Clinical Trials Browser

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Phase 1 Terminated

144 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT05045950 2025-04-25

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Phase 2 Recruiting

53 enrolled

CNS

Brain Neoplasms

NCT02360215 2025-04-23

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

Phase 3 Completed

518 enrolled 40 charts

CNS

Brain Neoplasms, Cognitive Dysfunction

NCT04217694 2024-11-21

Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

Phase EARLY_PHASE1 Completed

18 enrolled

CNS

Central Nervous System Neoplasms

NCT06679387 2024-11-07

"The Effect of Memantine on the Prevention and Amelioration of Paclitaxel-induced Toxicity in Breast Cancer Patients"

Phase 2 Recruiting

80 enrolled

Breast

Breast Cancer Early Stage Breast Cancer (Stage 1-3)

NCT05664464 2024-05-10

GLUGLIO

Phase 1/2 Recruiting

120 enrolled

CNS

Epilepsy, Glioblastoma

NCT03194906 2023-07-13

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

Phase 2 Completed

34 enrolled

CNS

Brain Neoplasms, Craniopharyngioma, Ependymoma, Neoplasms, Germ Cell and Embryonal

NCT05834231 2023-04-28

Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Phase 1/2 Unknown

60 enrolled

Tumor-Agnostic

Neoplasms

NCT04033419 2023-04-20

Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer

Phase 2 Completed

55 enrolled 21 charts

Cognitive Dysfunction

NCT01535040 2021-09-28

Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

Phase 2 Completed

130 enrolled 12 charts

BreastGastrointestinalGenitourinaryThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Tobacco Use Disorder, Colorectal Neoplasms

NCT04801342 2021-03-17

Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases

Phase 2 Unknown

72 enrolled

CNS

Brain Neoplasms

NCT04737967 2021-02-04

The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy

Phase 2/3 Unknown

60 enrolled

Cancer Pain

NCT00566852 2017-08-21

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Phase 3 Completed

554 enrolled 12 charts

CNS

Brain Neoplasms, Neoplasm Metastasis, Neurotoxicity Syndromes

NCT01260467 2015-12-10

Memantine for Recurrent Glioblastoma

Phase 2 Terminated

4 enrolled 3 charts

CNS

Glioblastoma, Recurrence

Clinical Trials

NTS-WBRT in Brain Metastases

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Neuroprotection of Memantine and Rosuvastatin

MemoryRT

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Memantine Hydrochloride in Prostate Cancer Patients

(HCC)

A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

"The Effect of Memantine on the Prevention and Amelioration of Paclitaxel-induced Toxicity in Breast Cancer Patients"

GLUGLIO

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer

Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases

The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Memantine for Recurrent Glioblastoma