Clinical Trials

2,900 enrolled

Gynecologic

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Endometrial Neoplasms

NCT05638295 2026-04-16

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

105 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT06333951 2026-04-13

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

500 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT07012031 2026-04-13

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Phase 1/2 Recruiting

37 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT07172919 2026-04-09

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

14 enrolled

Advanced Solid Tumors

NCT06249282 2026-04-03

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

15 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT06252649 2026-04-02

CodeBreaK 301

Phase 3 Recruiting

450 enrolled

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT06582771 2026-03-25

A Study of Sotorasib in People With Non-Small Cell Lung Cancer

39 enrolled

Non Small Lung Cancer

NCT06804824 2026-03-18

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

220 enrolled

Advanced Solid Tumors

NCT05845450 2026-03-12

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

197 enrolled

Gastrointestinal

Colorectal Neoplasms

NCT05920356 2026-02-27

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Phase 3 Recruiting

750 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT05815173 2025-12-30

Ladarixin With Sotorasib in Advanced NSCLC

40 enrolled

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05118854 2025-10-20

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

27 enrolled

Lung Neoplasms

NCT06807619 2025-05-22

A Study of Sotorasib in People With Brain Tumors

16 enrolled

CNS

Brain Neoplasms

NCT05631249 2025-05-08

CODEBREAK-IGR

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05398094 2025-04-10

MERIT-lung

19 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05036291 2025-03-05

A Study of NB004 as Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors

120 enrolled

Advanced Solid Tumor

NCT06532149 2024-08-09

EROS

Recruiting

80 enrolled

OtherThoracic

Carcinoma, Non-Small-Cell Lung, Eunuchism, Erectile Dysfunction, Sexual Dysfunction, Physiological

NCT04092673 2024-05-21

Zotatifin

Phase 1/2 Recruiting

30 enrolled