Clinical Trials

142 enrolled

Phase 2 Active not recruiting

Pancreatic Neoplasms

NCT02299999 2025-01-15

SAFIR02_Breast

1,460 enrolled

Breast Neoplasms

NCT06482086 2024-12-05

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

Phase 2 Recruiting

75 enrolled

Head & Neck

Locally Advanced Thyroid Gland Carcinoma

NCT02117167 2024-01-10

SAFIR02_Lung

999 enrolled

Non-small Cell Lung Cancer Metastatic

NCT01934335 2021-11-01

Effect of Vandetanib on Cellular Markers in Invasive Breast Cancer

12 enrolled 10 charts

Breast Neoplasms

NCT01586624 2021-10-07

A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)

61 enrolled 23 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT03630120 2021-07-14

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

6 enrolled 9 charts

EndocrineHead & Neck

Thyroid cancer, medullary, Thyroid Cancer, Papillary, Thyroid Diseases, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT01183559 2021-01-22

A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery

9 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT01414426 2021-01-14

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions

Head & NeckOther neoplasm

20 enrolled 7 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Precancerous Conditions

NCT01823068 2020-12-07

Vandetanib in Advanced NSCLC With RET Rearrangement

17 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02239952 2020-10-08

HGG-TCP (High Grade Glioma - Tumor Concentrations of Protein Kinase Inhibitors)

Phase NA Unknown

15 enrolled

Glioma, Neoplasms

NCT02638428 2020-03-19

Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy

Phase 2 Unknown

90 enrolled

Other solid neoplasm

Relapsed Pediatric Solid Tumor

NCT00613626 2020-02-11

Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer

74 enrolled 19 charts

Small Cell Lung Carcinoma

NCT01191892 2019-05-16

Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer

82 enrolled

Genitourinary

Urinary Bladder Neoplasms, Ureteral Neoplasms, Urethral Neoplasms

NCT00459121 2019-03-26

Vandetanib, Carboplatin, and Paclitaxel in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer That Can Be Removed by Surgery

2 enrolled 4 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02142036 2019-03-13

MetAction

50 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT00441142 2019-03-05

Zactima

Phase 1/2 Completed

119 enrolled 15 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00745732 2018-11-14

Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)

Phase 1 Terminated

3 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00880334 2018-09-18

Randomized Study of Docetaxel +/- Vandetanib in Metastatic TCC

149 enrolled 12 charts

Genitourinary

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT00687297 2018-05-30

Study of Vandetanib Combined With Chemotherapy to Treat Advanced Non-small Cell Lung Cancer

162 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00481845 2017-02-07

Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal Hormone Receptor-Positive Breast Cancer

1 enrolled 8 charts

Breast Neoplasms

NCT02013089 2016-08-30

GITIC

Phase NA Unknown

50 enrolled

Gastrointestinal Neoplasms

NCT00290537 2016-05-19

Phase II Study of ZD6474 in Advanced NSCLC

4 enrolled 3 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00402896 2016-03-09

Malignant Pleural Effusion With ZD6474

28 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion

NCT01941849 2015-12-21

VIBRaNT

Phase 1 Withdrawn

CNSEndocrineNET

Paraganglioma, Pheochromocytoma, Neuroendocrine Tumors

NCT01004419 2015-10-02

Trial of ZD6474 and Faslodex in Non-Small Cell Lung Cancer

Phase 1 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT00821080 2015-05-01

Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma

33 enrolled

Glioblastoma

NCT00996723 2015-04-06

Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)

25 enrolled

Diffuse Intrinsic Pontine Glioma

NCT00410189 2015-03-23

BATTLE Program: ZD6474 in Previously Treated Subjects With NSCLC

54 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00683787 2015-01-08

Docetaxel With or Without Vandetanib in Treating Patients With Metastatic Stomach Cancer or Gastroesophageal Junction Cancer

8 enrolled 5 charts

Stomach Neoplasms

NCT00601614 2014-03-10

Vandetanib and Temozolomide in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery

Phase 1 Withdrawn

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00660725 2014-01-23

Study of GemOx and Vandetanib in Advanced Solid Malignancy

22 enrolled

Advanced Incurable Solid Malignancy

NCT00551096 2013-12-25

Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors

23 enrolled

Biliary Tract Neoplasms, Pancreatic Neoplasms

NCT00496665 2013-11-18

ZD6474 (Zactima) and Metronomic Chemotherapy in Advanced Breast Cancer

25 enrolled

Breast Neoplasms

NCT00811369 2013-11-18

ZAMBONEY

126 enrolled

Breast Neoplasms

NCT00459043 2013-07-03

Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck

30 enrolled 10 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT00822887 2013-06-26

IRUSZACT0073

13 enrolled

Glioma

NCT00613223 2013-02-20

Ph I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas

49 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00757692 2013-02-20

Efficacy and Safety Study of Vandetanib (ZD 6474) in Combination With Bicalutamide Versus Bicalutamide Alone in Patients With Chemotherapy Naive Hormone Refractory Prostate Cancer.

74 enrolled

Genitourinary

Prostatic Neoplasms

NCT00613054 2012-12-05

Ph I Zactima + Imatinib Mesylate & Hydroxyurea for Pts w Recurrent Malignant Glioma

27 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00472017 2012-10-15

Vandetanib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Diffuse Brainstem Glioma

35 enrolled

Central Nervous System Neoplasms

NCT00436072 2012-10-04

ZD6474, Cetuximab, and Irinotecan in Patients With Metastatic Colorectal Cancer

46 enrolled

Colorectal Neoplasms

NCT00532909 2012-07-16

Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer

13 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00533169 2011-12-15

ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma

Phase 1 Terminated

10 enrolled

Neuroblastoma

NCT00732745 2011-08-22

Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or Gastroesophageal Junction

Phase 1 Terminated

9 enrolled