Clinical Trials

132 enrolled

Tumor-Agnostic

Neoplasms

NCT04234113 2026-03-27

Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

115 enrolled 43 charts

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT05346484 2026-03-06

MAST

66 enrolled

Bile Duct Neoplasms, Neoplasm Metastasis, Cholangiocarcinoma

NCT03237572 2026-02-09

Breast-48

13 enrolled 10 charts

Breast

Breast Neoplasms

NCT04166734 2026-02-04

MESO-PRIME

Other solid neoplasmThoracic

5 enrolled 13 charts

Mesothelioma

NCT03436056 2026-01-29

PRIMING

2 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT05194072 2026-01-09

A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors

BreastGastrointestinalGynecologicThoracic

250 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT05676749 2026-01-05

C-TIL051 in Non-Small Cell Lung Cancer

1 enrolled

Carcinoma, Non-Small-Cell Lung

NCT03260504 2025-12-08

Aldesleukin and Pembrolizumab in Treating Patients With Advanced or Metastatic Kidney Cancer

6 enrolled 11 charts

Genitourinary

Clear-cell metastatic renal cell carcinoma, Carcinoma, Renal Cell

NCT06171178 2025-11-04

A Study of ASP1012 in Adults With Solid Tumors

15 enrolled

Dermatologic

Melanoma

NCT05859464 2025-10-20

A Phase 1 Study of ZL-1218 in Subjects With Advanced Solid Tumors

34 enrolled

Malignant Solid Tumor

NCT03792841 2025-10-16

Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

212 enrolled

Genitourinary

Bites and Stings, Prostatic Neoplasms

NCT03307759 2025-09-15

SABRseq

13 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung

NCT05369000 2025-08-01

Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer (mCRPC) Resistant Prostate Cancer

96 enrolled

Genitourinary

Prostatic Neoplasms

NCT04904185 2025-07-25

ImmPACT Expanded Multiple Antigen Specific Endogenously Derived T Cells (MASE-T) to Patients With Metastatic Melanoma

8 enrolled 8 charts

Dermatologic

Melanoma

NCT03249792 2025-07-24

MK-2118-001

140 enrolled 37 charts

Lymphoid

Lymphoma

NCT02419495 2025-06-04

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

BreastDermatologicGenitourinaryGynecologicThoracic

221 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Fallopian Tube Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT03432741 2025-05-26

Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer

BreastDermatologicLymphoid

17 enrolled

Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Mycosis Fungoides, Lymphoma, T-Cell, Cutaneous, Lymphoma, B-Cell, Marginal Zone

NCT03286114 2025-05-11

Augmentation of the Graft vs. Leukemia Effect Via Checkpoint Blockade With Pembrolizumab

LymphoidMyeloidOther hematologic neoplasm

16 enrolled 13 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04301011 2025-04-23

RAPTOR

DermatologicGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

27 enrolled

Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Melanoma, Mesothelioma, Oropharyngeal Neoplasms, Skin Neoplasms

NCT05267470 2025-03-25

FORTITUDE-201

74 enrolled 22 charts

Squamous-Cell Non-Small-Cell Lung Cancer

NCT05446129 2025-03-13

A Study in People With Colorectal Cancer to Test Whether Ezabenlimab or Pembrolizumab in Combination With BI 765063 Lead to Side Effects or Delays in Surgery

2 enrolled 9 charts

Colorectal Neoplasms

NCT05166577 2025-03-12

Nanatinostat Plus Valganciclovir in Advanced EBV+ Solid Tumors and in Combination With Pembrolizumab in EBV+ RM-NPC

26 enrolled 23 charts

Head & Neck

Nasopharyngeal Carcinoma

NCT05576077 2025-03-10

STARLING

BreastDermatologicGastrointestinalHead & NeckThoracic

31 enrolled

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms

NCT04999202 2025-02-10

A Study to Learn How Safe the Study Drug BAY 2416964 (AhR Inhibitor) in Combination With the Treatment Pembrolizumab is, How This Combination Affects the Body, the Maximum Amount That Can be Given, How it Moves Into, Through and Out of the Body and Its Action Against Advanced Solid Cancers in Adults

