Clinical Trials Browser

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Phase 1 Terminated

144 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT05045950 2025-04-25

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Phase 2 Recruiting

53 enrolled

CNS

Brain Neoplasms

NCT02360215 2025-04-23

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

Phase 3 Completed

518 enrolled 40 charts

CNS

Brain Neoplasms, Cognitive Dysfunction

NCT04217694 2024-11-21

Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

Phase EARLY_PHASE1 Completed

18 enrolled

CNS

Central Nervous System Neoplasms

NCT05664464 2024-05-10

GLUGLIO

Phase 1/2 Recruiting

120 enrolled

CNS

Epilepsy, Glioblastoma

NCT03194906 2023-07-13

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

Phase 2 Completed

34 enrolled

CNS

Brain Neoplasms, Craniopharyngioma, Ependymoma, Neoplasms, Germ Cell and Embryonal

NCT04801342 2021-03-17

Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases

Phase 2 Unknown

72 enrolled

CNS

Brain Neoplasms

NCT00566852 2017-08-21

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Phase 3 Completed

554 enrolled 12 charts

CNS

Brain Neoplasms, Neoplasm Metastasis, Neurotoxicity Syndromes

NCT01260467 2015-12-10

Memantine for Recurrent Glioblastoma

Phase 2 Terminated

4 enrolled 3 charts

CNS

Glioblastoma, Recurrence

Clinical Trials

NTS-WBRT in Brain Metastases

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

MemoryRT

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery