Announcements Trials
Browse Landscape

Phase

Phase 1 6Phase 1/2 3

Status

Terminated 2Active not recruiting 2Withdrawn 1Completed 1

Sponsor Class

INDUSTRY 4OTHER 1NIH 1

Study Type

Interventional 6

Sponsor

Cancer Type

Thoracic 3Sarcoma 1Other hematologic neoplasm 1NET 1Lymphoid 1Gynecologic 1Endocrine 1

Conditions

Small Cell Lung Carcinoma 2Recurrence 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Neuroendocrine Tumors 1Fallopian Tube Neoplasms 1Endometrial Neoplasms 1EGFR Positive Non-small Cell Lung Cancer 1Carcinosarcoma 1

Interventions

Cyclophosphamide 624pembrolizumab 500Paclitaxel 456Gemcitabine 438Carboplatin 435Cisplatin 418Radiotherapy 380fludarabine 365Nivolumab 340Docetaxel 277Bevacizumab 276Irinotecan 257Magnetic Resonance Spectroscopy 242Fluorouracil 228Dexamethasone 225Specimen Handling 221Capecitabine 218Rituximab 205Cytarabine 201Oxaliplatin 200Ipilimumab 199Temozolomide 197Biopsy 196fludarabine phosphate 194Etoposide 181Lenalidomide 176Doxorubicin 175Leucovorin 173Cetuximab 171Injections 170

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
Phase 1 × Interventional × pelcitoclax × Clear all
NCT05691504 2026-05-13

Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

National Cancer Institute (NCI)

Phase 1 Active not recruiting
42 enrolled
GynecologicSarcoma

Carcinosarcoma, Fallopian Tube Neoplasms, Endometrial Neoplasms

NCT07428486 2026-05-07

A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

Phase 1 Withdrawn
LymphoidOther hematologic neoplasm

Recurrence, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04001777 2025-10-01

A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC Patients

Ascentage Pharma Group Inc.

Phase 1 Active not recruiting
80 enrolled
Thoracic

EGFR Positive Non-small Cell Lung Cancer

NCT04893759 2025-04-17

A Study of Pelcitoclax (APG-1252) in Patients With Neuroendocrine Tumors

Ascentage Pharma Group Inc.

Phase 1 Terminated
2 enrolled
EndocrineNET

Neuroendocrine Tumors

NCT03080311 2022-07-12

A Study of APG-1252 in Patients With SCLC or Other Solid Tumors

Ascentage Pharma Group Inc.

Phase 1 Completed
50 enrolled
Thoracic

Small Cell Lung Carcinoma

NCT03387332 2021-08-27

APG-1252 in Patients With SCLC or Advanced Solid Tumors

Ascentage Pharma Group Inc.

Phase 1 Terminated
24 enrolled
Thoracic

Small Cell Lung Carcinoma

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