47 enrolled

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT03948763 2025-01-28

V941-001

70 enrolled 18 charts

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04074759 2025-01-23

FPT155-001

80 enrolled 49 charts

Advanced Solid Tumors

NCT02972034 2024-11-21

MK-8353-013

111 enrolled 30 charts

Neoplasms, Colorectal Neoplasms

NCT04135352 2024-11-12

V938-001

35 enrolled 21 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Neoplasm Metastasis

NCT03833427 2024-11-07

MK-5618-001

32 enrolled 17 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body

NCT03799003 2024-11-01

A Study of ASP1951 in Subjects With Advanced Solid Tumors

DermatologicGastrointestinalGynecologicHead & Neck

119 enrolled

Squamous Cell Carcinoma of Head and Neck, Uterine Cervical Neoplasms, Melanoma, Neoplasms, Colorectal Neoplasms

NCT03809624 2024-10-23

PDL1x41BB

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

160 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Oropharyngeal Neoplasms, Stomach Neoplasms

NCT03996473 2024-10-10

Study to Test the Safety and How Radium-223 Dichloride an Alpha Particle-emitting Radioactive Agent Works in Combination With Pembrolizumab an Immune Checkpoint Inhibitor in Patients With Stage IV Non-small Cell Lung Cancer With Bone Metastases

8 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung

NCT03716596 2024-09-20

CISPD-2

8 enrolled

Pancreatic Neoplasms

NCT05996445 2024-08-23

A Study of XmAb®662 as Monotherapy or in Combination With Pembrolizumab in Advanced Solid Tumors

7 enrolled

Solid Tumors

NCT02707666 2024-07-31

A Pilot Window-Of-Opportunity Study of the Anti-PD-1 Antibody Pembrolizumab in Patients With Resectable Malignant Pleural Mesothelioma

Other solid neoplasmThoracic

7 enrolled

Mesothelioma, Malignant

NCT03621982 2024-06-13

Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

78 enrolled 39 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms

NCT04682431 2024-03-22

A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

BreastGastrointestinalHead & NeckThoracic

127 enrolled

Adenocarcinoma of Lung, Breast Neoplasms, Head and Neck Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04691375 2024-03-22

A Study of PY314 in Subjects With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicThoracic

86 enrolled

Adenocarcinoma of Lung, Breast Neoplasms, Carcinoma, Renal Cell, Ovarian Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04478695 2024-03-08

Study of AMG 330 in Combination With Pembrolizumab in Adult With Relapsed or Refractory Acute Myeloid Leukemia

Other hematologic neoplasm

1 enrolled 2 charts

Recurrence, Leukemia, Myeloid, Acute

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

2 enrolled

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT04920383 2024-03-01

NEON-2

29 enrolled

Lymphoid

Lymphoma

NCT04624113 2024-02-21

Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma

13 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04564417 2024-01-31

First-In-Human (FIH) Study of W0180 as Single Agent and in Combination With Pembrolizumab in Adults With Locally Advanced or Metastatic Solid Tumors

33 enrolled

Locally Advanced or Metastatic Solid Tumors

NCT04609579 2024-01-30

Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma

GastrointestinalGynecologicLymphoid

27 enrolled

Bites and Stings, Lymphoma, Ovarian Neoplasms, Colorectal Neoplasms, Lymphoma, B-Cell

NCT04244552 2023-12-29

A Phase 1b Trial of ATRC-101 in Adults With Advanced Solid Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

87 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04187872 2023-12-27

TORCH

CNSDermatologicGastrointestinalGenitourinaryGynecologicThoracic

10 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma

NCT04513067 2023-12-08

A Safety Study of YQ23 in Advanced Solid Tumors Patients

3 enrolled

Advanced Solid Tumor

NCT02530502 2023-11-18

Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma