Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Phase 2 Recruiting
2,900 enrolled
Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors
Phase 2 Recruiting
89 enrolled
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
Phase 2 Recruiting
152 enrolled
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial
Phase 2 Recruiting
165 enrolled
An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib
Phase 2 Recruiting
53 enrolled
A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies
Phase 2 Recruiting
377 enrolled
TAPUR
Phase 2 Recruiting
4,200 enrolled
Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma
Phase 2 Recruiting
37 enrolled
ORCHID
Phase 2 Recruiting
20 enrolled
CAPTUR
Phase 2 Recruiting
720 enrolled
I-SPY
Phase 2 Recruiting
5,000 enrolled
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)
Phase 2 Recruiting
372 enrolled
DAPA-ARMOR
Phase 2 Recruiting
46 enrolled
Pembrolizumab, Olaparib, and Temozolomide for People With Glioma
Phase 2 Recruiting
57 enrolled
Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer
Phase 2 Recruiting
60 enrolled
Surgical Pembro +/- Olaparib w TMZ for rGBM
Phase 2 Recruiting
78 enrolled
A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer
Phase 2 Recruiting
34 enrolled
Pembro With Radiation With or Without Olaparib
Phase 2 Recruiting
64 enrolled
NePtune
Phase 2 Recruiting
32 enrolled
Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.
Phase 2 Recruiting
38 enrolled
Randomized Trial Comparing Standard of Care Versus Immune- Based Combination in Relapsed Stage III Non-small-cell Lung Cancer (NSCLC) Pretreated With Chemoradiotherapy and Durvalumab
Phase 2 Recruiting
176 enrolled
ELEMENT
Phase 2 Recruiting
176 enrolled
WoO
Phase 2 Recruiting
60 enrolled
NeoADAPT
Phase 2 Recruiting
30 enrolled
Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer
Phase 2 Recruiting
20 enrolled
COBRA
Phase 2 Recruiting
100 enrolled
PHOENIX
Phase 2 Recruiting
119 enrolled
MOST plus
Phase 2 Recruiting
900 enrolled
Phase II Study of the Combination of Durvalumab (MEDI4736) (PDL1 Inhibitor) and Olaparib (PARP Inhibitor) in Advanced Cholangiocarcinoma After Initial Chemotherapy and Durvalumab (BIL-PPP)
Phase 2 Recruiting
40 enrolled
THOR
Phase 2 Recruiting
60 enrolled
Olaparib in Patients With HRD Malignant Mesothelioma
Phase 2 Recruiting
56 enrolled
Post-CDK
Phase 2 Recruiting
64 enrolled
Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer
Phase 2 Recruiting
150 enrolled
Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)
Phase 2 Recruiting
240 enrolled
Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer
Phase 2 Recruiting
23 enrolled
Surgery Combined With Maintenance Targeted Therapy in the Treatment of Advanced Ovarian Cancer
Phase 2 Recruiting
220 enrolled
OPTIMUM
Phase 2 Recruiting
62 enrolled
Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion
Phase 2 Recruiting
300 enrolled
SOLID
Phase 2 Recruiting
58 enrolled
STROBE
Phase 2 Recruiting
100 enrolled
PALBOLA
Phase 2 Recruiting
16 enrolled
DRUP
Phase 2 Recruiting
1,550 enrolled
POINT
Phase 2 Recruiting
30 enrolled