NCT04722146 2026-04-13
MajesTEC-2
Janssen Research & Development, LLC
Phase 1 Active not recruiting
Clinical Trials
19 trialsNCT07170644 2026-04-06
A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)
SpringWorks Therapeutics, Inc.
Phase 2 Active not recruiting
NCT07176689 2026-04-06
Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
SpringWorks Therapeutics, Inc.
Phase 4 Recruiting
NCT05041036 2026-04-01
Individual Patient Compassionate Use of Nirogacestat
SpringWorks Therapeutics, Inc.
Available
NCT05090566 2026-02-23
MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma
Pfizer
Phase 2 Active not recruiting
NCT05137054 2026-01-22
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
Regeneron Pharmaceuticals
Phase 1 Recruiting
NCT05348356 2025-12-15
Nirogacestat in Ovarian Granulosa Cell Tumors
SpringWorks Therapeutics, Inc.
Phase 2 Completed
NCT04126200 2025-11-06
DREAMM5
GlaxoSmithKline
Phase 2 Active not recruiting
NCT07150091 2025-09-02
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM
GlaxoSmithKline
Phase 1/2 Active not recruiting
NCT07150104 2025-09-02
Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Nirogacestat, Pomalidomide, and Dexamethasone in Participants With RRMM
GlaxoSmithKline
Phase 1/2 Active not recruiting
NCT07084896 2025-07-25
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM
GlaxoSmithKline
Phase 1/2 Active not recruiting
NCT03785964 2025-01-31
DeFi
SpringWorks Therapeutics, Inc.
Phase 3 Completed
NCT04171843 2023-09-21
A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
Precision BioSciences, Inc.
Phase 1 Terminated
NCT04093596 2023-08-14
UNIVERSAL
Allogene Therapeutics
Phase 1 Active not recruiting
NCT00878189 2019-11-12
A Trial In Patients With Advanced Cancer And Leukemia
Pfizer
Phase 1 Completed
NCT01876251 2019-03-15
A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer
Pfizer
Phase 1 Terminated
NCT02109445 2019-01-10
Study Of PF-03084014 In Combination With Gemcitabine And Nab-Paclitaxel In Patients With Metastatic Pancreatic Adenocarcinoma Not Previously Treated With Anticancer Therapies
Pfizer
Phase 2 Terminated
NCT02299635 2019-01-08
A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations
Pfizer
Phase 2 Terminated
NCT02462707 2015-10-07
A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors
Pfizer
Phase 1 Withdrawn