Announcements Trials
Browse Landscape

Phase

Phase 2 3Phase 3 1Phase 1/2 1

Status

Recruiting 12Withdrawn 5Active not recruiting 5Terminated 4Not yet recruiting 3Unknown 1Suspended 1Completed 1

Sponsor Class

INDUSTRY 9OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

Breast 4CNS 1

Conditions

Metastatic Breast Cancer With a Isolated Brain Progression 1Breast Neoplasms 1Brain Neoplasms 1Anatomic Stage II Breast Cancer AJCC v8 1Anatomic Stage IA Breast Cancer AJCC v8 1

Interventions

pembrolizumab 223Cyclophosphamide 192Radiotherapy 183Nivolumab 181Carboplatin 153Cisplatin 114Paclitaxel 112Dexamethasone 110Radiosurgery 103Magnetic Resonance Spectroscopy 97Surveys and Questionnaires 90Ipilimumab 81Doxorubicin 79Lenalidomide 76Rituximab 75durvalumab 74atezolizumab 72Radiation 72fludarabine 68Standard of Care 68Gemcitabine 68venetoclax 67Specimen Handling 65Etoposide 64Capecitabine 64Bevacizumab 62Oxaliplatin 59Docetaxel 58Biopsy 58Radiotherapy, Intensity-Modulated 56

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Active not recruiting × OTHER × tucatinib × Clear all
NCT05319873 2026-05-11

Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer

Jonsson Comprehensive Cancer Center

Phase 1/2 Active not recruiting
18 enrolled
Breast

Anatomic Stage II Breast Cancer AJCC v8

NCT05323955 2026-03-17

BRIDGET

Duke University

Phase 2 Active not recruiting
48 enrolled
CNS

Brain Neoplasms

NCT05892068 2026-02-13

A Study of Tucatinib Given Before Surgery to People With HER2+ Cancers That Have Spread to the Brain

Memorial Sloan Kettering Cancer Center

Phase 2 Active not recruiting
9 enrolled
Breast

Breast Neoplasms

NCT05041842 2025-11-17

InTTercePT

UNICANCER

Phase 2 Active not recruiting
53 enrolled
Breast

Metastatic Breast Cancer With a Isolated Brain Progression

NCT04457596 2025-10-29

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Alliance for Clinical Trials in Oncology

Phase 3 Active not recruiting
1,056 enrolled
Breast

Anatomic Stage IA Breast Cancer AJCC v8

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