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NCT06540963 2026-04-28

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

Phase 2 Recruiting

Neuroblastoma

NCT03496766 2025-03-05

Tipifarnib in Advanced Squamous NSCLC With Oncogen HRAS MutAtionS

Phase 2 Terminated

9 enrolled 22 charts

Carcinoma, Non-Small-Cell Lung

NCT02535650 2022-03-08

Study of Tipifarnib in Patients With Previously-Treated, Advanced, HRAS Mutant Urothelial Carcinoma

Phase 2 Unknown

Carcinoma, Transitional Cell

NCT00050986 2020-09-22

Phase I/II Evaluation of Temozolomide and ZARNESTRA (R115777) for Recurrent and Progressive Glioblastoma Multiforme

Phase 1/2 Completed

55 enrolled 6 charts

Brain Neoplasms, Central Nervous System Diseases, Glioblastoma

NCT00077519 2020-04-15

Tipifarnib and Radiation Therapy in Treating Patients With Unresectable Locally Advanced Pancreatic Cancer

Phase 1 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT00004009 2019-11-07

R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia

Phase 1 Completed

LymphoidOther hematologic neoplasm

Blast Crisis, Leukemia, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00025480 2019-03-13

Tipifarnib Plus Radiation Therapy After Combination Chemotherapy in Treating Patients With Stage III Non-Small Cell Lung Cancer

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00847223 2018-08-23

Efficacy and Safety of the Farnesyl-transferase Inhibitor (Tipifarnib) in Mantle Cell Lymphoma

Phase 2 Terminated

Lymphoma, Recurrence, Lymphoma, Mantle-Cell

NCT00005859 2018-06-26

Tipifarnib in Treating Patients With Recurrent or Progressive Malignant Glioma

Phase 1/2 Completed

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00047216 2015-07-23

Tipifarnib in Treating Patients With Recurrent Bladder Cancer

Phase 2 Completed

Urinary Bladder Neoplasms

NCT00101153 2015-07-23

Tipifarnib, Cytarabine, and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia

Phase 1 Completed

Other hematologic neoplasm

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Basophilic, Acute, Leukemia, Eosinophilic, Acute, Leukemia, Myelomonocytic, Acute

NCT00972712 2015-03-10

Protocol of the Combination of Bortezomib and Tipifarnib for Relapsed or Refractory Multiple Myeloma

Phase 1 Completed

Multiple Myeloma

NCT00361088 2013-11-25

A Combination of Zarnestra With Velcade for Patients With Relapsed Multiple Myeloma

Phase 1/2 Terminated

Multiple Myeloma

NCT00005848 2013-07-11

R115777 in Treating Patients With Progressive, Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Phase 2 Completed

Prostatic Neoplasms

NCT00005041 2012-11-09

R115777 in Treating Patients With Relapsed Small Cell Lung Cancer

Phase 2 Completed

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00005990 2012-11-09

R115777 Plus Topotecan in Treating Patients With Advanced Solid Tumors

Phase 1 Completed

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00012350 2012-10-23

Phase II Evaluation of FTase Inhibitor (FTI)in Treatment of Advanced Multiple Myeloma

Phase 2 Completed

Multiple Myeloma, Neoplasms, Plasma Cell

NCT00040105 2012-08-01

Zarnestra and Gleevec in Chronic Phase Chronic Myelogenous Leukemia

Phase 1 Completed

MyeloidOther hematologic neoplasm

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Chronic-Phase

NCT00054470 2012-06-29

Tipifarnib Plus Trastuzumab in Treating Patients With Metastatic Breast Cancer

Phase 2 Withdrawn

Breast Neoplasms, Breast Neoplasms, Male

NCT00003707 2012-06-28

Combination Chemotherapy in Treating Patients With Advanced Cancer

Phase 1 Completed

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00209989 2011-11-24

Phase II Trial to Assess the Radiosensitizing Effect of ZARNESTRA in Patients With Glioblastoma Multiforme

Phase 2 Completed

Glioblastoma

NCT00005989 2011-08-04

R115777 in Treating Patients With Recurrent or Metastatic Non-small Cell Lung Cancer

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00025454 2010-02-08

R115777 in Treating Patients With Advanced Solid Tumors

Phase 1 Completed

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00510939 2009-08-14

HEMOS AML 0106

Phase 2 Unknown

Other hematologic neoplasm

Leukemia, Leukemia, Myeloid, Acute

NCT00210028 2006-11-14

Study Assessing Efficacy of ZARNESTRA™ Combined With Tamoxifen in Patients With Advanced or Metastatic Breast Cancer

Phase 2 Terminated

Breast Neoplasms