Clinical Trials

Phase 1/2 Active not recruiting

LymphoidSarcoma

Bone Neoplasms, Hodgkin Disease, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05395741 2026-03-25

Regbone

30 enrolled

DermatologicGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

Bone Neoplasms, Sarcoma, Ewing, Osteosarcoma

NCT03420963 2026-03-20

Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

Phase 1 Terminated

12 enrolled

Mesothelioma, Malignant, Bone Neoplasms, Endocrine Gland Neoplasms, Melanoma, Mouth Neoplasms, Pharyngeal Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Urologic Neoplasms

NCT03965234 2026-03-17

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

Phase 1/2 Recruiting

99 enrolled

GastrointestinalSarcoma

Bone Neoplasms, Sarcoma, Colorectal Neoplasms

NCT05051059 2026-03-16

QOLSarcoma

Phase NA Recruiting

60 enrolled

Bone Neoplasms, Sarcoma

NCT05033288 2026-03-13

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

72 enrolled

Bone Neoplasms, Chondrosarcoma, Chordoma

NCT07471022 2026-03-13

PHM-HA

53 enrolled

Phase NA Active not recruiting

Bone Neoplasms

NCT02893397 2026-03-05

Supervised Exercise in Improving Physical Fitness Before Surgery in Patients With Resectable Bone Cancer

45 enrolled

Phase NA Active not recruiting

Bone Neoplasms

NCT04307914 2026-03-05

FURTHER

216 enrolled

Phase NA Active not recruiting

Bone Neoplasms, Neoplasm Metastasis, Neoplasms, Pain

NCT05038124 2026-03-05

A Study of Stereotactic Body Radiotherapy (SBRT) and Surgical Stabilization for People With Cancer That Has Spread to the Bone

39 enrolled

Bone Neoplasms, Neoplasm Metastasis

NCT07193550 2026-02-27

A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

70 enrolled

Bone Neoplasms

NCT04055220 2026-02-17

REGOSTA

Phase NA Recruiting

168 enrolled

Pathologic Complete Response, Bone Neoplasms, Chondrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Patient Compliance, Sarcoma, Ewing, Osteosarcoma, Histiocytoma, Malignant Fibrous

NCT04698785 2026-02-17

REGOMAIN

36 enrolled

Bone Neoplasms, Osteosarcoma

NCT02677961 2026-02-11

An Electronic Health Record (EHR)-Based Comprehensive Bone and Soft Tissue Tumor Registry

1,500 enrolled

Bone Neoplasms, Sarcoma, Neoplasms, Connective and Soft Tissue

NCT05726383 2026-02-10

Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma

32 enrolled

Bone Neoplasms, Neoplasm Metastasis, Sarcoma

NCT06409013 2026-02-06

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

50 enrolled

Bone Neoplasms, Sarcoma

NCT05746429 2026-02-04

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer

68 enrolled 20 charts

Bone Neoplasms, Neoplasms

NCT05779670 2026-02-03

ADER

50 enrolled

Bone Neoplasms, Chondrosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT06376539 2026-02-03

FISIO-ONCO

Bone Neoplasms

NCT05419518 2026-01-23

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

124 enrolled

Bone Neoplasms, Neoplasm Metastasis

NCT07323017 2026-01-14

Electrochemotherapy in Musculoskeletal Tumors

Active not recruiting

60 enrolled

Bone Neoplasms

NCT07337018 2026-01-13

RERIO

Not yet recruiting

Phase 1 Active not recruiting

Bone Neoplasms

NCT04616248 2026-01-07

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

14 enrolled

BreastDermatologicSarcoma

Bone Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Melanoma, Sarcoma, Osteosarcoma, Carcinoma, Merkel Cell

NCT07314424 2026-01-02

The Effect of Preoperative Intravenous Ferric Derisomaltose and EPO and Tranexamic Acid in Patients With Preoperative Anemia or Iron Deficiency in Bone Tumor

