tumors

Phase 1 Completed

21 enrolled 13 charts

Neoplasms

NCT00958724 2018-06-28

Study Evaluating Neratinib In Combination With Vinorelbine In Subjects With Advanced Or Metastatic Solid Tumors

Phase 1 Completed

6 enrolled 13 charts

Other solid neoplasm

Advanced Malignant Solid Tumors

NCT02593708 2017-11-17

Phase1 of Neratinib+Trastuzumab, Pertuzumab, Paclitaxel in Patients With Advanced Solid Tumors/HER2+

Phase 1 Terminated

Other solid neoplasm

Solid Tumor

NCT00366600 2017-09-11

Study Evaluating HKI-272 Administered to Healthy Subjects

Phase 1 Completed

Breast Neoplasms

NCT01423123 2014-07-08

Combination of Weekly Paclitaxel With Neratinib and Trastuzumab in Women With Metastatic HER2-positive Breast Cancer

Phase 1 Completed

Breast Neoplasms

NCT00708903 2012-05-14

Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization)

Phase 1 Completed

Breast Neoplasms