Clinical Trials

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Adrenocortical Carcinoma, Pituitary ACTH Hypersecretion

NCT06607692 2026-04-14

LUPARPED

Phase 1/2 Recruiting

25 enrolled

CNSEndocrineNETSarcoma

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroblastoma, Paraganglioma, Pheochromocytoma, Recurrence, Osteosarcoma, Sarcoma, Synovial, Esthesioneuroblastoma, Olfactory, Neuroendocrine Tumors

NCT06006013 2026-02-18

Cabozantinib in Combination With Pembrolizumab for the Treatment of Patients With Locally Advanced, Metastatic, or Unresectable Adrenal Cortical Cancer

Phase 2 Recruiting

21 enrolled

Phase 2 Active not recruiting

Adrenal Cortex Neoplasms, Adrenocortical Carcinoma

NCT02721732 2026-01-29

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

157 enrolled 26 charts

CNSEndocrineGenitourinary

Adrenal Cortex Neoplasms, Carcinoma, Renal Cell, Neoplasm Metastasis, Neoplasms, Unknown Primary, Paraganglioma, Penile Neoplasms, Pheochromocytoma, Carcinoma, Small Cell, Vascular Neoplasms

NCT07072143 2025-07-18

PARTNER

Recruiting

6,250 enrolled

CNSDermatologicGastrointestinalHead & NeckOther solid neoplasmSarcomaThoracic

Pleuropulmonary blastoma, Nasopharyngeal Carcinoma, Adrenal Cortex Neoplasms, Melanoma, Mesothelioma, Pancreatic Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Esthesioneuroblastoma, Olfactory, Gastrointestinal Stromal Tumors

NCT06279442 2025-02-12

Adrenal Project: Clinical and Epidemiological Characterization of Adrenocortical Carcinoma in a Brazilian Cohort

Recruiting

150 enrolled

Adrenal Cortex Neoplasms, Carcinoma

NCT03370718 2024-12-10

Cabozantinib in Treating Patients With Locally Advanced or Metastatic Unresectable Adrenocortical Carcinoma

18 enrolled 5 charts

Adrenal Cortex Neoplasms

NCT03612232 2024-08-19

CaboACC

Phase 2 Unknown

37 enrolled

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Adrenocortical Carcinoma

NCT04373265 2024-02-23

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

Phase 1 Completed

15 enrolled

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Adrenal Gland Diseases, Adrenocortical Hyperfunction, Cushing Syndrome, Diabetes Mellitus, Type 2, Endocrine System Diseases, Hyperglycemia, Hypertension, Pathologic Processes, Glucose Intolerance, Adrenocortical Carcinoma

NCT06050057 2023-09-22

Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy

Recruiting

100 enrolled

Adrenal Cortex Diseases, Adrenal Cortex Neoplasms, Adrenal Gland Diseases, Adrenal Gland Neoplasms, Adrenal Hyperplasia, Congenital, Cushing Syndrome, Pheochromocytoma, Adrenocortical Adenoma, Adrenocortical Carcinoma

NCT04447014 2023-01-17

Natural History Study of Children and Adults With Adrenocortical Cancer (ACC)

Terminated

15 enrolled

Adrenal Cortex Neoplasms, Adrenocortical Carcinoma

NCT04890444 2022-02-14

CASE

2,000 enrolled

Adrenal incidentaloma, ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Adrenal Insufficiency, Adrenal Hyperplasia, Congenital, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma

NCT04666220 2021-02-12

VETC, Prognostic and Predictive Value in Renal Cell Carcinoma and Adrenal Carcinoma

180 enrolled

Genitourinary

Adrenal Cortex Neoplasms, Carcinoma, Renal Cell

NCT02468193 2020-05-06

Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome

9 enrolled 22 charts

Acth-Independent Macronodular Adrenal Hyperplasia, ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome

NCT02804750 2019-10-15

Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

35 enrolled 13 charts

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Adrenocortical Carcinoma, Pituitary ACTH Hypersecretion

NCT02720484 2019-05-01

Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer

Phase 2 Terminated

10 enrolled 11 charts

Adrenal Cortex Neoplasms

NCT02747355 2019-01-18

Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors

70 enrolled

Adrenal Cortex Diseases, Adrenal Cortex Neoplasms

NCT03517332 2018-11-20

Circulating Tumor DNA Exposure in Peripheral Blood

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

10,000 enrolled

Adrenal Cortex Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT00215202 2018-05-17

Phase II Trial of ZD1839 (Iressa) in Patients With Nonresectable Adrenocortical Carcinoma (ACC)

16 enrolled

DermatologicEndocrineGastrointestinalNET

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms

NCT02831179 2017-09-28

Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor

Phase 1 Withdrawn

Non functioning pancreatic endocrine tumor, Adrenal Cortex Neoplasms, Carcinoid Tumor, Vipoma, Glucagonoma, Insulinoma, Pheochromocytoma, Somatostatinoma, Zollinger-Ellison Syndrome, Carcinoma, Merkel Cell, Carcinoma, Medullary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Multiple Endocrine Neoplasia Type 2b

NCT00796783 2014-06-20

A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia

Terminated

2 enrolled

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT00936741 2014-04-02

An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome

Phase 3 Completed

30 enrolled 8 charts

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT00569582 2013-08-22

SEISMIC

Phase 3 Completed

50 enrolled 8 charts

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT01255137 2013-06-27

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer

13 enrolled 9 charts

Adrenal Cortex Neoplasms

NCT00071058 2012-09-18

Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer