Clinical Trials Browser

Phase 1 × Interventional × sonidegib × Clear all

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT02195973 2026-02-09

Phase IB Trial of LDE225 and Paclitaxel in Recurrent Ovarian Cancer

Phase 1 Completed

15 enrolled

Gynecologic

Ovarian Neoplasms

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Phase 1 Completed

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT02027376 2023-04-03

EDALINE

Phase 1 Completed

12 enrolled 16 charts

Breast

Advanced Breast Cancer

NCT00880308 2020-12-19

Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors

Phase 1 Completed

103 enrolled

CNSDermatologic

Carcinoma, Basal Cell, Medulloblastoma

NCT01208831 2020-12-19

An East Asian Study of LDE225

Phase 1 Completed

45 enrolled

CNSDermatologic

Carcinoma, Basal Cell, Medulloblastoma

NCT01576666 2020-12-19

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Phase 1 Completed

120 enrolled

BreastCNSGastrointestinal

Breast Neoplasms, Glioblastoma, Stomach Neoplasms, Colorectal Neoplasms

NCT01769768 2020-12-19

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Phase 1 Completed

114 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT01456676 2020-12-09

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Phase 1 Completed

11 enrolled

MyeloidOther hematologic neoplasm

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

NCT01485744 2020-08-04

LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer

Phase 1 Completed

39 enrolled

Gastrointestinal

Neoplasm Metastasis, Pancreatic Neoplasms

NCT01954355 2019-12-06

LDE225 and Paclitaxel in Solid Tumors

Phase 1 Completed

30 enrolled

Gynecologic

Ovarian Neoplasms

NCT02129101 2019-10-30

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

Phase 1 Completed

63 enrolled

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Polycythemia Vera, Thrombocythemia, Essential, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Myelodysplastic-Myeloproliferative Diseases, Primary Myelofibrosis

NCT02182622 2019-06-19

LDE225 + Docetaxel/Prednisone for Adv/Met Castrate Resistant Prostate Cancer w/ Disease Progression After Docetaxel

Phase 1 Withdrawn

Genitourinary

Prostatic Neoplasms

NCT02111187 2019-03-07

LDE225

Phase 1 Completed

14 enrolled 9 charts

Genitourinary

Prostatic Neoplasms

NCT02151864 2019-03-05

LDE225 in Patients With Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis

Phase 1 Completed

9 enrolled

Gastrointestinal

Fibrosis, Carcinoma, Hepatocellular, Liver Neoplasms

NCT01579929 2017-08-17

Combination of the Hedgehog Inhibitor, LDE225, With Etoposide and Cisplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Phase 1 Completed

19 enrolled

Thoracic

Lung Neoplasms

Clinical Trials

Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors

Phase IB Trial of LDE225 and Paclitaxel in Recurrent Ovarian Cancer

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

EDALINE

Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors

An East Asian Study of LDE225

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer

LDE225 and Paclitaxel in Solid Tumors

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

LDE225 + Docetaxel/Prednisone for Adv/Met Castrate Resistant Prostate Cancer w/ Disease Progression After Docetaxel

LDE225

LDE225 in Patients With Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis

Combination of the Hedgehog Inhibitor, LDE225, With Etoposide and Cisplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC)