Clinical Trials

36 enrolled

Tumor-Agnostic

Neoplasms

NCT00450138 2016-08-29

Open Label, Phase I ZD6474 Head and Neck Cancer Study

48 enrolled

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00681798 2016-08-29

Dose Escalation Study With Zactima and Chemotherapy in Metastatic Pancreas Carcinoma

8 enrolled

Pancreatic Neoplasms

NCT00807170 2016-08-29

Investigate the Maximum Tolerated Dose of Vandetanib and Concurrent Whole Brain Radiotherapy (WBRT) in Patients With Non-small Cell Lung Cancer (NSCLC) and Brain Metastases

Phase 1 Terminated

5 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00496275 2016-08-26

Phase I Combination With Vinorelbine or Gemcitabine Plus Cisplatin in Locally Advanced or Metastatic NSCLC

17 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00496509 2016-08-26

Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer

24 enrolled

Colorectal Neoplasms

NCT00499850 2016-08-25

Phase I FOLFOX Combination

18 enrolled

Tumor-Agnostic

Adenocarcinoma

NCT00506051 2016-08-25

ZD6474(Vandetanib) + Alimta Combo Study

21 enrolled

Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00507091 2016-08-25

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

24 enrolled

Tumor-Agnostic

Adenocarcinoma, Neoplasm Metastasis

NCT01941849 2015-12-21

VIBRaNT

Phase 1 Withdrawn

CNSEndocrineNET

Paraganglioma, Pheochromocytoma, Neuroendocrine Tumors

NCT01004419 2015-10-02

Trial of ZD6474 and Faslodex in Non-Small Cell Lung Cancer

Phase 1 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT00821080 2015-05-01

Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma

33 enrolled

Glioblastoma

NCT00996723 2015-04-06

Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)

25 enrolled

Diffuse Intrinsic Pontine Glioma

NCT00601614 2014-03-10

Vandetanib and Temozolomide in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery

Phase 1 Withdrawn

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00660725 2014-01-23

Study of GemOx and Vandetanib in Advanced Solid Malignancy

22 enrolled

Advanced Incurable Solid Malignancy

NCT00551096 2013-12-25

Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors

23 enrolled

Biliary Tract Neoplasms, Pancreatic Neoplasms

NCT00496665 2013-11-18

ZD6474 (Zactima) and Metronomic Chemotherapy in Advanced Breast Cancer

25 enrolled

Breast

Breast Neoplasms

NCT00822887 2013-06-26

IRUSZACT0073

13 enrolled

Glioma

NCT00613223 2013-02-20

Ph I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas

49 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00613054 2012-12-05

Ph I Zactima + Imatinib Mesylate & Hydroxyurea for Pts w Recurrent Malignant Glioma

27 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00472017 2012-10-15

Vandetanib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Diffuse Brainstem Glioma

35 enrolled

Central Nervous System Neoplasms

NCT00436072 2012-10-04

ZD6474, Cetuximab, and Irinotecan in Patients With Metastatic Colorectal Cancer

46 enrolled

Colorectal Neoplasms

NCT00532909 2012-07-16

Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer

13 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00734890 2012-03-16

Vandetanib and Bevacizumab in Treating Patients With Advanced Solid Tumors or Lymphoma

DermatologicLymphoidOther hematologic neoplasmThoracic

18 enrolled

Adenocarcinoma of Lung, Burkitt Lymphoma, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00533169 2011-12-15

ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma

Phase 1 Terminated

10 enrolled

Neuroblastoma

NCT00732745 2011-08-22

Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or Gastroesophageal Junction

Phase 1 Terminated

9 enrolled