Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases
Phase 2 Completed
344 enrolled 11 charts
Pilot Study of Veliparib (ABT-888) and Lapatinib (Tykerb) in Patients With Metastatic, Triple Negative Breast Cancer
Phase NA Completed
20 enrolled 10 charts
Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer
Phase 2 Completed
363 enrolled 16 charts
Veliparib and Temozolomide in Treating Patients With Acute Leukemia
Phase 1 Completed
66 enrolled
ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer
Phase 1/2 Completed
64 enrolled 20 charts
Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer
Phase 2 Completed
77 enrolled 17 charts
Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer
Phase 2 Completed
9 enrolled 10 charts
Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery
Phase 1 Completed
73 enrolled
Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders
Phase 1 Completed
12 enrolled
ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer
Phase 2 Completed
63 enrolled 11 charts
A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer
Phase 3 Completed
513 enrolled 16 charts
Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors
Phase 1 Completed
18 enrolled
Phase I/Ib Study of Nivolumab & Veliparib in Patients With Advanced Solid Tumors & Lymphoma
Phase 1 Completed
15 enrolled 18 charts
Pre-Operative Radiation and Veliparib for Breast Cancer
Phase 1 Completed
19 enrolled
MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations
Phase 2 Completed
208 enrolled 27 charts
Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer
Phase 1/2 Completed
24 enrolled 12 charts
Arterial Hypertension Related to PARP Inhibitors (ArteRIB)
Completed
2,336 enrolled
Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer
Phase 1/2 Completed
156 enrolled 13 charts
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors
Phase 1 Completed
53 enrolled 20 charts
Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide (TMZ) or In Combination With Carboplatin and Paclitaxel Versus Placebo in Participants With Breast Cancer Gene (BRCA)1 and BRCA2 Mutation and Metastatic Breast Cancer
Phase 2 Completed
294 enrolled 19 charts
Carboplatin, Paclitaxel, Bevacizumab, and Veliparib in Treating Patients With Newly Diagnosed Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
Phase 1 Completed
431 enrolled
Pancytopenia Related to PARP Inhibitors (PancytoRIB)
Completed
200 enrolled
A Study of ABT-888 in Combination With Carboplatin and Gemcitabine in Subjects With Advanced Solid Tumors
Phase 1 Completed
79 enrolled
Evaluating the Safety and Tolerability of the Poly-ADP Ribose (PARP) Inhibitor With FOLFIRI in Subjects With Solid Tumor
Phase 1 Completed
60 enrolled
Study of Gemcitabine, Carboplatin and VELIPARIB (ABT-888) in Refractory Testicular Germ Cell Cancer
Phase 2 Completed
15 enrolled
Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) and Who Are Current or Former Smokers
Phase 3 Completed
595 enrolled 22 charts
A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer
Phase 3 Completed
634 enrolled
Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
Phase 3 Completed
970 enrolled
Abiraterone Acetate and Prednisone With or Without Veliparib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Phase 2 Completed
159 enrolled 12 charts
VelGemRad
Phase 1 Completed
34 enrolled
Veliparib and Floxuridine in Treating Patients With Metastatic Epithelial Ovarian, Primary Peritoneal Cavity, or Fallopian Tube Cancer
Phase 1 Completed
29 enrolled
Dose Escalation and Double-blind Study of Veliparib in Combination With Carboplatin and Etoposide in Treatment-naive Extensive Stage Disease Small Cell Lung Cancer
Phase 1/2 Completed
221 enrolled 37 charts
ABT-888 Plus Metronomic Cyclophosphamide to Treat Cancer
Phase 1 Completed
35 enrolled
Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors
Phase 1/2 Completed
43 enrolled 18 charts
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors
Phase 1 Completed
9 enrolled
Study of Veliparib in Combination With Nivolumab and Platinum Doublet Chemotherapy in Participants With Metastatic or Advanced Non-Small Cell Lung Cancer (NSCLC)
Phase 1 Completed
25 enrolled
Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas
Phase 1/2 Completed
66 enrolled 24 charts
Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer
Phase 2 Completed
27 enrolled 11 charts
Veliparib in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Phase 2 Completed
52 enrolled 12 charts
Pegylated Liposomal Doxorubicin Hydrochloride, Carboplatin, Veliparib, and Bevacizumab in Treating Patients With Recurrent Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
Phase 1 Completed
41 enrolled
Paclitaxel, Cisplatin, and Veliparib in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
Phase 1 Completed
37 enrolled
A Study of ABT-888 in Combination With Temozolomide for Colorectal Cancer
Phase 2 Completed
75 enrolled 10 charts
Study Comparing Veliparib Plus FOLFIRI Versus Placebo Plus FOLFIRI With or Without Bevacizumab in Previously Untreated Metastatic Colorectal Cancer
Phase 2 Completed
130 enrolled 12 charts
Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy
Phase 1 Completed
98 enrolled
ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Phase 1 Completed
24 enrolled
A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanoma
Phase 2 Completed
346 enrolled 15 charts
A Trial of ABT-888 in Combination With Temozolomide Versus Pegylated Liposomal Doxorubicin Alone in Ovarian Cancer
Phase 2 Completed
168 enrolled
Comparison of Veliparib and Whole Brain Radiation Therapy (WBRT) Versus Placebo and WBRT in Adults With Brain Metastases From Non-Small Cell Lung Cancer
Phase 2 Completed
307 enrolled 15 charts
A Phase 1 Study of Single Agent Veliparib in Japanese Subjects With Advanced Solid Tumors
Phase 1 Completed
16 enrolled
Veliparib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer or Metastatic Breast Cancer
Phase 1 Completed
45 enrolled