Clinical Trials Browser

Phase 2 × sotorasib × Clear all

NCT05564377 2026-05-27

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Phase 2 Recruiting

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Endometrial Neoplasms

NCT07172919 2026-05-14

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

Phase 2 Recruiting

Other solid neoplasm

Advanced Solid Tumors

NCT05638295 2026-05-13

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Phase 2 Active not recruiting

Neoplasm Metastasis

NCT05118854 2026-05-04

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

Phase 2 Recruiting

Lung Neoplasms

NCT05398094 2026-04-30

MERIT-lung

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT07543172 2026-04-21

CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer

Phase 2 Not yet recruiting

Lung Neoplasms

NCT06582771 2026-03-25

A Study of Sotorasib in People With Non-Small Cell Lung Cancer

Phase 2 Recruiting

Non Small Lung Cancer

NCT05845450 2026-03-12

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT06333678 2026-01-29

A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung

NCT05054725 2026-01-06

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Phase 2 Completed

47 enrolled 17 charts

Bronchial Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Respiratory Tract Diseases, Respiratory Tract Neoplasms

NCT04625647 2025-12-05

Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Phase 2 Active not recruiting

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04933695 2025-10-22

CodeBreaK201

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung

NCT07124884 2025-08-15

COLOSOTO

Phase 2 Not yet recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05631249 2025-05-08

CODEBREAK-IGR

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung

NCT06068153 2024-11-20

AMBER

Phase 2 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT05815186 2024-03-29

Ladarixin With Sotorasib in Advanced NSCLC - Phase II

Phase 2 Withdrawn

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05311709 2023-11-09

SOLUCOM

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT05993455 2023-08-15

A Phase 2 Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and Panitumumab

Phase 2 Unknown

Efficacy

NCT05400577 2023-07-17

Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC

Phase 2 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT05451056 2022-07-11

breakthrough

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung