Clinical Trials

Phase 1/2 Active not recruiting

114 enrolled

GenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Angiomyolipoma, Vascular Neoplasms

NCT05395741 2026-03-25

Regbone

30 enrolled

DermatologicGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

Bone Neoplasms, Sarcoma, Ewing, Osteosarcoma

NCT03420963 2026-03-20

Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

Phase 1 Terminated

12 enrolled

Mesothelioma, Malignant, Bone Neoplasms, Endocrine Gland Neoplasms, Melanoma, Mouth Neoplasms, Pharyngeal Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Urologic Neoplasms

NCT03965234 2026-03-17

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

Phase 1/2 Recruiting

99 enrolled

GastrointestinalSarcoma

Bone Neoplasms, Sarcoma, Colorectal Neoplasms

NCT05051059 2026-03-16

QOLSarcoma

Phase NA Recruiting

60 enrolled

Bone Neoplasms, Sarcoma

NCT05033288 2026-03-13

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

72 enrolled

Bone Neoplasms, Chondrosarcoma, Chordoma

NCT07471022 2026-03-13

PHM-HA

53 enrolled

Bone Neoplasms

NCT02893397 2026-03-05

Supervised Exercise in Improving Physical Fitness Before Surgery in Patients With Resectable Bone Cancer

45 enrolled

Bone Neoplasms

NCT04307914 2026-03-05

FURTHER

216 enrolled

Bone Neoplasms, Neoplasm Metastasis, Neoplasms, Pain

NCT05038124 2026-03-05

A Study of Stereotactic Body Radiotherapy (SBRT) and Surgical Stabilization for People With Cancer That Has Spread to the Bone

39 enrolled

Bone Neoplasms, Neoplasm Metastasis

NCT03442465 2026-03-04

Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas

300 enrolled

Bone Neoplasms, Chondrosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT07193550 2026-02-27

A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

70 enrolled

Bone Neoplasms

NCT04055220 2026-02-17

REGOSTA

Phase NA Recruiting

168 enrolled

Pathologic Complete Response, Bone Neoplasms, Chondrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Patient Compliance, Sarcoma, Ewing, Osteosarcoma, Histiocytoma, Malignant Fibrous

NCT04698785 2026-02-17

REGOMAIN

36 enrolled

Phase NA Not yet recruiting

Bone Neoplasms, Osteosarcoma

NCT07325578 2026-02-12

EPIOS

60 enrolled

Bone Neoplasms, Osteoporosis

NCT02677961 2026-02-11

An Electronic Health Record (EHR)-Based Comprehensive Bone and Soft Tissue Tumor Registry

1,500 enrolled

Bone Neoplasms, Sarcoma, Neoplasms, Connective and Soft Tissue

NCT05726383 2026-02-10

Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma

32 enrolled

Bone Neoplasms, Neoplasm Metastasis, Sarcoma

NCT06409013 2026-02-06

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

50 enrolled

Bone Neoplasms, Sarcoma

NCT05746429 2026-02-04

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer

68 enrolled 20 charts

Bone Neoplasms, Neoplasms

NCT05779670 2026-02-03

ADER

50 enrolled

Bone Neoplasms, Chondrosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT06376539 2026-02-03

FISIO-ONCO

100 enrolled

Bone Neoplasms

NCT07379008 2026-01-30

Safety and Efficacy of Non-Setting Paste in Bone Defect Reconstruction

29 enrolled

Bone Cysts, Bone Diseases, Bone Neoplasms, Enchondromatosis

NCT05419518 2026-01-23

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

124 enrolled

Bone Neoplasms, Neoplasm Metastasis

NCT07323017 2026-01-14

Electrochemotherapy in Musculoskeletal Tumors

Active not recruiting

60 enrolled

Bone Neoplasms

NCT07197645 2026-01-13

SOLACE

33 enrolled

Bone Neoplasms

NCT07337018 2026-01-13

RERIO

Not yet recruiting

100 enrolled

Phase 1 Active not recruiting

Bone Neoplasms

NCT04616248 2026-01-07

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

14 enrolled

BreastDermatologicSarcoma

Bone Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Melanoma, Sarcoma, Osteosarcoma, Carcinoma, Merkel Cell

NCT07314424 2026-01-02

The Effect of Preoperative Intravenous Ferric Derisomaltose and EPO and Tranexamic Acid in Patients With Preoperative Anemia or Iron Deficiency in Bone Tumor

Phase 4 Not yet recruiting

160 enrolled

Classical hematologySarcoma

Anemia, Bone Neoplasms

NCT06562673 2025-12-29

IACE-OS

Phase 1/2 Completed

10 enrolled

Bone Neoplasms, Osteosarcoma

NCT03963531 2025-12-10

METABONE

545 enrolled 7 charts

Bone Neoplasms

NCT03225872 2025-12-02

BOOST

362 enrolled

Bone Neoplasms, Osteosarcoma

NCT07259304 2025-12-02

Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors

CNSGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

250 enrolled

Bone Neoplasms, Brain Neoplasms, Uterine Cervical Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Ovarian Neoplasms, Testicular Neoplasms, Colorectal Neoplasms, Central Nervous System Neoplasms, Carcinoma, Medullary

NCT02811523 2025-11-26

In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma

17 enrolled

Phase 2 Active not recruiting

Bone Neoplasms, Sarcoma

NCT03449108 2025-11-21

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

30 enrolled

BreastEndocrineGynecologicHead & NeckSarcoma

Bone Neoplasms, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Giant Cell Tumor of Bone, Histiocytoma, Malignant Fibrous, Triple Negative Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05312411 2025-11-20

A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma

Phase 1 Active not recruiting

21 enrolled

Bone Neoplasms, Osteosarcoma

NCT03093909 2025-11-10

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

DermatologicGenitourinarySarcoma

44 enrolled

Bone Neoplasms, Melanoma, Osteosarcoma, Urologic Neoplasms

NCT06720142 2025-11-03

Mg OSTEOCRETE Post-Treatment Outcomes

10 enrolled

Bone Neoplasms, Wounds and Injuries

NCT06171945 2025-10-27

AYAConnect

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOtherOther hematologic neoplasmSarcoma

63 enrolled

Psychological Well-Being, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Motor Activity, Mouth Neoplasms, Neoplasms, Obesity, Pancreatic Neoplasms, Pharyngeal Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Weight Loss, Endometrial Neoplasms, Overweight

NCT05621668 2025-10-20

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

40 enrolled

Bone Neoplasms, Sarcoma

NCT03160274 2025-10-15

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

CNSEndocrineGenitourinaryHead & NeckSarcoma

2,000 enrolled

Bone Neoplasms, Kidney Neoplasms, Neoplastic Syndromes, Hereditary, Paraganglioma, Pheochromocytoma, Thyroid Neoplasms

NCT07215611 2025-10-10

Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas

100 enrolled

Phase 4 Enrolling by invitation

Financial Stress, Bone Neoplasms

NCT03244020 2025-10-03

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

2,868 enrolled

Classical hematologySarcoma

Bone Neoplasms, Hematoma, Sarcoma, Venous Thromboembolism

NCT06376682 2025-09-22

EPIBONE

34 enrolled 11 charts

Bone Neoplasms, Fractures, Bone

NCT04515459 2025-09-15

EPOP-SARCOMA

53 enrolled

Phase 2 Active not recruiting

Bone Neoplasms, Sarcoma

NCT02880319 2025-09-09

Evaluating Stereotactic Body Radiation Therapy for Oligometastatic Disease of the Bone

150 enrolled 12 charts

Bone Neoplasms

NCT06335251 2025-08-28

Radiotherapy Treatments for Neoplasms of the Limbs

3,000 enrolled

Bone Neoplasms

NCT06582849 2025-08-26

EARN