Phase 4 Not yet recruiting

160 enrolled

Classical hematologySarcoma

Anemia, Bone Neoplasms

NCT06562673 2025-12-29

IACE-OS

Phase 1/2 Completed

10 enrolled

Bone Neoplasms, Osteosarcoma

NCT03963531 2025-12-10

METABONE

545 enrolled 7 charts

Bone Neoplasms

NCT03225872 2025-12-02

BOOST

362 enrolled

Bone Neoplasms, Osteosarcoma

NCT07259304 2025-12-02

Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors

CNSGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

250 enrolled

Bone Neoplasms, Brain Neoplasms, Uterine Cervical Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Ovarian Neoplasms, Testicular Neoplasms, Colorectal Neoplasms, Central Nervous System Neoplasms, Carcinoma, Medullary

NCT02811523 2025-11-26

In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma

Phase 1 Recruiting

17 enrolled

Phase 2 Active not recruiting

Bone Neoplasms, Sarcoma

NCT03449108 2025-11-21

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

30 enrolled

BreastEndocrineGynecologicHead & NeckSarcoma

Bone Neoplasms, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Giant Cell Tumor of Bone, Histiocytoma, Malignant Fibrous, Triple Negative Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05312411 2025-11-20

A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma

Phase 1 Active not recruiting

21 enrolled

DermatologicGenitourinarySarcoma

Bone Neoplasms, Osteosarcoma

NCT03093909 2025-11-10

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Phase 1 Recruiting

44 enrolled

Bone Neoplasms, Melanoma, Osteosarcoma, Urologic Neoplasms

NCT06720142 2025-11-03

Mg OSTEOCRETE Post-Treatment Outcomes

10 enrolled

Bone Neoplasms, Wounds and Injuries

NCT06171945 2025-10-27

AYAConnect

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOtherOther hematologic neoplasmSarcoma

63 enrolled

Psychological Well-Being, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Motor Activity, Mouth Neoplasms, Neoplasms, Obesity, Pancreatic Neoplasms, Pharyngeal Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Weight Loss, Endometrial Neoplasms, Overweight

NCT05621668 2025-10-20

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

Phase 1 Recruiting

40 enrolled

Bone Neoplasms, Sarcoma

NCT03160274 2025-10-15

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

CNSEndocrineGenitourinaryHead & NeckSarcoma

2,000 enrolled

Bone Neoplasms, Kidney Neoplasms, Neoplastic Syndromes, Hereditary, Paraganglioma, Pheochromocytoma, Thyroid Neoplasms

NCT07215611 2025-10-10

Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas

Phase 4 Enrolling by invitation

Financial Stress, Bone Neoplasms

NCT03244020 2025-10-03

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

2,868 enrolled

Classical hematologySarcoma

Bone Neoplasms, Hematoma, Sarcoma, Venous Thromboembolism

NCT04515459 2025-09-15

EPOP-SARCOMA

53 enrolled

Phase 2 Active not recruiting

Bone Neoplasms, Sarcoma

NCT02880319 2025-09-09

Evaluating Stereotactic Body Radiation Therapy for Oligometastatic Disease of the Bone

150 enrolled 12 charts

Bone Neoplasms

NCT06335251 2025-08-28

Radiotherapy Treatments for Neoplasms of the Limbs

3,000 enrolled

Bone Neoplasms

NCT06582849 2025-08-26

EARN

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcomaThoracic

33 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT07113301 2025-08-08

INSPECTOR

Active not recruiting

42 enrolled

Bone Neoplasms

NCT06522165 2025-08-01

Pediatric Oncological Orthopaedic Reconstruction

Active not recruiting

400 enrolled

Phase NA Not yet recruiting

Bone Neoplasms

NCT07056946 2025-07-15

Supra Inguinal Fascia Iliaca Block Versus Ultrasound-guided Caudal Analgesia for Pediatrics Undergoing Anterior and Lateral Thigh Surgeries: A Randomized Controlled Trial

70 enrolled

Bone Neoplasms

NCT00592293 2025-07-03

Proton Radiation for the Treatment of Pediatric Bone and Non-Rhabdomyosarcoma Soft Tissue Sarcomas

70 enrolled 9 charts

Phase 3 Active not recruiting

Bone Neoplasms, Sarcoma

NCT05115331 2025-05-31

1-2 PUNCH

168 enrolled

Bone Diseases, Bone Neoplasms

NCT06737172 2025-05-28

FOCUS

Enrolling by invitation

18 enrolled

Phase NA Enrolling by invitation

Bone Neoplasms, Sarcoma

NCT06743958 2025-05-28

Prehab4Kids

16 enrolled