Clinical Trials Browser

NCT04997902 2025-12-23

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Recurrence

NCT04809233 2025-06-04

Expanded Access to Tipifarnib

Available

Lymphoid

Lymphoma, Lymphoma, T-Cell, Peripheral

NCT02807272 2024-07-17

CMML/AML

Phase 2 Completed

44 enrolled 17 charts

Other hematologic neoplasm

Leukemia, Myelomonocytic, Chronic

NCT02383927 2024-07-11

Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations

Phase 2 Completed

63 enrolled 19 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Thyroid Neoplasms

NCT02464228 2024-06-26

PTCL

Phase 2 Completed

65 enrolled 16 charts

Lymphoid

Lymphoma, Recurrence, Lymphoma, T-Cell, Peripheral, Lymphoma, Extranodal NK-T-Cell

NCT03719690 2024-06-21

AIM-HN/SEQ-HN

Phase 2 Completed

296 enrolled 27 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04865159 2023-09-21

Cardiovascular Safety Study of Tipifarnib in Patients With Advanced Solid Malignancies

Phase 1 Terminated

6 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT05693090 2023-03-06

Tipifarnib and Osimertinib in EGFR-mutated Non-Small Cell Lung Cancer

Phase 1 Withdrawn

Thoracic

NSCLC

NCT00093990 2016-09-14

Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)

Phase 3 Completed

457 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT00050141 2013-02-01

Study of Letrozole Plus Tipifarnib or Placebo in the Treatment of Advanced Breast Cancer

Phase 2 Completed

121 enrolled

Breast

Breast Neoplasms

NCT00005648 2011-05-19

Gemcitabine With or Without Tipifarnib (R115777) in Treating Patients With Advanced Pancreatic Cancer

Phase 3 Completed

688 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT00354146 2011-02-01

A Phase 2 Study of Farnesyl Transferase Inhibitor (R115777, Tipifarnib) in Patients With Refractory or Relapsed Acute Myeloid Leukemia.

Phase 2 Completed

252 enrolled

Other hematologic neoplasm

Recurrence, Leukemia, Myeloid, Acute

NCT00048503 2010-04-27

Study of Tipifarnib as Postconsolidation Therapy for Acute Myeloid Leukemia in Patients 60 Years and Older

Phase 2 Completed

88 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute